Sport Peyton Manning broke Tom Brady's record for touchdown passes in a season

Devastated by injury and dumped by his beloved team, one of the NFL’s all-time great quarterbacks is back in business and breaking records

The Prime Minister's most influential adviser, Steve Hilton (pictured), has announced his departure from Downing Street

Steve Hilton's next Big Idea: Swap Downing Street for time out in California

He is credited as the architect of the Big Society and once suggested the abolition of paid maternity leave. Now Steve Hilton, David Cameron's most influential adviser, has pulled off one last surprise: unexpectedly announcing his departure from Downing Street for an unpaid academic job in California.

Conservative Party strategist Steve Hilton arrives in Downing Street on his bike earlier this month

Strategy guru Steve Hilton to take sabbatical

David Cameron's strategy guru Steve Hilton is quitting Downing Street for a year to take an academic position in the United States, Number 10 said.

A dead whitetip reef shark caught accidentally in a fishing net

Mobile marine reserves may end slaughter of endangered sea life

The indiscriminate slaughter of vast numbers of turtles, sharks, albatrosses and other endangered marine animals that get unintentionally caught by fishermen as “by-catch” could be prevented by a radical proposal of mobile marine reserves, scientists said yesterday.

Joy for San Francisco's Alex Smith as he scores a fourth-quarter touchdown against New Orleans Saints

American Football: Alex Smith - 'The Comeback Kid' goes from villain to hero in San Francisco

Much-maligned quarterback can guide the 49ers into an unlikely Super Bowl

Peter York: The secret and changing life of the private members' club

A chap banned for wearing a tie? Joanna Lumley at the Garrick? What <u>is</u> going on

Undisturbed night's sleep needed for good memory

A continuous night's uninterrupted sleep may be the essential requirement for a good memory, according to a study carried out on laboratory mice. The animals failed to remember things after being repeatedly disturbed while they dozed. The research is more subtle than it first appears because the researchers did not just investigate disturbed sleep, which can cause memory loss through stress, but also the length of time the mice engaged in deep sleep, when memories are believed to be consolidated by the resting brain.

Hope for millions of Alzheimer's sufferers as scientists make brain cells from human skin

Skin cells from a 30-year-old woman have been turned directly into mature nerve cells similar to those found in the brain using a procedure that promises to revolutionise the emerging field of regenerative medicine.

The <i>IoS</i> Happy List quiz 2011

Happiness is... puzzling over some daft questions in your favourite newspaper (answers at bottom of page)

Genetic breakthrough may pave way to new heart and stroke tests

Scientists have found the largest number of genes associated with an increased risk of developing heart disease in a study that helps to pave the way towards the day when doctors may be able to offer genetic tests that can identify people most at risk of heart attacks and strokes.

The Language Wars: a history of proper English, By Henry Hitchings

Wordsmith who's on the winning side

Larry Page: A very private poster boy

He will never make a showman. But as Google's co-founder steps up to be its CEO, can he display the business nous to match his genius as an inventor?

Employers discriminate against Muslims, study finds

Muslims face "massive discrimination" when applying for jobs, according to the first scientifically validated study of anti-Muslim bias among employers in France.

I'm no friend of Facebook film, says Zuckerberg

It's the movie everyone has been talking about, with the word Oscar regularly tripping from the lips of critics. But one voice has been notably absent from the discussion of The Social Network until now.

Consuming Issues: Hey big spender, it's all down to your genes

If you love chocolate, like me, you may be able to blame something other than considerable greed if you no longer fit into your jeans: your genes. Research is shedding light on the reasons we sometimes like things, or engage in risky behaviour.

New technique promises to take the lottery out of IVF

Thousands of infertile couples who repeatedly undergo IVF treatment in the hope of having a baby could soon benefit from a scientific breakthrough that promises a radical increase in the chances of a successful pregnancy.

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Day In a Page

Burgundy, the River Rhone & Provence – MS Swiss Corona - seven nights from £999pp
Lake Maggiore, Orta and the Matterhorn – seven nights from £899pp
Sicily – seven nights from £939pp
Pompeii, Capri and the Bay of Naples - seven nights from £799pp
Istanbul Ephesus & Troy – six nights from £859pp
Mary Rose – two nights from £319pp
Save the tiger: The day America’s love of backyard tigers led to a horrific bloodbath

The day America’s love of backyard tigers led to a horrific bloodbath

With only six per cent of the US population of these amazing big cats held in zoos, the Zanesville incident in 2011 was inevitable
Samuel Beckett's biographer reveals secrets of the writer's time as a French Resistance spy

How Samuel Beckett became a French Resistance spy

As this year's Samuel Beckett festival opens in Enniskillen, James Knowlson, recalls how the Irish writer risked his life for liberty and narrowly escaped capture by the Gestapo
We will remember them: relatives still honour those who fought in the Great War

We will remember them

Relatives still honour those who fought in the Great War
Star Wars Episode VII is being shot on film - and now Kodak is launching a last-ditch bid to keep celluloid alive

Kodak's last-ditch bid to keep celluloid alive

Director J J Abrams and a few digital refuseniks shoot movies on film. Simon Usborne wonders what the fuss is about
Once stilted and melodramatic, Hollywood is giving acting in video games a makeover

Acting in video games gets a makeover

David Crookes meets two of the genre's most popular voices
Could our smartphones soon be diagnosing diseases via Health Kit and Google Fit?

Could smartphones soon be diagnosing diseases?

Health Kit and Google Fit have been described as "the beginning of a health revolution"
Ryanair has turned on the 'charm offensive' but can we learn to love the cut-price carrier again?

Can we learn to love Ryanair again?

Four recent travellers give their verdicts on the carrier's improved customer service
Billionaire founder of Spanx launches range of jeans that offers

Spanx launches range of jeans

The jeans come in two styles, multiple cuts and three washes and will go on sale in the UK in October
10 best over-ear headphones

Aural pleasure: 10 best over-ear headphones

Listen to your favourite tracks with this selection, offering everything from lambskin earmuffs to stainless steel
Commonwealth Games 2014: David Millar ready to serve up gold for his beloved Scotland in the end

Commonwealth Games

David Millar ready to serve up gold for his beloved Scotland in the end
UCI Mountain Bike World Cup 2014: Downhill all the way to the top for the Atherton siblings

UCI Mountain Bike World Cup

Downhill all the way to the top for the Atherton siblings
Save the tiger: The animals bred for bones on China’s tiger farms

The animals bred for bones on China’s tiger farms

The big cats kept in captivity to perform for paying audiences and then, when dead, their bodies used to fortify wine
A former custard factory, a Midlands bog and a Leeds cemetery all included in top 50 hidden spots in the UK

A former custard factory, a Midlands bog and a Leeds cemetery

Introducing the top 50 hidden spots in Britain
Ebola epidemic: Plagued by fear

Ebola epidemic: Plagued by fear

How a disease that has claimed fewer than 2,000 victims in its history has earned a place in the darkest corner of the public's imagination
Chris Pratt: From 'Parks and Recreation' to 'Guardians of the Galaxy'

From 'Parks and Recreation' to 'Guardians of the Galaxy'

He was homeless in Hawaii when he got his big break. Now the comic actor Chris Pratt is Hollywood's new favourite action star