Arts and Entertainment Jared Leto in 'Dallas Buyers Club'

When will TV and film start opening the door to transgender actors, asks Paris Lees

The new method of gene therapy makes it simple and easy to edit any desired part of the DNA molecule

CRISPR gene therapy: Scientists call for more public debate around breakthrough technique

Scientists are calling for a wider public debate on a new development in genetics that could allow the simple and accurate manipulation of the human genome, as revealed yesterday by The Independent.

Annie Lennox wins Music Industry Trusts Award for 'outstanding contribution'

Tributes flood in for the Eurythmics star, who won for her extraordinary contribution to British music and dedication to charity work

Prolific paedophile is HIV positive

Sex offender and accomplice groomed young boys online before filming their sexual abuse

China plan to ban HIV patients from public baths comes under attack

UN urges Chinese government to scrap the proposal

HIV: Winning abroad, losing at home

As treatment for the virus improves in the developing world, UK attitudes towards the epidemic are slipping into a steady and serene regression

Mike Barton says 'addicts need to be treated, cared for and encouraged. They do not need to be criminalised'

Give addicts heroin on the NHS to stop gangs profiting from drugs, says top police officer

Durham Chief Constable Mike Barton says UK has not learned the lessons from history over prohibition

Gambia: Gays are biggest threat to world, President Yahya Jammeh tells UN

President Yahya Jammeh used his address to the United Nations General Assembly to attack gays and lesbians, calling homosexuality one of the three “biggest threats to human existence.”

Electron microscope image of the Aids virus

Global HIV/Aids epidemic 'could be over by 2030' as infection rates drop by a third

But figures among men who have sex with men 'still out of control'

How nets save lives: UK pledges £1bn to battle Malaria and other preventable diseases

To think that every minute, a parent somewhere loses their son or daughter to malaria because of a mosquito bite is heart-wrenching

5.3 million people are now receiving antiretroviral therapy to treat HIV

UK pledges £1bn to battle AIDS, TB and Malaria – some of world's most devastating preventable diseases

Only the USA will pay more on global health  - with our contribution aiming to save 'a life every three minutes'

Anger as Bangladesh refuses to decriminalise homosexuality

Gay rights activists have criticised the Bangladeshi government after it rejected recommendations to remove a clause in its penal code which criminalises gay relationships.

Researchers have found that one-to-one care with the same midwife is a lot cheaper and safer for mothers-to-be

Maternity survey shows one-to-one care from the same midwife is safer – and cheaper

Lancet study will add pressure on ministers to meet pledge on maternity services

Ppackages of condoms readily available on the set as actors prepare to film a porn scene in California

California porn actors free not to use condoms in sex scenes after state fails to pass bill - despite spate of HIV cases

Porn safe-sex law voted down after filmmakers threaten to leave state

Strain of HIV virus found in monkeys is cleared by vaccine

Vaccine could be used on humans in clinical trials within two years

Porn filming suspended in US after fourth case of HIV

Last month, work was suspended after actress Cameron Bay tested positive

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Pompeii, Capri & the Bay of Naples
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Lake Garda
Minoan Crete and Santorini
Prices correct as of 17 April 2015
Where the spooks get their coffee fix: The busiest Starbucks in the US is also the most secretive

The secret CIA Starbucks

The coffee shop is deep inside the agency's forested Virginia compound
Revealed: How the Establishment closed ranks over fallout from Loch Ness Monster 'sighting'

How the Establishment closed ranks over fallout from Nessie 'sighting'

The Natural History Museum's chief scientist was dismissed for declaring he had found the monster
One million Britons using food banks, according to Trussell Trust

One million Britons using food banks

Huge surge in number of families dependent on emergency food aid
Excavation at Italian cafe to fix rising damp unearths 2,500 years of history in 3,000 amazing objects

2,500 years of history in 3,000 amazing objects

Excavation at Italian cafe to fix rising damp unearths trove
The Hubble Space Telescope's amazing journey, 25 years on

The Hubble Space Telescope's amazing journey 25 years on

The space telescope was seen as a costly flop on its first release
Did Conservative peer Lord Ashcroft quit the House of Lords to become a non-dom?

Did Lord Ashcroft quit the House of Lords to become a non-dom?

A document seen by The Independent shows that a week after he resigned from the Lords he sold 350,000 shares in an American company - netting him $11.2m
Apple's ethnic emojis are being used to make racist comments on social media

Ethnic emojis used in racist comments

They were intended to promote harmony, but have achieved the opposite
Sir Kenneth Branagh interview: 'My bones are in the theatre'

Sir Kenneth Branagh: 'My bones are in the theatre'

The actor-turned-director’s new company will stage five plays from October – including works by Shakespeare and John Osborne
The sloth is now the face (and furry body) of three big advertising campaigns

The sloth is the face of three ad campaigns

Priya Elan discovers why slow and sleepy wins the race for brands in need of a new image
How to run a restaurant: As two newbies discovered, there's more to it than good food

How to run a restaurant

As two newbies discovered, there's more to it than good food
Record Store Day: Remembering an era when buying and selling discs were labours of love

Record Store Day: The vinyl countdown

For Lois Pryce, working in a record shop was a dream job - until the bean counters ruined it
Usher, Mary J Blige and Will.i.am to give free concert as part of the Global Poverty Project

Mary J Blige and Will.i.am to give free concert

The concert in Washington is part of the Global Citizen project, which aims to encourage young people to donate to charity
10 best tote bags

Accessorise with a stylish shopper this spring: 10 best tote bags

We find carriers with room for all your essentials (and a bit more)
Paul Scholes column: I hear Manchester City are closing on Pep Guardiola for next summer – but I'd also love to see Jürgen Klopp managing in England

Paul Scholes column

I hear Manchester City are closing on Pep Guardiola for next summer – but I'd also love to see Jürgen Klopp managing in England
Jessica Ennis-Hill: 'I just want to give it my best shot'

Jessica Ennis-Hill: 'I just want to give it my best shot'

The heptathlete has gone from the toast of the nation to being a sleep-deprived mum - but she’s ready to compete again. She just doesn't know how well she'll do...