Dr John Revill was an ‘aggressive’ user of statins to treat heart disease in the 1980s / Asadour Guzelian
A Sheffield GP virtually wiped out heart disease in patients under 70

For one retired Sheffield doctor, the furore over recommendations to treat 4.5 million more people with cholesterol-reducing statins had a familiar ring to it. That's because Dr John Revill spent the last 25 years of his career as a Sheffield GP battling health authorities over his policy of "aggressively" using statins to prevent heart disease, strokes and heart attacks.

Before most doctors had heard of statins, Dr Revill was orchestrating a crusade against heart disease. This, he claims, saved more than 100 lives and reduced the death rate from heart disease to near zero in the deprived Greenhill area of south Sheffield, where he practised.

For this reason, Dr Revill was hailed as an "unsung hero" of the NHS when the National Institute of Health and Care Excellence (Nice) issued new guidelines on the use of statins, recommending wider prescribing to millions more people thought to be "at risk" of heart disease. Dr Revill was hailed as a "hero" by leading clinicians for his pioneering work in Sheffield since 1988.

Four in 10 adults in England, Wales and Northern Ireland are now eligible for statins, even though many are at low risk of a heart attack or stroke. The move, Nice says, will save lives. Cardiovascular disease, which includes heart attacks and strokes, is the UK's biggest killer, claiming 180,000 lives a year and is behind one in three deaths.

Statins reduce the build-up of fatty-plaques that lead to blockages in blood vessels.

Crucially, say Nice experts, the crusading doctor left a little-studied legacy of 30 years' worth of "meticulously collected" health and mortality data. And, according to an analysis of his data published in The British Journal of Cardiology last month, Dr Revill almost eradicated mortality from heart disease for patients aged under 70 on his patient list.

"We knew mortality from ischaemic heart disease was directly related to the levels of low-density lipoprotein cholesterol, and that by offering healthy lifestyle advice and prescribing statins to at-risk patients, we could eliminate mortality from these diseases," Dr Revill, who retired last year, told The IoS. And according to his own "carefully collected" figures, deaths from cardiovascular causes in the under-70s "dropped by nearly 90 per cent" between 1981 and 2012, while deaths from heart disease dropped by "more than 50 per cent" in the same period.

Dr Revill, years ahead of official guidelines, prescribed statins to patients at 15 per cent risk of heart attacks, when the national guidance then suggested only prescribing to those at 30 per cent risk.

Dr Revill admits that he was "effectively forced out by the local health authority" over his policy of aggressively prescribing statins, but adds that he doesn't "condemn them". He said: "That was just the way it was then, and for my part I couldn't turn around and tell patients that I wouldn't prescribe a treatment that I knew to work."