Sport Peyton Manning broke Tom Brady's record for touchdown passes in a season

Devastated by injury and dumped by his beloved team, one of the NFL’s all-time great quarterbacks is back in business and breaking records

Paperbacks: Solzhenitsyn cavorts at Studio 54

20th Century Dreams

Blueprint for creating artificial life is discovered Minimum genes to support living organisms found

A SIGNIFICANT milestone in the attempt to synthesise "artificial" life in a test tube hasbeen reached with the discovery of the minimal number of genes needed to support a living organism.

Network: The spies can't cope with information overload

THE CRESCENT moon hangs high in the eastern Silicon Valley sky: Venus shines bright, unblinking just below. The air is chill as three figures step out into the pre-dawn gloom and jog up Sand Hill Road, the Wall Street of hi-tech. Cassie the dog is, as usual, in the lead, her blinking LED collar marking the way. Spouse Linda jogs a few steps behind while I'm in my customary middle position. It's 6am.

Obituary: George V. Higgins

IT IS unquestionably unfair to dub any writer a one-book man, especially when he's published well over 20. Nevertheless in the case of George V. Higgins the fact has to be faced. He wrote superbly dialogued, complexly plotted, richly characterised novels - yet all just a slight variation on the same basic riff. And, as the years went by and the books stacked up, the similarities began to stand out, hardly helped by their author's reliance, more and more, on pure dialogue, to the point where narrative - scene descriptions, back-story, the intricate social hinterland against which the novels' events were played out - virtually disappeared. Until, in essence, all that remained was "two guys gabbing at each other" - or even one guy soliloquising for paragraph after paragraph, page after interminable page.

Film studies: She's classy. She's presidential. She's Reese

The unlikely names run together in chattery abandon - Parker Posey, Heather Graham, Charlize Theron, Angelina Jolie, Cameron Diaz, Alicia Silverstone, Drew Barrymore, Liv Tyler, Neve Campbell, Denise Richards, and so on. Los Angeles, crowded out with drop-dead kids, seems to require some Warholian likelihood that every one will get her chance in a picture. It's a sort of snapshot souvenir - proof that they were here. What's the risk, the system asks: you get new meat on the screen, a 10 for ravishing desirability, and the girl walks off with a few hundred grand and the experience. It's a start in life. Where's the harm, when the kids are wide-eyed know-nothings with this one loony sophistication - they seem to possess every acting pose gathered in a century of movies.

Science: How fiction can help science tell the truth

EUROPEAN LITERATURE and plays have, with rare exceptions, not been kind to science; they certainly have made no contribution to science. So it comes as a surprise to find, in a recent issue of the prestigious American journal Science, that several pages of a play, An Immaculate Misconception, are reproduced.

Letter: In Hoover's honour

Sir: If Chris Gulker would pause for a closer look at Hoover Tower, mid-jog, in his circuit along Sand Hill Road and through the Stanford University campus, he would discover that Stanford's distinctive landmark was named not "for the cross-dressing former head of the FBI", but for the former US President Herbert Hoover ("Outraged? A brisk jog is just the ticket", 16 August).

Network: Outraged? A brisk jog is just the ticket

IF JOGGING on Silicon Valley's Sand Hill Road is inspirational, then I'm one inspired fella. My wife, Linda, Cassie the dog and I jog here six mornings a week, alternating among three routes to keep it interesting. Any long-time jogger knows about runner's reverie. This is a trance-like state that overtakes the head as the feet, on autopilot, follow a well-worn trail.

US fall in crime `due to abortion'

AS THE crime rate has fallen in America, so politicians, intellectuals and everyone have puzzled over the reasons. Now two American academics have produced a theory that will infuriate virtually everyone: the fall in crime is the result of legalising abortion in the 1970s.

How we met: Ken Kesey & Ken Babbs

Ken Kesey, 64, was born in Oregon, and studied at Stanford University. Aged 23, he volunteered to take part in CIA-funded LSD experiments. His work in a psychiatric hospital helped inspire his book `One Flew Over the Cuckoo's Nest' (1962). In 1964 he and a group of friends calling themselves the Merry Pranksters toured America in a psychedelically painted bus which they packed with acid

Tennis: Rubin makes Davenport sweat

THE WIMBLEDON champion and world No 1, Lindsay Davenport, was pushed all the way before beating Chanda Rubin 6-3, 6-7, 6-3 at the Bank of the West Classic in Stanford University in California.

Tennis: Henman rues his loss to Raoux

TENNIS

Ex-commando toughed out his early poll errors

THE ONE fact about Ehud Barak that is likely to win him most votes in today's election is that he is not Benjamin Netanyahu. It may be enough to make him prime minister.

Women more at risk from lung cancer

WOMEN SMOKERS are more at risk from lung cancer because they are genetically more susceptible to tobacco carcinogens, according to new research.
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Syria crisis: Celebrities call on David Cameron to take more refugees as one young mother tells of torture by Assad regime

Celebrities call on David Cameron to take more Syrian refugees

One young mother tells of torture by Assad regime
The enemy within: People who hear voices in their heads are being encouraged to talk back – with promising results

The enemy within

People who hear voices in their heads are being encouraged to talk back
'In Auschwitz you got used to anything'

'In Auschwitz you got used to anything'

Survivors of the Nazi concentration camp remember its horror, 70 years on
Autumn/winter menswear 2015: The uniforms that make up modern life come to the fore

Autumn/winter menswear 2015

The uniforms that make up modern life come to the fore
'I'm gay, and plan to fight military homophobia'

'I'm gay, and plan to fight military homophobia'

Army general planning to come out
Iraq invasion 2003: The bloody warnings six wise men gave to Tony Blair as he prepared to launch poorly planned campaign

What the six wise men told Tony Blair

Months before the invasion of Iraq in 2003, experts sought to warn the PM about his plans. Here, four of them recall that day
25 years of The Independent on Sunday: The stories, the writers and the changes over the last quarter of a century

25 years of The Independent on Sunday

The stories, the writers and the changes over the last quarter of a century
Homeless Veterans appeal: 'Really caring is a dangerous emotion in this kind of work'

Homeless Veterans appeal

As head of The Soldiers' Charity, Martin Rutledge has to temper compassion with realism. He tells Chris Green how his Army career prepared him
Wu-Tang Clan and The Sexual Objects offer fans a chance to own the only copies of their latest albums

Smash hit go under the hammer

It's nice to pick up a new record once in a while, but the purchasers of two latest releases can go a step further - by buying the only copy
Geeks who rocked the world: Documentary looks back at origins of the computer-games industry

The geeks who rocked the world

A new documentary looks back at origins of the computer-games industry
Belle & Sebastian interview: Stuart Murdoch reveals how the band is taking a new direction

Belle & Sebastian is taking a new direction

Twenty years ago, Belle & Sebastian was a fey indie band from Glasgow. It still is – except today, as prime mover Stuart Murdoch admits, it has a global cult following, from Hollywood to South Korea
America: Land of the free, home of the political dynasty

America: Land of the free, home of the political dynasty

These days in the US things are pretty much stuck where they are, both in politics and society at large, says Rupert Cornwell
A graphic history of US civil rights – in comic book form

A graphic history of US civil rights – in comic book form

A veteran of the Fifties campaigns is inspiring a new generation of activists
Winston Churchill: the enigma of a British hero

Winston Churchill: the enigma of a British hero

A C Benson called him 'a horrid little fellow', George Orwell would have shot him, but what a giant he seems now, says DJ Taylor
Growing mussels: Precious freshwater shellfish are thriving in a unique green project

Growing mussels

Precious freshwater shellfish are thriving in a unique green project