Sport Peyton Manning broke Tom Brady's record for touchdown passes in a season

Devastated by injury and dumped by his beloved team, one of the NFL’s all-time great quarterbacks is back in business and breaking records

Scientists are closer to building a biological computer after they managed to make a transistor from DNA and RNA

Biological computer that 'lives' inside the body comes one step closer as scientists make transistor out of DNA and RNA

Finding could lead to new biodegradable devices based on living cells that are capable of detecting changes in the environment

Cosmic! Scientists clear up one of large unsolved puzzles about our Universe

Scientists have solved the mystery of cosmic rays, a stream of highly-energetic sub-atomic particles that pervades the Universe and is responsible for much of the extra radiation dose received by airline passengers.

Judging by the complaints, sanctions are inflicting pain

I co-ordinated the UN Panel of Experts charged with improving implementation of the Security Council sanctions for a year and am often asked how effective they are. Clearly they have not halted the North Korean nuclear programme but they have almost certainly slowed it down and, judging by the constant shrill complaints, they are certainly inflicting pain. Perhaps not least, the North Koreans regard them as a humiliation – they bitterly resent being treated as a pariah and crave respectability.

Toe pokes: Vibram FiveFingers shoes

To boldly toe: ToPo Athletic split foot trainers are more science than gimmick

The man behind the world's weirdest running shoes is back with a new hi-tech trainer. Simon Usborne laces up

Missing person: The Manti Te’o headlines went from hero to hoax after his heart-warming tale turned into a whodunit

American Football: Solved - the case of the girlfriend who never was

As mysteries go, the one involving the Notre Dame linebacker Manti Te'o and his "dead" girlfriend takes some beating. Yesterday, like the next chapter in a detective novel, it unveiled another twist which will only serve to ratchet up the interest in this bizarre story.

Commitment to social justice: Swartz in December 2012

Aaron Swartz: Campaigner for internet freedom

Aaron Swartz was a campaigner for internet freedom and a software developer who made an enormous impact during his 26 short years on the planet. His campaigning work and direct action for freedom of information had led him into frequent conflict with the authorities, with the result that, at the time of his death, he faced 13 felony charges for which he was due to stand trial within the coming months.

David Cameron’s official 'blue sky' thinker Steve Hilton

Cameron’s Mr Blue Sky: how we found out our own policies from the papers

On sabbatical in California, Steve Hilton reveals ‘horror’ at how No 10 really works

This week's wackiest stories from the web: Stupid evolution and the first burger in space

If you have sex in public, but no one is watching, is it still obscene? Plus bones of ancient giant discovered and that regrettable Romney face tattoo

Brain imaging, such as this pictured at the Leibniz Institute for Neurobiology, is proving vital for understanding how the mind works

Identifying the brain's own facial recognition system

The ability to recognize faces is so important in humans that the brain appears to have an area solely devoted to the task: the fusiform gyrus.

The iPhone: Can't live without it

One teenager faces the ultimate challenge: A week without her iPhone

I just spent a week without one of the most important things in my life. It's something that I never go anywhere without, that I talk to when I'm lonely, that I stare at for hours upon end, day after day. It's there for me when my friends are not. It never argues with me or makes me feel bad about myself. I love it dearly and I can make it tell me that it loves me, too: My iPhone.

Awe therapy could 'improve our mental health and make us nicer'

A jaw-dropping moment really can make time appear to stand still - or at least slow down, new research suggests.

Stephen Hawking's thoughts... unredacted and unedited

A man like Stephen Hawking, renowned for his complex thinking, might be happy to have scientists read his brainwaves. The Cambridge professor, who suffers from motor neurone disease and is losing his ability to communicate via computer, is working with scientists hoping to read his brain.

Tests on fake retina 'encouraging'

Tests on a device that could restore sight to patients suffering from a common cause of blindness have produced "encouraging" results.

Andrew Luck is one of the names to watch at the NFL draft

American Football: Do believe the hype! NFL draft is the craziest show in town

It is fantasy football come true. Thirty-two teams picking future gridiron superstars live on prime-time television. What's not to like?

Cameron is a touch-screen Tory and totally techno -no surprise he has his own app

What's on Dave's dashboard?

David Cameron now has a special app to run the country. But what else is on his iPad? John Rentoul sneaks an iPeek

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Not even the 'putrid throat' could stop the Ross Poldark swoon-fest'

Not even the 'putrid throat' could stop the Ross Poldark swoon-fest'

How a costume drama became a Sunday night staple
Miliband promises no stamp duty for first-time buyers as he pushes Tories on housing

Miliband promises no stamp duty for first-time buyers

Labour leader pushes Tories on housing
Aviation history is littered with grand failures - from the the Bristol Brabazon to Concorde - but what went wrong with the SuperJumbo?

Aviation history is littered with grand failures

But what went wrong with the SuperJumbo?
Fear of Putin, Islamists and immigration is giving rise to a new generation of Soviet-style 'iron curtains' right across Europe

Fortress Europe?

Fear of Putin, Islamists and immigration is giving rise to a new generation of 'iron curtains'
Never mind what you're wearing, it's what you're reclining on

Never mind what you're wearing

It's what you're reclining on that matters
General Election 2015: Chuka Umunna on the benefits of immigration, humility – and his leader Ed Miliband

Chuka Umunna: A virus of racism runs through Ukip

The shadow business secretary on the benefits of immigration, humility – and his leader Ed Miliband
Yemen crisis: This exotic war will soon become Europe's problem

Yemen's exotic war will soon affect Europe

Terrorism and boatloads of desperate migrants will be the outcome of the Saudi air campaign, says Patrick Cockburn
Marginal Streets project aims to document voters in the run-up to the General Election

Marginal Streets project documents voters

Independent photographers Joseph Fox and Orlando Gili are uploading two portraits of constituents to their website for each day of the campaign
Game of Thrones: Visit the real-life kingdom of Westeros to see where violent history ends and telly tourism begins

The real-life kingdom of Westeros

Is there something a little uncomfortable about Game of Thrones shooting in Northern Ireland?
How to survive a social-media mauling, by the tough women of Twitter

How to survive a Twitter mauling

Mary Beard, Caroline Criado-Perez, Louise Mensch, Bunny La Roche and Courtney Barrasford reveal how to trounce the trolls
Gallipoli centenary: At dawn, the young remember the young who perished in one of the First World War's bloodiest battles

At dawn, the young remember the young

A century ago, soldiers of the Empire – many no more than boys – spilt on to Gallipoli’s beaches. On this 100th Anzac Day, there are personal, poetic tributes to their sacrifice
Dissent is slowly building against the billions spent on presidential campaigns – even among politicians themselves

Follow the money as never before

Dissent is slowly building against the billions spent on presidential campaigns – even among politicians themselves, reports Rupert Cornwell
Samuel West interview: The actor and director on austerity, unionisation, and not mentioning his famous parents

Samuel West interview

The actor and director on austerity, unionisation, and not mentioning his famous parents
General Election 2015: Imagine if the leading political parties were fashion labels

Imagine if the leading political parties were fashion labels

Fashion editor, Alexander Fury, on what the leaders' appearances tell us about them
Phumzile Mlambo-Ngcuka: Home can be the unsafest place for women

Phumzile Mlambo-Ngcuka: Home can be the unsafest place for women

The architect of the HeForShe movement and head of UN Women on the world's failure to combat domestic violence