Arts and Entertainment Jared Leto in 'Dallas Buyers Club'

When will TV and film start opening the door to transgender actors, asks Paris Lees

Diet has long informed how society perceives weight and body image

In the last 50 years our diet has been transformed. From boiled beef and carrots to a Big Mac and fries, we have moved from a world of shortages and post-war rationing to one of overabundance.

The moai, giant stone statues that line the Easter Island coast

This week's big questions: Can ancient tribes teach us anything? Are we doomed, like Easter Islanders, to extinction?

This week's questions are answered by Jared Diamond, an American scientist and the author of the bestselling ‘Guns, Germs, and Steel

Spencer Cox: Activist who helped bring an anti-Aids drug on to the market

Spencer Cox, who died in New York of Aids-related causes on 18 December aged 44, was an Aids activist who helped form an organisation to boost treatment research and recently appeared in a documentary about an Aids coalition.

Sir Ian McKellen was memerising in his reading of The Prelude by Wordsworth

Sir Ian McKellen speaks of prostate cancer shock

Sir Ian McKellen has told how he feared the worst when he was diagnosed with prostate cancer.

Anne Hathaway has tried extreme – and extremely unpleasant – eating regimes to lose weight for a part

Hollywood roles to diet for

If you find it hard to lose weight, be glad you're not an actor. Playing an emaciated waif can mean mad, bad and dangerous eating plans, says Gillian Orr

Books of the Year 2012: Celebrity

From art to sport, poetry to nature, travel to food, history to music: our writers select the best of the year’s books in a comprehensive guide to the highlights in every shade of the literary spectrum – except grey

David Cecil in a Kampala court cell after his arrest earlier this month

Together the voices of reason and care can bring sexual equality to an ever more draconian Uganda

Our writer, who saw an unlikely champion of gay rights fight for his beliefs in an African court, says that there are grounds for optimism in the battle for equality there

World AIDS Day: Health problems do not discriminate based on where people live

It's not just low income countries that have a problem.

Editorial: Aids treatment is a success story, but more must be done

In 2000, a year's course of anti-retroviral drugs cost $10,000 and projections caused consternation even in Western countries coping with a few thousand cases of HIV. The idea that treatment might be rolled out to millions in the developing world seemed a pipe dream.

Elderly women in Kasarika, a village with one of the highest rates of HIV in Malawi

World Aids Day: The curse of being one of the witches of Malawi

An Aids awareness scheme is teaching villagers HIV is an illness, and not caused by witchcraft. By Hazel Southam in Kasarika

A torch light rally is held in Kolkata yesterday ahead of World Aids Day

World Aids Day: ‘Turning the tide will fail if funding is not increased’

Three decades on from the start of the Aids pandemic, the main global agencies are uncertain whether to be cheerful or gloomy about prospects for the worst disease of modern times .

Patient co-ordinator Chris is one of the longest living survivors of HIV in Britain

World Aids Day: Suddenly I had a future, the relief was immense

Patient co-ordinator Chris is one of the longest living survivors of HIV in Britain. He speaks to Patrick Strudwick

World Aids Day: I met Enoch. Three years ago he couldn't stand up. Now his life is transformed. The cost? 23p a day

I choose not to listen to the cynics, whose philosophical opposition to aid bewilders me

World AIDS Day: A race against time as HIV treatment is cut

Anti-retrovirals are vital in improving and saving the lives of children with HIV.

The Vivisector: Group show curated by Todd Levin, Sprüth Magers, London

A naked doll with long synthetic hair greets the visitor to this inspired exhibition, which explores "the idea of opening up and exposing a living body".

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Independent Travel
Pompeii, Capri & the Bay of Naples
Seven Cities of Italy
Burgundy, the River Rhone & Provence
Prague, Budapest and Vienna
Lake Garda
3.	Provence 6 nights B&B by train from £599pp
Prices correct as of 20 February 2015
Homeless Veterans campaign: Donations hit record-breaking £1m target after £300,000 gift from Lloyds Bank

Homeless Veterans campaign

Donations hit record-breaking £1m target after huge gift from Lloyds Bank
Flight MH370 a year on: Lost without a trace – but the search goes on

Lost without a trace

But, a year on, the search continues for Flight MH370
Germany's spymasters left red-faced after thieves break into brand new secret service HQ and steal taps

Germany's spy HQ springs a leak

Thieves break into new €1.5bn complex... to steal taps
International Women's Day 2015: Celebrating the whirlwind wit of Simone de Beauvoir

Whirlwind wit of Simone de Beauvoir

Simone de Beauvoir's seminal feminist polemic, 'The Second Sex', has been published in short-form for International Women's Day
Mark Zuckerberg’s hiring policy might suit him – but it wouldn’t work for me

Mark Zuckerberg’s hiring policy might suit him – but it wouldn’t work for me

Why would I want to employ someone I’d be happy to have as my boss, asks Simon Kelner
Confessions of a planespotter: With three Britons under arrest in the UAE, the perils have never been more apparent

Confessions of a planespotter

With three Britons under arrest in the UAE, the perils have never been more apparent. Sam Masters explains the appeal
Russia's gulag museum 'makes no mention' of Stalin's atrocities

Russia's gulag museum

Ministry of Culture-run site 'makes no mention' of Stalin's atrocities
The big fresh food con: Alarming truth behind the chocolate muffin that won't decay

The big fresh food con

Joanna Blythman reveals the alarming truth behind the chocolate muffin that won't decay
Virginia Ironside was my landlady: What is it like to live with an agony aunt on call 24/7?

Virginia Ironside was my landlady

Tim Willis reveals what it's like to live with an agony aunt on call 24/7
Paris Fashion Week 2015: The wit and wisdom of Manish Arora's exercise in high camp

Paris Fashion Week 2015

The wit and wisdom of Manish Arora's exercise in high camp
8 best workout DVDs

8 best workout DVDs

If your 'New Year new you' regime hasn’t lasted beyond February, why not try working out from home?
Paul Scholes column: I don't believe Jonny Evans was spitting at Papiss Cissé. It was a reflex. But what the Newcastle striker did next was horrible

Paul Scholes column

I don't believe Evans was spitting at Cissé. It was a reflex. But what the Newcastle striker did next was horrible
Miguel Layun interview: From the Azteca to Vicarage Road with a million followers

From the Azteca to Vicarage Road with a million followers

Miguel Layun is a star in Mexico where he was criticised for leaving to join Watford. But he says he sees the bigger picture
Frank Warren column: Amir Khan ready to meet winner of Floyd Mayweather v Manny Pacquiao

Khan ready to meet winner of Mayweather v Pacquiao

The Bolton fighter is unlikely to take on Kell Brook with two superstar opponents on the horizon, says Frank Warren
War with Isis: Iraq's government fights to win back Tikrit from militants - but then what?

Baghdad fights to win back Tikrit from Isis – but then what?

Patrick Cockburn reports from Kirkuk on a conflict which sectarianism has made intractable