Sport Peyton Manning broke Tom Brady's record for touchdown passes in a season

Devastated by injury and dumped by his beloved team, one of the NFL’s all-time great quarterbacks is back in business and breaking records

The Prime Minister's most influential adviser, Steve Hilton (pictured), has announced his departure from Downing Street

Steve Hilton's next Big Idea: Swap Downing Street for time out in California

He is credited as the architect of the Big Society and once suggested the abolition of paid maternity leave. Now Steve Hilton, David Cameron's most influential adviser, has pulled off one last surprise: unexpectedly announcing his departure from Downing Street for an unpaid academic job in California.

Conservative Party strategist Steve Hilton arrives in Downing Street on his bike earlier this month

Strategy guru Steve Hilton to take sabbatical

David Cameron's strategy guru Steve Hilton is quitting Downing Street for a year to take an academic position in the United States, Number 10 said.

A dead whitetip reef shark caught accidentally in a fishing net

Mobile marine reserves may end slaughter of endangered sea life

The indiscriminate slaughter of vast numbers of turtles, sharks, albatrosses and other endangered marine animals that get unintentionally caught by fishermen as “by-catch” could be prevented by a radical proposal of mobile marine reserves, scientists said yesterday.

Joy for San Francisco's Alex Smith as he scores a fourth-quarter touchdown against New Orleans Saints

American Football: Alex Smith - 'The Comeback Kid' goes from villain to hero in San Francisco

Much-maligned quarterback can guide the 49ers into an unlikely Super Bowl

Peter York: The secret and changing life of the private members' club

A chap banned for wearing a tie? Joanna Lumley at the Garrick? What <u>is</u> going on

Undisturbed night's sleep needed for good memory

A continuous night's uninterrupted sleep may be the essential requirement for a good memory, according to a study carried out on laboratory mice. The animals failed to remember things after being repeatedly disturbed while they dozed. The research is more subtle than it first appears because the researchers did not just investigate disturbed sleep, which can cause memory loss through stress, but also the length of time the mice engaged in deep sleep, when memories are believed to be consolidated by the resting brain.

Hope for millions of Alzheimer's sufferers as scientists make brain cells from human skin

Skin cells from a 30-year-old woman have been turned directly into mature nerve cells similar to those found in the brain using a procedure that promises to revolutionise the emerging field of regenerative medicine.

The <i>IoS</i> Happy List quiz 2011

Happiness is... puzzling over some daft questions in your favourite newspaper (answers at bottom of page)

Genetic breakthrough may pave way to new heart and stroke tests

Scientists have found the largest number of genes associated with an increased risk of developing heart disease in a study that helps to pave the way towards the day when doctors may be able to offer genetic tests that can identify people most at risk of heart attacks and strokes.

The Language Wars: a history of proper English, By Henry Hitchings

Wordsmith who's on the winning side

Larry Page: A very private poster boy

He will never make a showman. But as Google's co-founder steps up to be its CEO, can he display the business nous to match his genius as an inventor?

Employers discriminate against Muslims, study finds

Muslims face "massive discrimination" when applying for jobs, according to the first scientifically validated study of anti-Muslim bias among employers in France.

I'm no friend of Facebook film, says Zuckerberg

It's the movie everyone has been talking about, with the word Oscar regularly tripping from the lips of critics. But one voice has been notably absent from the discussion of The Social Network until now.

Consuming Issues: Hey big spender, it's all down to your genes

If you love chocolate, like me, you may be able to blame something other than considerable greed if you no longer fit into your jeans: your genes. Research is shedding light on the reasons we sometimes like things, or engage in risky behaviour.

New technique promises to take the lottery out of IVF

Thousands of infertile couples who repeatedly undergo IVF treatment in the hope of having a baby could soon benefit from a scientific breakthrough that promises a radical increase in the chances of a successful pregnancy.

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Prices correct as of 17 April 2015
Revealed: Why Mohammed Emwazi chose the 'safe option' of fighting for Isis, rather than following his friends to al-Shabaab in Somalia

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His friends were betrayed and killed by al-Shabaab
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Hillary Clinton's outfits will be as important as her policies in her presidential bid

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Who's monitoring the outsourced NHS services?

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Zac Goldsmith: 'I'll trigger a by-election over Heathrow'

Zac Goldsmith: 'I'll trigger a by-election over Heathrow'

The Tory MP said he did not want to stand again unless his party's manifesto ruled out a third runway. But he's doing so. Watch this space
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From Iraq to Libya and Syria: The wars that come back to haunt us

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