Arts and Entertainment Jared Leto in 'Dallas Buyers Club'

When will TV and film start opening the door to transgender actors, asks Paris Lees

Diet has long informed how society perceives weight and body image

In the last 50 years our diet has been transformed. From boiled beef and carrots to a Big Mac and fries, we have moved from a world of shortages and post-war rationing to one of overabundance.

The moai, giant stone statues that line the Easter Island coast

This week's big questions: Can ancient tribes teach us anything? Are we doomed, like Easter Islanders, to extinction?

This week's questions are answered by Jared Diamond, an American scientist and the author of the bestselling ‘Guns, Germs, and Steel

Spencer Cox: Activist who helped bring an anti-Aids drug on to the market

Spencer Cox, who died in New York of Aids-related causes on 18 December aged 44, was an Aids activist who helped form an organisation to boost treatment research and recently appeared in a documentary about an Aids coalition.

Sir Ian McKellen was memerising in his reading of The Prelude by Wordsworth

Sir Ian McKellen speaks of prostate cancer shock

Sir Ian McKellen has told how he feared the worst when he was diagnosed with prostate cancer.

Anne Hathaway has tried extreme – and extremely unpleasant – eating regimes to lose weight for a part

Hollywood roles to diet for

If you find it hard to lose weight, be glad you're not an actor. Playing an emaciated waif can mean mad, bad and dangerous eating plans, says Gillian Orr

Books of the Year 2012: Celebrity

From art to sport, poetry to nature, travel to food, history to music: our writers select the best of the year’s books in a comprehensive guide to the highlights in every shade of the literary spectrum – except grey

David Cecil in a Kampala court cell after his arrest earlier this month

Together the voices of reason and care can bring sexual equality to an ever more draconian Uganda

Our writer, who saw an unlikely champion of gay rights fight for his beliefs in an African court, says that there are grounds for optimism in the battle for equality there

World AIDS Day: Health problems do not discriminate based on where people live

It's not just low income countries that have a problem.

Editorial: Aids treatment is a success story, but more must be done

In 2000, a year's course of anti-retroviral drugs cost $10,000 and projections caused consternation even in Western countries coping with a few thousand cases of HIV. The idea that treatment might be rolled out to millions in the developing world seemed a pipe dream.

Elderly women in Kasarika, a village with one of the highest rates of HIV in Malawi

World Aids Day: The curse of being one of the witches of Malawi

An Aids awareness scheme is teaching villagers HIV is an illness, and not caused by witchcraft. By Hazel Southam in Kasarika

A torch light rally is held in Kolkata yesterday ahead of World Aids Day

World Aids Day: ‘Turning the tide will fail if funding is not increased’

Three decades on from the start of the Aids pandemic, the main global agencies are uncertain whether to be cheerful or gloomy about prospects for the worst disease of modern times .

Patient co-ordinator Chris is one of the longest living survivors of HIV in Britain

World Aids Day: Suddenly I had a future, the relief was immense

Patient co-ordinator Chris is one of the longest living survivors of HIV in Britain. He speaks to Patrick Strudwick

World Aids Day: I met Enoch. Three years ago he couldn't stand up. Now his life is transformed. The cost? 23p a day

I choose not to listen to the cynics, whose philosophical opposition to aid bewilders me

World AIDS Day: A race against time as HIV treatment is cut

Anti-retrovirals are vital in improving and saving the lives of children with HIV.

The Vivisector: Group show curated by Todd Levin, Sprüth Magers, London

A naked doll with long synthetic hair greets the visitor to this inspired exhibition, which explores "the idea of opening up and exposing a living body".

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Blairites be warned, this could be the moment Labour turns into Syriza

Andrew Grice: Inside Westminster

Blairites be warned, this could be the moment Labour turns into Syriza
HMS Victory: The mystery of Britain's worst naval disaster is finally solved - 271 years later

The mystery of Britain's worst naval disaster is finally solved - 271 years later

Exclusive: David Keys reveals the research that finally explains why HMS Victory went down with the loss of 1,100 lives
Survivors of the Nagasaki atomic bomb attack: Japan must not abandon its post-war pacifism

'I saw people so injured you couldn't tell if they were dead or alive'

Nagasaki survivors on why Japan must not abandon its post-war pacifism
Jon Stewart: The voice of Democrats who felt Obama had failed to deliver on his 'Yes We Can' slogan, and the voter he tried hardest to keep onside

The voter Obama tried hardest to keep onside

Outgoing The Daily Show host, Jon Stewart, became the voice of Democrats who felt the President had failed to deliver on his ‘Yes We Can’ slogan. Tim Walker charts the ups and downs of their 10-year relationship on screen
RuPaul interview: The drag star on being inspired by Bowie, never fitting in, and saying the first thing that comes into your head

RuPaul interview

The drag star on being inspired by Bowie, never fitting in, and saying the first thing that comes into your head
Secrets of comedy couples: What's it like when both you and your partner are stand-ups?

Secrets of comedy couples

What's it like when both you and your partner are stand-ups?
Satya Nadella: As Windows 10 is launched can he return Microsoft to its former glory?

Satya Nadella: The man to clean up for Windows?

While Microsoft's founders spend their billions, the once-invincible tech company's new boss is trying to save it
The best swimwear for men: From trunks to shorts, make a splash this summer

The best swimwear for men

From trunks to shorts, make a splash this summer
Mark Hix recipes: Our chef tries his hand at a spot of summer foraging

Mark Hix goes summer foraging

 A dinner party doesn't have to mean a trip to the supermarket
Ashes 2015: With an audacious flourish, home hero Ian Bell ends all debate

With an audacious flourish, the home hero ends all debate

Ian Bell advances to Trent Bridge next week almost as undroppable as Alastair Cook and Joe Root, a cornerstone of England's new thinking, says Kevin Garside
Aaron Ramsey interview: Wales midfielder determined to be centre of attention for Arsenal this season

Aaron Ramsey interview

Wales midfielder determined to be centre of attention for Arsenal this season
Community Shield: Arsene Wenger needs to strike first blow in rivalry with Jose Mourinho

Community Shield gives Wenger chance to strike first blow in rivalry with Mourinho

As long as the Arsenal manager's run of games without a win over his Chelsea counterpart continues it will continue to dominate the narrative around the two men
The unlikely rise of AFC Bournemouth - and what it says about English life

Unlikely rise of AFC Bournemouth

Bournemouth’s elevation to football’s top tier is one of the most improbable of recent times. But it’s illustrative of deeper and wider changes in English life
A Very British Coup, part two: New novel in pipeline as Jeremy Corbyn's rise inspires sequel

A Very British Coup, part two

New novel in pipeline as Jeremy Corbyn's rise inspires sequel
Philae lander data show comets could have brought 'building blocks of life' to Earth

Philae lander data show comets could have brought 'building blocks of life' to Earth

Icy dust layer holds organic compounds similar to those found in living organisms