Cancer cure trials move from mice to men

Hope of new breakthrough as US authorities give go-ahead to treat 22 patients with white blood cells

In a major breakthrough in the search for a cure for cancer, the first human trials are to begin using a technique that has already been shown to destroy the disease in mice. The trials are the culmination of years of research prompted by the discovery of a cancer-proof mouse by researchers almost a decade ago.

Tests on humans have been approved by the US Food and Drug Administration and were announced at a medical conference in Los Angeles yesterday.

More than 20 cancer patients will be given white blood cells with cancer-killing properties in an attempt to boost their immune system's fight against the deadly illness.

The work stems from experiments into the metabolism of a humble laboratory mouse whose immunity to cancer defied the repeated attempts of scientists to kill it with high-level doses of cancer cells. White blood cells taken from the animal and its offspring were subsequently used to cure other mice of advanced cancers. The white blood cells destroyed the cancer cells but left normal cells alone.

This discovery encouraged scientists to study how people might be helped to fight off cancer by being given a boost of white blood cells called granulocytes. Laboratory tests have since shown how human granulocytes can destroy cervical, prostate and breast cancer cells, provided sufficient numbers of cancer-killing granulocytes from healthy donors are used.

Scientists are now confident that the treatment will prove just as successful in humans as it has been in mice. The human trials are being led by Dr Zheng Cui, from Wake Forest University in Winston-Salem, North Carolina, who said: "In mice, we've been able to eradicate even highly aggressive forms of malignancy with extremely large tumours. Hopefully, we will see the same results in humans. Our laboratory studies indicate that this cancer-fighting ability is even stronger in healthy humans."

Hundreds of donors will be recruited for the new treatment – which is called leukocyte infusion therapy – and a process similar to platelet donation will be used to collect the granulocytes. Twenty-two cancer patients in the US will receive the cells through transfusions, and their progress will be reviewed after three months.

The news has been welcomed by cancer charities. Dr Joanna Owens, senior science information officer at the charity Cancer Research UK, said: "This is an exciting approach to treating cancer and the results seen in human cell lines and mice are certainly impressive. Our immune system is an immensely powerful weapon in helping the body to fight disease, and our scientists are also investigating ways to harness it to treat cancer. It's great to see the results of a decade of research offer hope of a potential new treatment, and we look forward to following the progress of the planned clinical trials."

News
Sir David Attenborough
people
Life and Style
Young girl and bowl of cereal
food + drink
News
Comic miserablist Larry David in 'Curb Your Enthusiasm'
peopleDirector of new documentary Misery Loves Comedy reveals how he got them to open up
Arts and Entertainment
Henry VIII played by Damien Lewis
tvReview: Scheming queens-in-waiting, tangled lines of succession and men of lowly birth rising to power – sound familiar?
PROMOTED VIDEO
Life and Style
ebookNow available in paperback
ebooks
ebookPart of The Independent’s new eBook series The Great Composers
Sport
football
Arts and Entertainment
'The Archers' has an audience of about five million
radioA growing number of listeners are voicing their discontent; so loudly that even the BBC's director-general seems worried
News
i100
Arts and Entertainment
Ready to open the Baftas, rockers Kasabian are also ‘great film fans’
musicExclusive: Rockers promise an explosive opening to the evening
Life and Style
David Bowie by Duffy
fashion
Arts and Entertainment
Hell, yeah: members of the 369th Infantry arrive back in New York
booksWorld War Z author Max Brooks honours WW1's Harlem Hellfighters in new graphic novel
News
advertisingVideo: The company that brought you the 'Bud' 'Weis' 'Er' frogs and 'Wasssssup' ads, has something up its sleeve for Sunday's big match
Arts and Entertainment
tv
News
i100
Environment
Dame Vivienne Westwood speaking at a fracking protest outside Parliament on Monday (AP)
environment
Life and Style
tech
Latest stories from i100
Have you tried new the Independent Digital Edition apps?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Tradewind Recruitment: English Teacher

    Negotiable: Tradewind Recruitment: This post arises as a result of the need to...

    Tradewind Recruitment: Class Teacher Required ASAP In Uminster

    £120 - £150 per annum: Tradewind Recruitment: I am recruiting on instruction o...

    Ashdown Group: Head of Finance - Financial Director - London - £70,000

    £70000 per annum: Ashdown Group: Head of Finance - Financial Controller - Fina...

    Ashdown Group: Marketing Executive - Wimbledon, SW London

    £24000 - £28000 per annum + benefits: Ashdown Group: Marketing Executive - Wim...

    Day In a Page

    Isis hostage crisis: Militant group stands strong as its numerous enemies fail to find a common plan to defeat it

    Isis stands strong as its numerous enemies fail to find a common plan to defeat it

    The jihadis are being squeezed militarily and economically, but there is no sign of an implosion, says Patrick Cockburn
    Virtual reality thrusts viewers into the frontline of global events - and puts film-goers at the heart of the action

    Virtual reality: Seeing is believing

    Virtual reality thrusts viewers into the frontline of global events - and puts film-goers at the heart of the action
    Homeless Veterans appeal: MP says Coalition ‘not doing enough’

    Homeless Veterans appeal

    MP says Coalition ‘not doing enough’ to help
    Larry David, Steve Coogan and other comedians share stories of depression in new documentary

    Comedians share stories of depression

    The director of the new documentary, Kevin Pollak, tells Jessica Barrett how he got them to talk
    Has The Archers lost the plot with it's spicy storylines?

    Has The Archers lost the plot?

    A growing number of listeners are voicing their discontent over the rural soap's spicy storylines; so loudly that even the BBC's director-general seems worried, says Simon Kelner
    English Heritage adds 14 post-war office buildings to its protected lists

    14 office buildings added to protected lists

    Christopher Beanland explores the underrated appeal of these palaces of pen-pushing
    Human skull discovery in Israel proves humans lived side-by-side with Neanderthals

    Human skull discovery in Israel proves humans lived side-by-side with Neanderthals

    Scientists unearthed the cranial fragments from Manot Cave in West Galilee
    World War Z author Max Brooks honours WW1's Harlem Hellfighters in new graphic novel

    Max Brooks honours Harlem Hellfighters

    The author talks about race, legacy and his Will Smith film option to Tim Walker
    Why the league system no longer measures up

    League system no longer measures up

    Jon Coles, former head of standards at the Department of Education, used to be in charge of school performance rankings. He explains how he would reform the system
    Valentine's Day cards: 5 best online card shops

    Don't leave it to the petrol station: The best online card shops for Valentine's Day

    Can't find a card you like on the high street? Try one of these sites for individual, personalised options, whatever your taste
    Diego Costa: Devil in blue who upsets defences is a reminder of what Liverpool have lost

    Devil in blue Costa is a reminder of what Liverpool have lost

    The Reds are desperately missing Luis Suarez, says Ian Herbert
    Ashley Giles: 'I'll watch England – but not as a fan'

    Ashley Giles: 'I'll watch England – but not as a fan'

    Former one-day coach says he will ‘observe’ their World Cup games – but ‘won’t be jumping up and down’
    Greece elections: In times like these, the EU has far more dangerous adversaries than Syriza

    Greece elections

    In times like these, the EU has far more dangerous adversaries than Syriza, says Patrick Cockburn
    Holocaust Memorial Day: Nazi victims remembered as spectre of prejudice reappears

    Holocaust Memorial Day

    Nazi victims remembered as spectre of prejudice reappears over Europe
    Fortitude and the Arctic attraction: Our fascination with the last great wilderness

    Magnetic north

    The Arctic has always exerted a pull, from Greek myth to new thriller Fortitude. Gerard Gilbert considers what's behind our fascination with the last great wilderness