Arts and Entertainment Jared Leto in 'Dallas Buyers Club'

When will TV and film start opening the door to transgender actors, asks Paris Lees

The new method of gene therapy makes it simple and easy to edit any desired part of the DNA molecule

CRISPR gene therapy: Scientists call for more public debate around breakthrough technique

Scientists are calling for a wider public debate on a new development in genetics that could allow the simple and accurate manipulation of the human genome, as revealed yesterday by The Independent.

Annie Lennox wins Music Industry Trusts Award for 'outstanding contribution'

Tributes flood in for the Eurythmics star, who won for her extraordinary contribution to British music and dedication to charity work

Prolific paedophile is HIV positive

Sex offender and accomplice groomed young boys online before filming their sexual abuse

China plan to ban HIV patients from public baths comes under attack

UN urges Chinese government to scrap the proposal

HIV: Winning abroad, losing at home

As treatment for the virus improves in the developing world, UK attitudes towards the epidemic are slipping into a steady and serene regression

Mike Barton says 'addicts need to be treated, cared for and encouraged. They do not need to be criminalised'

Give addicts heroin on the NHS to stop gangs profiting from drugs, says top police officer

Durham Chief Constable Mike Barton says UK has not learned the lessons from history over prohibition

Gambia: Gays are biggest threat to world, President Yahya Jammeh tells UN

President Yahya Jammeh used his address to the United Nations General Assembly to attack gays and lesbians, calling homosexuality one of the three “biggest threats to human existence.”

Electron microscope image of the Aids virus

Global HIV/Aids epidemic 'could be over by 2030' as infection rates drop by a third

But figures among men who have sex with men 'still out of control'

How nets save lives: UK pledges £1bn to battle Malaria and other preventable diseases

To think that every minute, a parent somewhere loses their son or daughter to malaria because of a mosquito bite is heart-wrenching

5.3 million people are now receiving antiretroviral therapy to treat HIV

UK pledges £1bn to battle AIDS, TB and Malaria – some of world's most devastating preventable diseases

Only the USA will pay more on global health  - with our contribution aiming to save 'a life every three minutes'

Anger as Bangladesh refuses to decriminalise homosexuality

Gay rights activists have criticised the Bangladeshi government after it rejected recommendations to remove a clause in its penal code which criminalises gay relationships.

Researchers have found that one-to-one care with the same midwife is a lot cheaper and safer for mothers-to-be

Maternity survey shows one-to-one care from the same midwife is safer – and cheaper

Lancet study will add pressure on ministers to meet pledge on maternity services

Ppackages of condoms readily available on the set as actors prepare to film a porn scene in California

California porn actors free not to use condoms in sex scenes after state fails to pass bill - despite spate of HIV cases

Porn safe-sex law voted down after filmmakers threaten to leave state

Strain of HIV virus found in monkeys is cleared by vaccine

Vaccine could be used on humans in clinical trials within two years

Porn filming suspended in US after fourth case of HIV

Last month, work was suspended after actress Cameron Bay tested positive

Arts and Entertainment
Gregg Wallace in Summer's Supermarket Secrets
tv All of this year's 15 contestants have now been named
Arts and Entertainment
Inside the gallery at Frederick Bremer School in Walthamstow
tvSimon Usborne goes behind-the-scenes to watch the latest series
Life and Style
A picture taken on January 12, 2011 shows sex shops at the Paris district of Pigalle.
newsThe industry's trade body issued the moratorium on Friday
News
Winchester College Football (universally known as Winkies) is designed to make athletic skill all but irrelevant
Life...arcane public school games explained
Arts and Entertainment
Could we see Iain back in the Bake Off tent next week?
tv Contestant teased Newsnight viewers on potential reappearance
Life and Style
Silvia says of her famous creation: 'I never stopped wearing it. Because I like to wear things when they are off the radar'
fashionThe fashion house celebrated fifteen years of the punchy pouch with a weighty tome
News
i100(and it's got nothing to do with the Great British Bake Off)
News
Angelina Jolie with her father Jon Voight
peopleAsked whether he was upset not to be invited, he responded by saying he was busy with the Emmy Awards
News
Bill Kerr has died aged 92
peopleBill Kerr appeared in Hancock’s Half Hour and later worked alongside Spike Milligan and Peter Sellers
News
news It's not just the world that's a mess at the moment...
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Day In a Page

Burgundy, the River Rhone & Provence – MS Swiss Corona - seven nights from £999pp
Lake Maggiore, Orta and the Matterhorn – seven nights from £899pp
Sicily – seven nights from £939pp
Pompeii, Capri and the Bay of Naples - seven nights from £799pp
Istanbul Ephesus & Troy – six nights from £859pp
Mary Rose – two nights from £319pp
Ukraine crisis: The phoney war is over as Russian troops and armour pour across the border

The phoney war is over

Russian troops and armour pour into Ukraine
Potatoes could be off the menu as crop pests threaten UK

Potatoes could be off the menu as crop pests threaten UK

The world’s entire food system is under attack - and Britain is most at risk, according to a new study
Gangnam smile: why the Chinese are flocking to South Korea to buy a new face

Gangnam smile: why the Chinese are flocking to South Korea to buy a new face

Seoul's plastic surgery industry is booming thanks to the popularity of the K-Pop look
From Mozart to Orson Welles: Creative geniuses who peaked too soon

Creative geniuses who peaked too soon

After the death of Sandy Wilson, 90, who wrote his only hit musical in his twenties, John Walsh wonders what it's like to peak too soon and go on to live a life more ordinary
Caught in the crossfire of a cyber Cold War

Caught in the crossfire of a cyber Cold War

Fears are mounting that Vladimir Putin has instructed hackers to target banks like JP Morgan
Salomé's feminine wiles have inspired writers, painters and musicians for 2,000 years

Salomé: A head for seduction

Salomé's feminine wiles have inspired writers, painters and musicians for 2,000 years. Now audiences can meet the Biblical femme fatale in two new stage and screen projects
From Bram Stoker to Stanley Kubrick, the British Library's latest exhibition celebrates all things Gothic

British Library celebrates all things Gothic

Forthcoming exhibition Terror and Wonder: The Gothic Imagination will be the UK's largest ever celebration of Gothic literature
The Hard Rock Café's owners are embroiled in a bitter legal dispute - but is the restaurant chain worth fighting for?

Is the Hard Rock Café worth fighting for?

The restaurant chain's owners are currently embroiled in a bitter legal dispute
Caribbean cuisine is becoming increasingly popular in the UK ... and there's more to it than jerk chicken at carnival

In search of Caribbean soul food

Caribbean cuisine is becoming increasingly popular in the UK ... and there's more to it than jerk chicken at carnival
11 best face powders

11 best face powders

Sweep away shiny skin with our pick of the best pressed and loose powder bases
England vs Norway: Roy Hodgson's hands tied by exploding top flight

Roy Hodgson's hands tied by exploding top flight

Lack of Englishmen at leading Premier League clubs leaves manager hamstrung
Angel Di Maria and Cristiano Ronaldo: A tale of two Manchester United No 7s

Di Maria and Ronaldo: A tale of two Manchester United No 7s

They both inherited the iconic shirt at Old Trafford, but the £59.7m new boy is joining a club in a very different state
Israel-Gaza conflict: No victory for Israel despite weeks of death and devastation

Robert Fisk: No victory for Israel despite weeks of devastation

Palestinians have won: they are still in Gaza, and Hamas is still there
Mary Beard writes character reference for Twitter troll who called her a 'slut'

Unlikely friends: Mary Beard and the troll who called her a ‘filthy old slut’

The Cambridge University classicist even wrote the student a character reference
America’s new apartheid: Prosperous white districts are choosing to break away from black cities and go it alone

America’s new apartheid

Prosperous white districts are choosing to break away from black cities and go it alone