Sport Peyton Manning broke Tom Brady's record for touchdown passes in a season

Devastated by injury and dumped by his beloved team, one of the NFL’s all-time great quarterbacks is back in business and breaking records

The Prime Minister's most influential adviser, Steve Hilton (pictured), has announced his departure from Downing Street

Steve Hilton's next Big Idea: Swap Downing Street for time out in California

He is credited as the architect of the Big Society and once suggested the abolition of paid maternity leave. Now Steve Hilton, David Cameron's most influential adviser, has pulled off one last surprise: unexpectedly announcing his departure from Downing Street for an unpaid academic job in California.

Conservative Party strategist Steve Hilton arrives in Downing Street on his bike earlier this month

Strategy guru Steve Hilton to take sabbatical

David Cameron's strategy guru Steve Hilton is quitting Downing Street for a year to take an academic position in the United States, Number 10 said.

A dead whitetip reef shark caught accidentally in a fishing net

Mobile marine reserves may end slaughter of endangered sea life

The indiscriminate slaughter of vast numbers of turtles, sharks, albatrosses and other endangered marine animals that get unintentionally caught by fishermen as “by-catch” could be prevented by a radical proposal of mobile marine reserves, scientists said yesterday.

Joy for San Francisco's Alex Smith as he scores a fourth-quarter touchdown against New Orleans Saints

American Football: Alex Smith - 'The Comeback Kid' goes from villain to hero in San Francisco

Much-maligned quarterback can guide the 49ers into an unlikely Super Bowl

Peter York: The secret and changing life of the private members' club

A chap banned for wearing a tie? Joanna Lumley at the Garrick? What <u>is</u> going on

Undisturbed night's sleep needed for good memory

A continuous night's uninterrupted sleep may be the essential requirement for a good memory, according to a study carried out on laboratory mice. The animals failed to remember things after being repeatedly disturbed while they dozed. The research is more subtle than it first appears because the researchers did not just investigate disturbed sleep, which can cause memory loss through stress, but also the length of time the mice engaged in deep sleep, when memories are believed to be consolidated by the resting brain.

Hope for millions of Alzheimer's sufferers as scientists make brain cells from human skin

Skin cells from a 30-year-old woman have been turned directly into mature nerve cells similar to those found in the brain using a procedure that promises to revolutionise the emerging field of regenerative medicine.

The <i>IoS</i> Happy List quiz 2011

Happiness is... puzzling over some daft questions in your favourite newspaper (answers at bottom of page)

Genetic breakthrough may pave way to new heart and stroke tests

Scientists have found the largest number of genes associated with an increased risk of developing heart disease in a study that helps to pave the way towards the day when doctors may be able to offer genetic tests that can identify people most at risk of heart attacks and strokes.

The Language Wars: a history of proper English, By Henry Hitchings

Wordsmith who's on the winning side

Larry Page: A very private poster boy

He will never make a showman. But as Google's co-founder steps up to be its CEO, can he display the business nous to match his genius as an inventor?

Employers discriminate against Muslims, study finds

Muslims face "massive discrimination" when applying for jobs, according to the first scientifically validated study of anti-Muslim bias among employers in France.

I'm no friend of Facebook film, says Zuckerberg

It's the movie everyone has been talking about, with the word Oscar regularly tripping from the lips of critics. But one voice has been notably absent from the discussion of The Social Network until now.

Consuming Issues: Hey big spender, it's all down to your genes

If you love chocolate, like me, you may be able to blame something other than considerable greed if you no longer fit into your jeans: your genes. Research is shedding light on the reasons we sometimes like things, or engage in risky behaviour.

New technique promises to take the lottery out of IVF

Thousands of infertile couples who repeatedly undergo IVF treatment in the hope of having a baby could soon benefit from a scientific breakthrough that promises a radical increase in the chances of a successful pregnancy.

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Rio Ferdinand, Alan Shearer, Alan Hansen and Gary Lineker during Hansen's final broadcast
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Brendan O'Carroll has brought out his female alter-ego Agnes Brown for Mrs Brown's Boys D'Movie
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Ian Thorpe has thanked his supporters after the athlete said in an interview that he is gay
people
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Eminem's daughter Hailie has graduated from high school
music
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Original Netflix series such as Orange Is The New Black are to benefit from a 'substantial' increase in investment
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Swimsuit, £245, by Agent Provocateur
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Diving in at the deep end is no excuse for shirking the style stakes

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Iraq crisis: How Saudi Arabia helped Isis take over the north of the country

How Saudi Arabia helped Isis take over northern Iraq

A speech by an ex-MI6 boss hints at a plan going back over a decade. In some areas, being Shia is akin to being a Jew in Nazi Germany, says Patrick Cockburn
The evolution of Andy Serkis: First Gollum, then King Kong - now the actor is swinging through the trees in Dawn of the Planet of the Apes

The evolution of Andy Serkis

First Gollum, then King Kong - now the actor is swinging through the trees in Dawn of the Planet of the Apes
You thought 'Benefits Street' was controversial: Follow-up documentary 'Immigrant Street' has got locals worried

You thought 'Benefits Street' was controversial...

Follow-up documentary 'Immigrant Street' has got locals worried
Refugee children from Central America let down by Washington's high ideals

Refugee children let down by Washington's high ideals

Democrats and Republicans refuse to set aside their differences to cope with the influx of desperate Central Americas, says Rupert Cornwell
Children's books are too white, says Laureate

Children's books are too white, says Laureate

Malorie Blackman appeals for a better ethnic mix of authors and characters and the illustrator Quentin Blake comes to the rescue
Blackest is the new black: Scientists have developed a material so dark that you can't see it...

Blackest is the new black

Scientists have developed a material so dark that you can't see it...
Matthew Barzun: America's diplomatic dude

Matthew Barzun: America's diplomatic dude

The US Ambassador to London holds 'jeans and beer' gigs at his official residence – it's all part of the job, he tells Chris Green
Meet the Quantified Selfers: From heart rates to happiness, there is little this fast-growing, self-tracking community won't monitor

Meet the 'Quantified Selfers'

From heart rates to happiness, there is little this fast-growing, self-tracking community won't monitor
Madani Younis: Five-star reviews are just the opening act for British theatre's first non-white artistic director

Five-star reviews are just the opening act for British theatre's first non-white artistic director

Madani Younis wants the neighbourhood to follow his work as closely as his audiences do
Mrs Brown and her boys: are they having a laugh?

Mrs Brown and her boys: are they having a laugh?

When it comes to national stereotyping, the Irish – among others – know it can pay to play up to outsiders' expectations, says DJ Taylor
Gavin Maxwell's bitter legacy: Was the otter man the wildlife champion he appeared to be?

Otter man Gavin Maxwell's bitter legacy

The aristocrat's eccentric devotion to his pets inspired a generation. But our greatest living nature writer believes his legacy has been quite toxic
Joanna Rowsell: The World Champion cyclist on breaking her collarbone, shattering her teeth - and dealing with alopecia

Joanna Rowsell: 'I wear my wig to look normal'

The World Champion cyclist on breaking her collarbone, shattering her teeth - and dealing with alopecia
Bill Granger recipes: Our chef gives raw ingredients a lift with his quick marinades

Bill Granger's quick and delicious marinades

Our chef's marinades are great for weekend barbecuing, but are also a delicious way of injecting flavour into, and breaking the monotony of, weekday meals
Germany vs Argentina World Cup 2014 preview: Why Brazilians don't love their neighbours Argentina any more

Anyone but Argentina – why Brazilians don’t love their neighbours any more

The hosts will be supporting Germany in today's World Cup final, reports Alex Bellos
The Open 2014: Time again to ask that major question - can Lee Westwood win at last?

The Open 2014

Time again to ask that major question - can Lee Westwood win at last?