Asthma breakthrough may lead to improved treatment

Scientists have discovered a gene involved in the development of asthma, a finding that promises to lead to better treatment and understanding of the respiratory disorder.

A team of medical geneticists led by Professor William Cookson, of Oxford University, announced the discovery of an asthma gene at the weekend after six years of intensive investigation involving more than 20 doctors.

The gene appears to be involved in regulating white blood cells which produce the key antibody that plays a role in triggering the extreme allergies implicated in asthma and childhood eczema, a skin disorder.

"Finding the new gene adds a new dimension to understanding asthma and allergic diseases, but the understanding is still incomplete," Professor Cookson said.

There are about 10 genetic traits that are known to play a role in predisposing someone to asthma and about half of these genes have been identified.

The latest gene, called PhF11, is located on chromosome 13, which has been known for many years to contain a gene for asthma. Its discovery, published in the journal Nature Genetics, may lead to better classification of the disease and to new treatments, Professor Cookson said. "It is very likely that all the important genes will be found in the next three years. Even without knowing all the genes involved in asthma, our ideas about the causes of the disease are changing and we are seeing new ways to treat the illness," the professor said.

Asthma has been one of the fastest-growing disorders in Britain, affecting one in seven children. Worldwide, about 155 million people have been diagnosed with the respiratory disorder. Although environmental factors, such as house-dust mites, are linked with asthma, there is also a strong genetic component, with some people being innately more susceptible than others.

By studying the role of genes in asthma, scientists hope to understand the factors that trigger the disease and how to treat the symptoms at a more fundamental level.

Professor Cookson said that different variations of certain genes were usually associated with severe asthma in adults but added that the PhF11 gene might be involved in milder forms of asthma and eczema in children.

One possible goal for new forms of treatment could be to develop drugs that could turn off the genetic "switches" involved in the production of the immunoglobin E (IgE) antibody, which is heavily implicated in many allergic reactions, including asthmatic attacks. "The challenge of translating genetic findings into new treatments is, however, not trivial and will not be accomplished overnight," Professor Cookson said. "This type of genetic research is expensive and laborious and takes years of work."

When scientists first began to locate the genetic traits for asthma more than a decade ago, commentators suggested that their work would lead to a cure for asthma within five years, a prediction that has proved optimistic.

Donna Covey, representing the National Asthma Campaign, which funded the study with the Wellcome Trust, said that genetics was making an impact on the understanding of the respiratory disorder.

"We already know that developing asthma depends on the balance of genetic factors and environmental factors to which they are exposed," Ms Covey said.

News
Susan Sarandon described David Bowie as
peopleSusan Sarandon reveals more on her David Bowie romance
Sport
sportDidier Drogba returns to Chelsea on one-year deal
Arts and Entertainment
The Secret Cinema performance of Back to the Future has been cancelled again
film
News
people
PROMOTED VIDEO
Life and Style
ebookA wonderful selection of salads, starters and mains featuring venison, grouse and other game
Arts and Entertainment
Christian Grey cradles Ana in the Fifty Shades of Grey film
filmFifty Shades of Grey trailer provokes moral outrage in US
News
BBC broadcaster and presenter Evan Davis, who will be taking over from Jeremy Paxman on Newsnight
peopleForget Paxman - what will Evan Davis be like on Newsnight?
Sport
Louis van Gaal would have been impressed with Darren Fletcher’s performance against LA Galaxy during Manchester United’s 7-0 victory
football
Voices
The new dawn heralded by George Osborne has yet to rise
voicesJames Moore: As the Tories rub their hands together, the average voter will be asking why they're not getting a piece of the action
Sport
Dejan Lovren celebrates scoring for Southampton although the goal was later credited to Adam Lallana
sport
News
newsComedy club forced to apologise as maggots eating a dead pigeon fall out of air-conditioning
Arts and Entertainment
Jo Brand says she's mellowed a lot
tvJo Brand says shows encourage people to laugh at the vulnerable
Life and Style
People may feel that they're procrastinating by watching TV in the evening
life
Sport
Rhys Williams
commonwealth games
News
Isis fighters travel in a vehicle as they take part in a military parade along the streets of Syria's northern Raqqa province
i100
Arts and Entertainment
Southern charm: Nicolas Cage and Tye Sheridan in ‘Joe’
filmReview: Actor delivers astonishing performance in low budget drama
Life and Style
fashionLatex dresses hit the catwalk to raise awareness for HIV and Aids
Travel
travel
Independent
Travel Shop
the manor
Up to 70% off luxury travel
on city breaks Find out more
santorini
Up to 70% off luxury travel
on chic beach resorts Find out more
sardina foodie
Up to 70% off luxury travel
on country retreats Find out more
Latest stories from i100
Have you tried new the Independent Digital Edition apps?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Senior Risk Manager - Banking - London - £650

    £600 - £650 per day: Orgtel: Conduct Risk Liaison Manager - Banking - London -...

    Commercial Litigation Associate

    Highly Attractive Package: Austen Lloyd: CITY - COMMERCIAL LITIGATION - GLOBAL...

    Systems Manager - Dynamics AX

    £65000 - £75000 per annum + Benefits: Progressive Recruitment: The client is a...

    Service Delivery Manager (Software Development, Testing)

    £40000 - £45000 per annum: Ashdown Group: A well-established software house ba...

    Day In a Page

    Evan Davis: The BBC’s wolf in sheep’s clothing to take over at Newsnight

    The BBC’s wolf in sheep’s clothing

    What will Evan Davis be like on Newsnight?
    Finding the names for America’s shame: What happens to the immigrants crossing the US-Mexico border without documents who never make it past the Arizona desert?

    Finding the names for America’s shame

    The immigrants crossing the US-Mexico border without documents who never make it past the Arizona desert
    Backhanders, bribery and abuses of power have soared in China as economy surges

    Bribery and abuses of power soar in China

    The bribery is fuelled by the surge in China's economy but the rules of corruption are subtle and unspoken, finds Evan Osnos, as he learns the dark arts from a master
    Commonwealth Games 2014: Highland terriers stole the show at the opening ceremony

    Highland terriers steal the show at opening ceremony

    Gillian Orr explores why a dog loved by film stars and presidents is finally having its day
    German art world rocked as artists use renowned fat sculpture to distil schnapps

    Brewing the fat from artwork angers widow of sculptor

    Part of Joseph Beuys' 1982 sculpture 'Fettecke' used to distil schnapps
    BBC's The Secret History of Our Streets reveals a fascinating window into Britain's past

    BBC takes viewers back down memory lane

    The Secret History of Our Streets, which returns with three films looking at Scottish streets, is the inverse of Benefits Street - delivering warmth instead of cynicism
    Joe, film review: Nicolas Cage delivers an astonishing performance in low budget drama

    Nicolas Cage shines in low-budget drama Joe

    Cage plays an ex-con in David Gordon Green's independent drama, which has been adapted from a novel by Larry Brown
    How to make your own gourmet ice lollies, granitas, slushy cocktails and frozen yoghurt

    Make your own ice lollies and frozen yoghurt

    Think outside the cool box for this summer's tempting frozen treats
    Ford Fiesta is UK's most popular car of all-time, with sales topping 4.1 million since 1976

    Fiesta is UK's most popular car of all-time

    Sales have topped 4.1 million since 1976. To celebrate this milestone, four Independent writers recall their Fiestas with pride
    10 best reed diffusers

    Heaven scent: 10 best reed diffusers

    Keep your rooms smelling summery and fresh with one of these subtle but distinctive home fragrances that’ll last you months
    Commonwealth Games 2014: Female boxers set to compete for first time

    Female boxers set to compete at Commonwealth Games for first time

    There’s no favourites and with no headguards anything could happen
    Five things we’ve learned so far about Manchester United under Louis van Gaal

    Five things we’ve learned so far about United under Van Gaal

    It’s impossible to avoid the impression that the Dutch manager is playing to the gallery a little
    Screwing your way to the top? Good for Lana Del Rey for helping kill that myth

    Screwing your way to the top?

    Good for Lana Del Rey for helping kill that myth, says Grace Dent
    Will the young Britons fighting in Syria be allowed to return home and resume their lives?

    Will Britons fighting in Syria be able to resume their lives?

    Tony Blair's Terrorism Act 2006 has made it an offence to take part in military action abroad with a "political, ideological, religious or racial motive"
    Beyoncé poses as Rosie the Riveter, the wartime poster girl who became a feminist pin-up

    Beyoncé poses as Rosie the Riveter

    The wartime poster girl became the ultimate American symbol of female empowerment