Arts and Entertainment Jared Leto in 'Dallas Buyers Club'

When will TV and film start opening the door to transgender actors, asks Paris Lees

The new method of gene therapy makes it simple and easy to edit any desired part of the DNA molecule

CRISPR gene therapy: Scientists call for more public debate around breakthrough technique

Scientists are calling for a wider public debate on a new development in genetics that could allow the simple and accurate manipulation of the human genome, as revealed yesterday by The Independent.

Annie Lennox wins Music Industry Trusts Award for 'outstanding contribution'

Tributes flood in for the Eurythmics star, who won for her extraordinary contribution to British music and dedication to charity work

Prolific paedophile is HIV positive

Sex offender and accomplice groomed young boys online before filming their sexual abuse

China plan to ban HIV patients from public baths comes under attack

UN urges Chinese government to scrap the proposal

HIV: Winning abroad, losing at home

As treatment for the virus improves in the developing world, UK attitudes towards the epidemic are slipping into a steady and serene regression

Mike Barton says 'addicts need to be treated, cared for and encouraged. They do not need to be criminalised'

Give addicts heroin on the NHS to stop gangs profiting from drugs, says top police officer

Durham Chief Constable Mike Barton says UK has not learned the lessons from history over prohibition

Gambia: Gays are biggest threat to world, President Yahya Jammeh tells UN

President Yahya Jammeh used his address to the United Nations General Assembly to attack gays and lesbians, calling homosexuality one of the three “biggest threats to human existence.”

Electron microscope image of the Aids virus

Global HIV/Aids epidemic 'could be over by 2030' as infection rates drop by a third

But figures among men who have sex with men 'still out of control'

How nets save lives: UK pledges £1bn to battle Malaria and other preventable diseases

To think that every minute, a parent somewhere loses their son or daughter to malaria because of a mosquito bite is heart-wrenching

5.3 million people are now receiving antiretroviral therapy to treat HIV

UK pledges £1bn to battle AIDS, TB and Malaria – some of world's most devastating preventable diseases

Only the USA will pay more on global health  - with our contribution aiming to save 'a life every three minutes'

Anger as Bangladesh refuses to decriminalise homosexuality

Gay rights activists have criticised the Bangladeshi government after it rejected recommendations to remove a clause in its penal code which criminalises gay relationships.

Researchers have found that one-to-one care with the same midwife is a lot cheaper and safer for mothers-to-be

Maternity survey shows one-to-one care from the same midwife is safer – and cheaper

Lancet study will add pressure on ministers to meet pledge on maternity services

Ppackages of condoms readily available on the set as actors prepare to film a porn scene in California

California porn actors free not to use condoms in sex scenes after state fails to pass bill - despite spate of HIV cases

Porn safe-sex law voted down after filmmakers threaten to leave state

Strain of HIV virus found in monkeys is cleared by vaccine

Vaccine could be used on humans in clinical trials within two years

Porn filming suspended in US after fourth case of HIV

Last month, work was suspended after actress Cameron Bay tested positive

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Day In a Page

Independent Travel
Pompeii, Capri & the Bay of Naples
Dubrovnik, the Dalmatian Coast & Montenegro
Burgundy, the River Rhone & Provence
Lisbon, Oporto and the Douro Valley
Lake Garda, Venice & Verona
Spain
Prices correct as of 23 January 2015
Syria crisis: Celebrities call on David Cameron to take more refugees as one young mother tells of torture by Assad regime

Celebrities call on David Cameron to take more Syrian refugees

One young mother tells of torture by Assad regime
The enemy within: People who hear voices in their heads are being encouraged to talk back – with promising results

The enemy within

People who hear voices in their heads are being encouraged to talk back
'In Auschwitz you got used to anything'

'In Auschwitz you got used to anything'

Survivors of the Nazi concentration camp remember its horror, 70 years on
Autumn/winter menswear 2015: The uniforms that make up modern life come to the fore

Autumn/winter menswear 2015

The uniforms that make up modern life come to the fore
'I'm gay, and plan to fight military homophobia'

'I'm gay, and plan to fight military homophobia'

Army general planning to come out
Iraq invasion 2003: The bloody warnings six wise men gave to Tony Blair as he prepared to launch poorly planned campaign

What the six wise men told Tony Blair

Months before the invasion of Iraq in 2003, experts sought to warn the PM about his plans. Here, four of them recall that day
25 years of The Independent on Sunday: The stories, the writers and the changes over the last quarter of a century

25 years of The Independent on Sunday

The stories, the writers and the changes over the last quarter of a century
Homeless Veterans appeal: 'Really caring is a dangerous emotion in this kind of work'

Homeless Veterans appeal

As head of The Soldiers' Charity, Martin Rutledge has to temper compassion with realism. He tells Chris Green how his Army career prepared him
Wu-Tang Clan and The Sexual Objects offer fans a chance to own the only copies of their latest albums

Smash hit go under the hammer

It's nice to pick up a new record once in a while, but the purchasers of two latest releases can go a step further - by buying the only copy
Geeks who rocked the world: Documentary looks back at origins of the computer-games industry

The geeks who rocked the world

A new documentary looks back at origins of the computer-games industry
Belle & Sebastian interview: Stuart Murdoch reveals how the band is taking a new direction

Belle & Sebastian is taking a new direction

Twenty years ago, Belle & Sebastian was a fey indie band from Glasgow. It still is – except today, as prime mover Stuart Murdoch admits, it has a global cult following, from Hollywood to South Korea
America: Land of the free, home of the political dynasty

America: Land of the free, home of the political dynasty

These days in the US things are pretty much stuck where they are, both in politics and society at large, says Rupert Cornwell
A graphic history of US civil rights – in comic book form

A graphic history of US civil rights – in comic book form

A veteran of the Fifties campaigns is inspiring a new generation of activists
Winston Churchill: the enigma of a British hero

Winston Churchill: the enigma of a British hero

A C Benson called him 'a horrid little fellow', George Orwell would have shot him, but what a giant he seems now, says DJ Taylor
Growing mussels: Precious freshwater shellfish are thriving in a unique green project

Growing mussels

Precious freshwater shellfish are thriving in a unique green project