Sport Peyton Manning broke Tom Brady's record for touchdown passes in a season

Devastated by injury and dumped by his beloved team, one of the NFL’s all-time great quarterbacks is back in business and breaking records

Scientists are closer to building a biological computer after they managed to make a transistor from DNA and RNA

Biological computer that 'lives' inside the body comes one step closer as scientists make transistor out of DNA and RNA

Finding could lead to new biodegradable devices based on living cells that are capable of detecting changes in the environment

Cosmic! Scientists clear up one of large unsolved puzzles about our Universe

Scientists have solved the mystery of cosmic rays, a stream of highly-energetic sub-atomic particles that pervades the Universe and is responsible for much of the extra radiation dose received by airline passengers.

Judging by the complaints, sanctions are inflicting pain

I co-ordinated the UN Panel of Experts charged with improving implementation of the Security Council sanctions for a year and am often asked how effective they are. Clearly they have not halted the North Korean nuclear programme but they have almost certainly slowed it down and, judging by the constant shrill complaints, they are certainly inflicting pain. Perhaps not least, the North Koreans regard them as a humiliation – they bitterly resent being treated as a pariah and crave respectability.

Toe pokes: Vibram FiveFingers shoes

To boldly toe: ToPo Athletic split foot trainers are more science than gimmick

The man behind the world's weirdest running shoes is back with a new hi-tech trainer. Simon Usborne laces up

Missing person: The Manti Te’o headlines went from hero to hoax after his heart-warming tale turned into a whodunit

American Football: Solved - the case of the girlfriend who never was

As mysteries go, the one involving the Notre Dame linebacker Manti Te'o and his "dead" girlfriend takes some beating. Yesterday, like the next chapter in a detective novel, it unveiled another twist which will only serve to ratchet up the interest in this bizarre story.

Commitment to social justice: Swartz in December 2012

Aaron Swartz: Campaigner for internet freedom

Aaron Swartz was a campaigner for internet freedom and a software developer who made an enormous impact during his 26 short years on the planet. His campaigning work and direct action for freedom of information had led him into frequent conflict with the authorities, with the result that, at the time of his death, he faced 13 felony charges for which he was due to stand trial within the coming months.

David Cameron’s official 'blue sky' thinker Steve Hilton

Cameron’s Mr Blue Sky: how we found out our own policies from the papers

On sabbatical in California, Steve Hilton reveals ‘horror’ at how No 10 really works

This week's wackiest stories from the web: Stupid evolution and the first burger in space

If you have sex in public, but no one is watching, is it still obscene? Plus bones of ancient giant discovered and that regrettable Romney face tattoo

Brain imaging, such as this pictured at the Leibniz Institute for Neurobiology, is proving vital for understanding how the mind works

Identifying the brain's own facial recognition system

The ability to recognize faces is so important in humans that the brain appears to have an area solely devoted to the task: the fusiform gyrus.

The iPhone: Can't live without it

One teenager faces the ultimate challenge: A week without her iPhone

I just spent a week without one of the most important things in my life. It's something that I never go anywhere without, that I talk to when I'm lonely, that I stare at for hours upon end, day after day. It's there for me when my friends are not. It never argues with me or makes me feel bad about myself. I love it dearly and I can make it tell me that it loves me, too: My iPhone.

Awe therapy could 'improve our mental health and make us nicer'

A jaw-dropping moment really can make time appear to stand still - or at least slow down, new research suggests.

Stephen Hawking's thoughts... unredacted and unedited

A man like Stephen Hawking, renowned for his complex thinking, might be happy to have scientists read his brainwaves. The Cambridge professor, who suffers from motor neurone disease and is losing his ability to communicate via computer, is working with scientists hoping to read his brain.

Tests on fake retina 'encouraging'

Tests on a device that could restore sight to patients suffering from a common cause of blindness have produced "encouraging" results.

Andrew Luck is one of the names to watch at the NFL draft

American Football: Do believe the hype! NFL draft is the craziest show in town

It is fantasy football come true. Thirty-two teams picking future gridiron superstars live on prime-time television. What's not to like?

Cameron is a touch-screen Tory and totally techno -no surprise he has his own app

What's on Dave's dashboard?

David Cameron now has a special app to run the country. But what else is on his iPad? John Rentoul sneaks an iPeek

Voices
On the last day of campaigning before the polling booths open, the SNP leader has written to voters in a final attempt to convince them to vote for independence
voicesIs a huge gamble on oil keeping the First Minister up at night?
Life and Style
tech

Apple has been hit by complaints about the 1.1GB download

Arts and Entertainment
Pointless host Alexander Armstrong will voice Danger Mouse on CBBC
tv

Much-loved cartoon character returns - without Sir David Jason

Arts and Entertainment
Liam Neeson said he wouldn't
tv

Liam Neeson's Downton dreams

Arts and Entertainment
Actor and director Zach Braff
tv

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i100
Arts and Entertainment
Rosalind Buckland, the inspiration for Cider with Rosie died this week
booksBut what is it like to be the person who inspires a classic work of art?
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News
i100
Arts and Entertainment
The former Doctor Who actor is to play a vicar is search of a wife
film

Matt Smith is set to join cast of the Jane Austen classic - with a twist

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Mystery of the Ground Zero wedding photo

A shot in the dark

Mystery of the wedding photo from Ground Zero
His life, the universe and everything

His life, the universe and everything

New biography sheds light on comic genius of Douglas Adams
Save us from small screen superheroes

Save us from small screen superheroes

Shows like Agents of S.H.I.E.L.D are little more than marketing tools
Reach for the skies

Reach for the skies

From pools to football pitches, rooftop living is looking up
These are the 12 best hotel spas in the UK

12 best hotel spas in the UK

Some hotels go all out on facilities; others stand out for the sheer quality of treatments
These Iranian-controlled Shia militias used to specialise in killing American soldiers. Now they are fighting Isis, backed up by US airstrikes

Widespread fear of Isis is producing strange bedfellows

Iranian-controlled Shia militias that used to kill American soldiers are now fighting Isis, helped by US airstrikes
Topshop goes part Athena poster, part last spring Prada

Topshop goes part Athena poster, part last spring Prada

Shoppers don't come to Topshop for the unique
How to make a Lego masterpiece

How to make a Lego masterpiece

Toy breaks out of the nursery and heads for the gallery
Meet the ‘Endies’ – city dwellers who are too poor to have fun

Meet the ‘Endies’ – city dwellers who are too poor to have fun

Urbanites are cursed with an acronym pointing to Employed but No Disposable Income or Savings
Paisley’s decision to make peace with IRA enemies might remind the Arabs of Sadat

Ian Paisley’s decision to make peace with his IRA enemies

His Save Ulster from Sodomy campaign would surely have been supported by many a Sunni imam
'She was a singer, a superstar, an addict, but to me, her mother, she is simply Amy'

'She was a singer, a superstar, an addict, but to me, her mother, she is simply Amy'

Exclusive extract from Janis Winehouse's poignant new memoir
Is this the role to win Cumberbatch an Oscar?

Is this the role to win Cumberbatch an Oscar?

The Imitation Game, film review
England and Roy Hodgson take a joint step towards redemption in Basel

England and Hodgson take a joint step towards redemption

Welbeck double puts England on the road to Euro 2016
Relatives fight over Vivian Maier’s rare photos

Relatives fight over Vivian Maier’s rare photos

Pictures removed from public view as courts decide ownership
‘Fashion has to be fun. It’s a big business, not a cure for cancer’

‘Fashion has to be fun. It’s a big business, not a cure for cancer’

Donatella Versace at New York Fashion Week