Sport Peyton Manning broke Tom Brady's record for touchdown passes in a season

Devastated by injury and dumped by his beloved team, one of the NFL’s all-time great quarterbacks is back in business and breaking records

The Prime Minister's most influential adviser, Steve Hilton (pictured), has announced his departure from Downing Street

Steve Hilton's next Big Idea: Swap Downing Street for time out in California

He is credited as the architect of the Big Society and once suggested the abolition of paid maternity leave. Now Steve Hilton, David Cameron's most influential adviser, has pulled off one last surprise: unexpectedly announcing his departure from Downing Street for an unpaid academic job in California.

Conservative Party strategist Steve Hilton arrives in Downing Street on his bike earlier this month

Strategy guru Steve Hilton to take sabbatical

David Cameron's strategy guru Steve Hilton is quitting Downing Street for a year to take an academic position in the United States, Number 10 said.

A dead whitetip reef shark caught accidentally in a fishing net

Mobile marine reserves may end slaughter of endangered sea life

The indiscriminate slaughter of vast numbers of turtles, sharks, albatrosses and other endangered marine animals that get unintentionally caught by fishermen as “by-catch” could be prevented by a radical proposal of mobile marine reserves, scientists said yesterday.

Joy for San Francisco's Alex Smith as he scores a fourth-quarter touchdown against New Orleans Saints

American Football: Alex Smith - 'The Comeback Kid' goes from villain to hero in San Francisco

Much-maligned quarterback can guide the 49ers into an unlikely Super Bowl

Peter York: The secret and changing life of the private members' club

A chap banned for wearing a tie? Joanna Lumley at the Garrick? What <u>is</u> going on

Undisturbed night's sleep needed for good memory

A continuous night's uninterrupted sleep may be the essential requirement for a good memory, according to a study carried out on laboratory mice. The animals failed to remember things after being repeatedly disturbed while they dozed. The research is more subtle than it first appears because the researchers did not just investigate disturbed sleep, which can cause memory loss through stress, but also the length of time the mice engaged in deep sleep, when memories are believed to be consolidated by the resting brain.

Hope for millions of Alzheimer's sufferers as scientists make brain cells from human skin

Skin cells from a 30-year-old woman have been turned directly into mature nerve cells similar to those found in the brain using a procedure that promises to revolutionise the emerging field of regenerative medicine.

The <i>IoS</i> Happy List quiz 2011

Happiness is... puzzling over some daft questions in your favourite newspaper (answers at bottom of page)

Genetic breakthrough may pave way to new heart and stroke tests

Scientists have found the largest number of genes associated with an increased risk of developing heart disease in a study that helps to pave the way towards the day when doctors may be able to offer genetic tests that can identify people most at risk of heart attacks and strokes.

The Language Wars: a history of proper English, By Henry Hitchings

Wordsmith who's on the winning side

Larry Page: A very private poster boy

He will never make a showman. But as Google's co-founder steps up to be its CEO, can he display the business nous to match his genius as an inventor?

Employers discriminate against Muslims, study finds

Muslims face "massive discrimination" when applying for jobs, according to the first scientifically validated study of anti-Muslim bias among employers in France.

I'm no friend of Facebook film, says Zuckerberg

It's the movie everyone has been talking about, with the word Oscar regularly tripping from the lips of critics. But one voice has been notably absent from the discussion of The Social Network until now.

Consuming Issues: Hey big spender, it's all down to your genes

If you love chocolate, like me, you may be able to blame something other than considerable greed if you no longer fit into your jeans: your genes. Research is shedding light on the reasons we sometimes like things, or engage in risky behaviour.

New technique promises to take the lottery out of IVF

Thousands of infertile couples who repeatedly undergo IVF treatment in the hope of having a baby could soon benefit from a scientific breakthrough that promises a radical increase in the chances of a successful pregnancy.

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All this talk of an ‘apocalyptic’ threat is simply childish

Robert Fisk: All this talk of an ‘apocalyptic’ threat is simply childish

Chuck Hagel and Martin Dempsey were pure Hollywood. They only needed Tom Cruise
Mafia Dons: is the Camorra in control of the Granite City?

Mafia Dons: is the Camorra in control of the Granite City?

So claims an EU report which points to the Italian Mob’s alleged grip on everything from public works to property
Emmys look set to overhaul the Oscars as Hollywood’s prize draw

Emmys look set to overhaul the Oscars as Hollywood’s prize draw

Once the poor relation, the awards show now has the top stars and boasts the best drama
What happens to African migrants once they land in Italy during the summer?

What happens to migrants once they land in Italy?

Memphis Barker follows their trail through southern Europe
French connection: After 1,300 years, there’s a bridge to Mont Saint-Michel

French connection: After 1,300 years, there’s a bridge to Mont Saint-Michel

The ugly causeway is being dismantled, an elegant connection erected in its place. So everyone’s happy, right?
Frank Mugisha: Uganda's most outspoken gay rights activist on changing people's attitudes, coming out, and the threat of being attacked

Frank Mugisha: 'Coming out was a gradual process '

Uganda's most outspoken gay rights activist on changing people's attitudes, coming out, and the threat of being attacked
Radio 1 to hire 'YouTube-famous' vloggers to broadcast online

Radio 1’s new top ten

The ‘vloggers’ signed up to find twentysomething audience
David Abraham: Big ideas for the small screen

David Abraham: Big ideas for the small screen

A blistering attack on US influence on British television has lifted the savvy head of Channel 4 out of the shadows
Florence Knight's perfect picnic: Make the most of summer's last Bank Holiday weekend

Florence Knight's perfect picnic

Polpetto's head chef shares her favourite recipes from Iced Earl Grey tea to baked peaches, mascarpone & brown sugar meringues...
Horst P Horst: The fashion photography genius who inspired Madonna comes to the V&A

Horst P Horst comes to the V&A

The London's museum has delved into its archives to stage a far-reaching retrospective celebrating the photographer's six decades of creativity
Mark Hix recipes: Try our chef's summery soups for a real seasonal refresher

Mark Hix's summery soups

Soup isn’t just about comforting broths and steaming hot bowls...
Tim Sherwood column: 'It started as a three-horse race but turned into the Grand National'

Tim Sherwood column

I would have taken the Crystal Palace job if I’d been offered it soon after my interview... but the whole process dragged on so I had to pull out
Eden Hazard: Young, gifted... not yet perfect

Eden Hazard: Young, gifted... not yet perfect

Eden Hazard admits he is still below the level of Ronaldo and Messi but, after a breakthrough season, is ready to thrill Chelsea’s fans
Tim Howard: I’m an old dog. I don’t get too excited

Tim Howard: I’m an old dog. I don’t get too excited

The Everton and US goalkeeper was such a star at the World Cup that the President phoned to congratulate him... not that he knows what the fuss is all about
Match of the Day at 50: Show reminds us that even the most revered BBC institution may have a finite lifespan – thanks to the opposition

Tom Peck on Match of the Day at 50

The show reminds us that even the most revered BBC institution may have a finite lifespan – thanks to the opposition