Sport Peyton Manning broke Tom Brady's record for touchdown passes in a season

Devastated by injury and dumped by his beloved team, one of the NFL’s all-time great quarterbacks is back in business and breaking records

Paperbacks: Solzhenitsyn cavorts at Studio 54

20th Century Dreams

Blueprint for creating artificial life is discovered Minimum genes to support living organisms found

A SIGNIFICANT milestone in the attempt to synthesise "artificial" life in a test tube hasbeen reached with the discovery of the minimal number of genes needed to support a living organism.

Network: The spies can't cope with information overload

THE CRESCENT moon hangs high in the eastern Silicon Valley sky: Venus shines bright, unblinking just below. The air is chill as three figures step out into the pre-dawn gloom and jog up Sand Hill Road, the Wall Street of hi-tech. Cassie the dog is, as usual, in the lead, her blinking LED collar marking the way. Spouse Linda jogs a few steps behind while I'm in my customary middle position. It's 6am.

Obituary: George V. Higgins

IT IS unquestionably unfair to dub any writer a one-book man, especially when he's published well over 20. Nevertheless in the case of George V. Higgins the fact has to be faced. He wrote superbly dialogued, complexly plotted, richly characterised novels - yet all just a slight variation on the same basic riff. And, as the years went by and the books stacked up, the similarities began to stand out, hardly helped by their author's reliance, more and more, on pure dialogue, to the point where narrative - scene descriptions, back-story, the intricate social hinterland against which the novels' events were played out - virtually disappeared. Until, in essence, all that remained was "two guys gabbing at each other" - or even one guy soliloquising for paragraph after paragraph, page after interminable page.

Film studies: She's classy. She's presidential. She's Reese

The unlikely names run together in chattery abandon - Parker Posey, Heather Graham, Charlize Theron, Angelina Jolie, Cameron Diaz, Alicia Silverstone, Drew Barrymore, Liv Tyler, Neve Campbell, Denise Richards, and so on. Los Angeles, crowded out with drop-dead kids, seems to require some Warholian likelihood that every one will get her chance in a picture. It's a sort of snapshot souvenir - proof that they were here. What's the risk, the system asks: you get new meat on the screen, a 10 for ravishing desirability, and the girl walks off with a few hundred grand and the experience. It's a start in life. Where's the harm, when the kids are wide-eyed know-nothings with this one loony sophistication - they seem to possess every acting pose gathered in a century of movies.

Science: How fiction can help science tell the truth

EUROPEAN LITERATURE and plays have, with rare exceptions, not been kind to science; they certainly have made no contribution to science. So it comes as a surprise to find, in a recent issue of the prestigious American journal Science, that several pages of a play, An Immaculate Misconception, are reproduced.

Letter: In Hoover's honour

Sir: If Chris Gulker would pause for a closer look at Hoover Tower, mid-jog, in his circuit along Sand Hill Road and through the Stanford University campus, he would discover that Stanford's distinctive landmark was named not "for the cross-dressing former head of the FBI", but for the former US President Herbert Hoover ("Outraged? A brisk jog is just the ticket", 16 August).

Network: Outraged? A brisk jog is just the ticket

IF JOGGING on Silicon Valley's Sand Hill Road is inspirational, then I'm one inspired fella. My wife, Linda, Cassie the dog and I jog here six mornings a week, alternating among three routes to keep it interesting. Any long-time jogger knows about runner's reverie. This is a trance-like state that overtakes the head as the feet, on autopilot, follow a well-worn trail.

US fall in crime `due to abortion'

AS THE crime rate has fallen in America, so politicians, intellectuals and everyone have puzzled over the reasons. Now two American academics have produced a theory that will infuriate virtually everyone: the fall in crime is the result of legalising abortion in the 1970s.

How we met: Ken Kesey & Ken Babbs

Ken Kesey, 64, was born in Oregon, and studied at Stanford University. Aged 23, he volunteered to take part in CIA-funded LSD experiments. His work in a psychiatric hospital helped inspire his book `One Flew Over the Cuckoo's Nest' (1962). In 1964 he and a group of friends calling themselves the Merry Pranksters toured America in a psychedelically painted bus which they packed with acid

Tennis: Rubin makes Davenport sweat

THE WIMBLEDON champion and world No 1, Lindsay Davenport, was pushed all the way before beating Chanda Rubin 6-3, 6-7, 6-3 at the Bank of the West Classic in Stanford University in California.

Tennis: Henman rues his loss to Raoux

TENNIS

Ex-commando toughed out his early poll errors

THE ONE fact about Ehud Barak that is likely to win him most votes in today's election is that he is not Benjamin Netanyahu. It may be enough to make him prime minister.

Women more at risk from lung cancer

WOMEN SMOKERS are more at risk from lung cancer because they are genetically more susceptible to tobacco carcinogens, according to new research.
Life and Style
A monstrous idea? Body transplants might no longer be science fiction
Science An Italian neurosurgeon believes so - and it's not quite as implausible as it sounds, says Steve Connor
Sport
Demba Ba (right) celebrates after Besiktas win on penalties
footballThere was no happy return to the Ataturk Stadium, where the Reds famously won Champions League
Arts and Entertainment
Natural beauty: Aidan Turner stars in the new series of Poldark
arts + ents
News
Mia Freedman, editorial director of the Mamamia website, reads out a tweet she was sent.
arts + ents
News
people
Arts and Entertainment
The write stuff: masters of story-telling James Joyce, left, and Thomas Hardy
arts + ents...begging to differ, John Walsh can't even begin to number the ways
Sport
Jose Mourinho on Sky Sports
footballEXCLUSIVE COLUMN Paul Scholes: It was not a leg-breaking tackle, as the Chelsea manager had claimed
Career Services

Day In a Page

Independent Travel
Pompeii, Capri & the Bay of Naples
Seven Cities of Italy
Burgundy, the River Rhone & Provence
Prague, Budapest and Vienna
Lake Garda
3.	Provence 6 nights B&B by train from £599pp
Prices correct as of 20 February 2015
HIV pill: Scientists hail discovery of 'game-changer' that cuts the risk of infection among gay men by 86%

Scientists hail daily pill that protects against HIV infection

Breakthrough in battle against global scourge – but will the NHS pay for it?
How we must adjust our lifestyles to nature: Welcome to the 'Anthropocene', the human epoch

Time to play God

Welcome to the 'Anthropocene', the human epoch where we may need to redefine nature itself
MacGyver returns, but with a difference: Handyman hero of classic 1980s TV series to be recast as a woman

MacGyver returns, but with a difference

Handyman hero of classic 1980s TV series to be recast as a woman
Tunnel renaissance: Why cities are hiding roads down in the ground

Tunnel renaissance

Why cities are hiding roads underground
'Backstreet Boys - Show 'Em What You're Made Of': An affectionate look at five middle-aged men

Boys to men

The Backstreet Boys might be middle-aged, married and have dodgy knees, but a heartfelt documentary reveals they’re not going gently into pop’s good night
Crufts 2015: Should foreign dogs be allowed to compete?

Crufts 2015

Should foreign dogs be allowed to compete?
10 best projectors

How to make your home cinema more cinematic: 10 best projectors

Want to recreate the big-screen experience in your sitting room? IndyBest sizes up gadgets to form your film-watching
Manchester City 1 Barcelona 2 player ratings: Luis Suarez? Lionel Messi? Joe Hart? Who was the star man?

Manchester City vs Barcelona player ratings

Luis Suarez? Lionel Messi? Joe Hart? Who was the star man at the Etihad?
Arsenal vs Monaco: Monaco - the making of Gunners' manager Arsene Wenger

Monaco: the making of Wenger

Jack Pitt-Brooke speaks to former players and learns the Frenchman’s man-management has always been one of his best skills
Cricket World Cup 2015: Chris Gayle - the West Indies' enigma lives up to his reputation

Chris Gayle: The West Indies' enigma

Some said the game's eternal rebel was washed up. As ever, he proved he writes the scripts by producing a blistering World Cup innings
In Ukraine a dark world of hybrid warfare and murky loyalties prevails

In Ukraine a dark world of hybrid warfare

This war in the shadows has been going on since the fall of Mr Yanukovych
'Birdman' and 'Bullets Over Broadway': Homage or plagiarism?

Homage or plagiarism?

'Birdman' shares much DNA with Woody Allen's 'Bullets Over Broadway'
Broadchurch ends as damp squib not even David Tennant can revive

A damp squib not even David Tennant can revive

Broadchurch, Series 2 finale, review
A Koi carp breeding pond, wall-mounted iPads and a bathroom with a 'wellness' shower: inside the mansion of Germany's 'Bishop of Bling'

Inside the mansion of Germany's 'Bishop of Bling'

A Koi carp breeding pond, wall-mounted iPads and a bathroom with a 'wellness' shower