Sport Peyton Manning broke Tom Brady's record for touchdown passes in a season

Devastated by injury and dumped by his beloved team, one of the NFL’s all-time great quarterbacks is back in business and breaking records

Scientists are closer to building a biological computer after they managed to make a transistor from DNA and RNA

Biological computer that 'lives' inside the body comes one step closer as scientists make transistor out of DNA and RNA

Finding could lead to new biodegradable devices based on living cells that are capable of detecting changes in the environment

Cosmic! Scientists clear up one of large unsolved puzzles about our Universe

Scientists have solved the mystery of cosmic rays, a stream of highly-energetic sub-atomic particles that pervades the Universe and is responsible for much of the extra radiation dose received by airline passengers.

Judging by the complaints, sanctions are inflicting pain

I co-ordinated the UN Panel of Experts charged with improving implementation of the Security Council sanctions for a year and am often asked how effective they are. Clearly they have not halted the North Korean nuclear programme but they have almost certainly slowed it down and, judging by the constant shrill complaints, they are certainly inflicting pain. Perhaps not least, the North Koreans regard them as a humiliation – they bitterly resent being treated as a pariah and crave respectability.

Toe pokes: Vibram FiveFingers shoes

To boldly toe: ToPo Athletic split foot trainers are more science than gimmick

The man behind the world's weirdest running shoes is back with a new hi-tech trainer. Simon Usborne laces up

Missing person: The Manti Te’o headlines went from hero to hoax after his heart-warming tale turned into a whodunit

American Football: Solved - the case of the girlfriend who never was

As mysteries go, the one involving the Notre Dame linebacker Manti Te'o and his "dead" girlfriend takes some beating. Yesterday, like the next chapter in a detective novel, it unveiled another twist which will only serve to ratchet up the interest in this bizarre story.

Commitment to social justice: Swartz in December 2012

Aaron Swartz: Campaigner for internet freedom

Aaron Swartz was a campaigner for internet freedom and a software developer who made an enormous impact during his 26 short years on the planet. His campaigning work and direct action for freedom of information had led him into frequent conflict with the authorities, with the result that, at the time of his death, he faced 13 felony charges for which he was due to stand trial within the coming months.

David Cameron’s official 'blue sky' thinker Steve Hilton

Cameron’s Mr Blue Sky: how we found out our own policies from the papers

On sabbatical in California, Steve Hilton reveals ‘horror’ at how No 10 really works

This week's wackiest stories from the web: Stupid evolution and the first burger in space

If you have sex in public, but no one is watching, is it still obscene? Plus bones of ancient giant discovered and that regrettable Romney face tattoo

Brain imaging, such as this pictured at the Leibniz Institute for Neurobiology, is proving vital for understanding how the mind works

Identifying the brain's own facial recognition system

The ability to recognize faces is so important in humans that the brain appears to have an area solely devoted to the task: the fusiform gyrus.

The iPhone: Can't live without it

One teenager faces the ultimate challenge: A week without her iPhone

I just spent a week without one of the most important things in my life. It's something that I never go anywhere without, that I talk to when I'm lonely, that I stare at for hours upon end, day after day. It's there for me when my friends are not. It never argues with me or makes me feel bad about myself. I love it dearly and I can make it tell me that it loves me, too: My iPhone.

Awe therapy could 'improve our mental health and make us nicer'

A jaw-dropping moment really can make time appear to stand still - or at least slow down, new research suggests.

Stephen Hawking's thoughts... unredacted and unedited

A man like Stephen Hawking, renowned for his complex thinking, might be happy to have scientists read his brainwaves. The Cambridge professor, who suffers from motor neurone disease and is losing his ability to communicate via computer, is working with scientists hoping to read his brain.

Tests on fake retina 'encouraging'

Tests on a device that could restore sight to patients suffering from a common cause of blindness have produced "encouraging" results.

Andrew Luck is one of the names to watch at the NFL draft

American Football: Do believe the hype! NFL draft is the craziest show in town

It is fantasy football come true. Thirty-two teams picking future gridiron superstars live on prime-time television. What's not to like?

Cameron is a touch-screen Tory and totally techno -no surprise he has his own app

What's on Dave's dashboard?

David Cameron now has a special app to run the country. But what else is on his iPad? John Rentoul sneaks an iPeek

News
Mickey Rourke celebrates his victory against opponent Elliot Seymour
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Gordon and Tana Ramsay arrive at the High Court, London
newsTV chef gives evidence against his father-in-law in court case
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Actor Burt Reynolds last year
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Johnny Handle, Northumberland, Ted Relph, President of Lakeland Dialect Society, and Sid Calderbank, Lancashire, founder of the National Dialect Day
newsMeet the enthusiasts determined to stop them dying out
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The data shows that the number of “unlawfully” large infant classes has doubled in the last 12 months alone
i100Mike Stuchbery, a teacher in Great Yarmouth, said he received abuse
Arts and Entertainment
The starship in Star Wars: The Force Awakens
filmsThe first glimpse of JJ Abrams' new film has been released online
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Rio Ferdinand returns for QPR
sportRio Ferdinand returns from his three-game suspension today
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The Speaker of the House will takes his turn as guest editor of the Today programme
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Homeless Veterans Christmas Appeal: ‘We give them hope. They come to us when no one else can help’

Christmas Appeal

Meet the charity giving homeless veterans hope – and who they turn to when no one else can help
Should doctors and patients learn to plan humane, happier endings rather than trying to prolong life?

Is it always right to try to prolong life?

Most of us would prefer to die in our own beds, with our families beside us. But, as a GP, Margaret McCartney sees too many end their days in a medicalised battle
Thomas Cook's outgoing boss Harriet Green got by on four hours sleep a night - is that what it takes for women to get to the top?

What does it take for women to get to the top?

Thomas Cook's outgoing boss Harriet Green got by on four hours sleep a night and told women they had to do more if they wanted to get on
Christmas jumper craze: Inside the UK factory behind this year's multicultural must-have

Knitting pretty: British Christmas Jumpers

Simmy Richman visits Jack Masters, the company behind this year's multicultural must-have
French chefs have launched a campaign to end violence in kitchens - should British restaurants follow suit?

French chefs campaign against bullying

A group of top chefs signed a manifesto against violence in kitchens following the sacking of a chef at a Paris restaurant for scalding his kitchen assistant with a white-hot spoon
Radio 4 to broadcast 10-hour War and Peace on New Year's Day as Controller warns of cuts

Just what you need on a New Year hangover...

Radio 4 to broadcast 10-hour adaptation of War and Peace on first day of 2015
Cuba set to stage its first US musical in 50 years

Cuba to stage first US musical in 50 years

Claire Allfree finds out if the new production of Rent will hit the right note in Havana
Christmas 2014: 10 best educational toys

Learn and play: 10 best educational toys

Of course you want them to have fun, but even better if they can learn at the same time
Paul Scholes column: I like Brendan Rodgers as a manager but Liverpool seem to be going backwards not forwards this season

Paul Scholes column

I like Brendan Rodgers as a manager but Liverpool seem to be going backwards not forwards this season
Lewis Moody column: Stuart Lancaster has made all the right calls – now England must deliver

Lewis Moody: Lancaster has made all the right calls – now England must deliver

So what must the red-rose do differently? They have to take the points on offer 
Cameron, Miliband and Clegg join forces for Homeless Veterans campaign

Cameron, Miliband and Clegg join forces for Homeless Veterans campaign

It's in all our interests to look after servicemen and women who fall on hard times, say party leaders
Millionaire Sol Campbell wades into wealthy backlash against Labour's mansion tax

Sol Campbell cries foul at Labour's mansion tax

The former England defender joins Myleene Klass, Griff Rhys Jones and Melvyn Bragg in criticising proposals
Nicolas Sarkozy returns: The ex-President is preparing to fight for the leadership of France's main opposition party – but will he win big enough?

Sarkozy returns

The ex-President is preparing to fight for the leadership of France's main opposition party – but will he win big enough?
Is the criticism of Ed Miliband a coded form of anti-Semitism?

Is the criticism of Miliband anti-Semitic?

Attacks on the Labour leader have coalesced around a sense that he is different, weird, a man apart. But is the criticism more sinister?
Ouija boards are the must-have gift this Christmas, fuelled by a schlock horror film

Ouija boards are the must-have festive gift

Simon Usborne explores the appeal - and mysteries - of a century-old parlour game