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Tyler Doohan went back inside the bedroom of a burning trailer to try and save his disabled grandfather

Frank Berger: Inventor of the first tranquilliser

Frank Berger spawned a billion-pound industry when he invented meprobamate, the first tranquilliser. Until then the nearest drugs were barbiturates, which sedated rather than calmed and were often used by suicides. There was a huge need for a sedating drug that remained safe in overdose, and for a decade mebrobamate filled that gap. It was sold in the UK as Equanil and – combined with a painkiller – as Equagesic.

New hope in fight against 'Lorenzo's Oil' disease

A dramatic breakthrough in the possible treatment of childhood diseases of the nervous system – including the disorder featured in the film Lorenzo's Oil – was announced by scientists in America yesterday.

Hey nonny no, no, no: Goths and pagans are reinventing morris dancing

Why the newcomers are putting the fear of God into the traditionalists

Dickens family seek to overturn writer's dying wish for no memorials

In 1869, a year before Charles Dickens died, he wrote in his will that he wanted to be remembered for his work alone. No plaques, no statues, "no monument memorial or testimonial whatever" were to be allowed to commemorate the life of one of Britain's greatest authors.

Leading article: A tale of two arguments

When a biography of a writer appears, the cry often goes up that what counts is the art not the life. And if the writer is living, then very often he or she will have objected to being written about, or at the very least refused to co-operate with the project.

Design & Interiors: Stokesay Court

It wasn't only Keira Knightley who ravished the eye in 'Atonement'. The film's setting left us swooning too.

Clash of cultures: the screaming minarets of Oxford

A plan to call Muslims to prayer with a loudspeaker has divided opinion in Britain's oldest university town. By Andy McSmith

Dreda Say Mitchell: It's not only white people fleeing our city centres

It doesn't feature on Location, Location, Location but "race" is back in the news as a factor in where people choose to live. Trevor Phillips, who chairs the Equality and Human Rights Commission, has reiterated his concerns that Britain could become a segregated society. The Bishop of Rochester thinks some Muslim areas are becoming no-go areas for outsiders, while others are comparing some of England's northern towns to Belfast. But is it actually true?

Enterprise of Exiles and Gloucester promises an enthralling collision

If the Lord Mayor's Show in Cardiff turns out to be a forward-dominated affair - Munster do not possess a back division worthy of the name; Biarritz have an attacking unit boasting all the talents, but prefer not to use it - what comes after may prove the perfect antidote. Tomorrow's European Challenge Cup final between Gloucester and London Irish at the Twickenham Stoop features two sides at the forefront of what might be called English rugby's All Black movement, which embraces the theory that tries are better than penalties, that handling is better than kicking, that one crisp miss-pass in midfield is better than two months' worth of rolling mauls.

Nell Gwyn, by Charles Beauclerk

Reheated queen of tarts

School Standards: Bouncing back: from failing list to the `magnificent seven'

A "MAGNIFICENT seven" schools were hailed yesterday as the most improved in England after moving from Ofsted's failing list to be named among the country's most outstanding.
Arts & Entertainment
The Honesty Policy is a group of anonymous Muslims who believe that the community needs a space to express itself without shame or judgement
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Arts & Entertainment
Martin Freeman as Lester Nygaard in the TV adaptation of 'Fargo'
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News
Waitrose will be bringing in more manned tills
newsOverheard in Waitrose: documenting the chatter in 'Britain's poshest supermarket'
Sport
Pablo Larrazabal jumps into a pond in Kuala Lumpur to escape a swarm of hornets
videoSpain's Pablo Larrazabal's had a refreshing solution
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Who makes you happy?
happy listSend your nominations now for the Independent on Sunday Happy List
Arts & Entertainment
tvIt might all be getting a bit much, but this is still the some of the finest TV ever made, says Grace Dent
Sport
Jonathan Trott will take a second break from cricket after suffering a repeat of the stress-related illness that forced him out of the Ashes tour of Australia
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Life & Style
life
Life & Style
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Ian Anderson, the leader of British rock band Jethro Tull, (right) and British guitar player Martin Barre (left) perform on stage
musicJethro Tull frontman leads ‘prog rock’ revival
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How I brokered a peace deal with Robert Mugabe: Roy Agyemang reveals the delicate diplomacy needed to get Zimbabwe’s President to sit down with the BBC

How I brokered a peace deal with Robert Mugabe

Roy Agyemang reveals the delicate diplomacy needed to get Zimbabwe’s President to sit down with the BBC
Video of British Muslims dancing to Pharrell Williams's hit Happy attacked as 'sinful'

British Muslims's Happy video attacked as 'sinful'

The four-minute clip by Honesty Policy has had more than 300,000 hits on YouTube
Church of England-raised Michael Williams describes the unexpected joys in learning about his family's Jewish faith

Michael Williams: Do as I do, not as I pray

Church of England-raised Williams describes the unexpected joys in learning about his family's Jewish faith
A History of the First World War in 100 moments: A visit to the Front Line by the Prime Minister's wife

A History of the First World War in 100 moments

A visit to the Front Line by the Prime Minister's wife
Comedian Jenny Collier: 'Sexism I experienced on stand-up circuit should be extinct'

Jenny Collier: 'Sexism on stand-up circuit should be extinct'

The comedian's appearance at a show on the eve of International Women's Day was cancelled because they had "too many women" on the bill
Cannes Film Festival: Ken Loach and Mike Leigh to fight it out for the Palme d'Or

Cannes Film Festival

Ken Loach and Mike Leigh to fight it out for the Palme d'Or
The concept album makes surprise top ten return with neolithic opus from Jethro Tull's Ian Anderson

The concept album makes surprise top ten return

Neolithic opus from Jethro Tull's Ian Anderson is unexpected success
Lichen is the surprise new ingredient on fine-dining menus, thanks to our love of Scandinavian and Indian cuisines

Lichen is surprise new ingredient on fine-dining menus

Emily Jupp discovers how it can give a unique, smoky flavour to our cooking
10 best baking books

10 best baking books

Planning a spot of baking this bank holiday weekend? From old favourites to new releases, here’s ten cookbooks for you
Jury still out on Manchester City boss Manuel Pellegrini

Jury still out on Pellegrini

Draw with Sunderland raises questions over Manchester City manager's ability to motivate and unify his players
Ben Stokes: 'Punching lockers isn't way forward'

Ben Stokes: 'Punching lockers isn't way forward'

The all-rounder has been hailed as future star after Ashes debut but incident in Caribbean added to doubts about discipline. Jon Culley meets a man looking to control his emotions
Mark Johnston: First £1 million jackpot spurs him on

Mark Johnston: First £1 million jackpot spurs him on

The most prize money ever at an All-Weather race day is up for grabs at Lingfield on Friday, and the record-breaking trainer tells Jon Freeman how times have changed
Ricky Gervais: 'People are waiting for me to fail. If you think it's awful, then just don't watch it'

Ricky Gervais: 'People are waiting for me to fail'

As the second series of his divisive sitcom 'Derek' hits screens, the comedian tells James Rampton why he'll never bow to the critics who habitually circle his work
Mad Men series 7, TV review: The suits are still sharp, but Don Draper has lost his edge

Mad Men returns for a final fling

The suits are still sharp, but Don Draper has lost his edge
Google finds a lift into space will never get off the ground as there is no material strong enough for a cable from Earth into orbit

Google finds a lift into space will never get off the ground

Technology giant’s scientists say there is no material strong enough for a cable from Earth into orbit