Experimental drug provides fresh hope for Alzheimer's patients
Thursday 27 June 2013
An experimental drug has been shown to halt memory loss in mice with a rodent version of Alzheimer's disease.
The molecule, called MW108, curbed the activity of an enzyme that is over-active in patients with Alzheimer's and promotes brain inflammation.
As well as stopping the progression of memory loss, it repaired broken communication links between brain cells.
"This is the starting point for the development of a new class of drugs," said study leader Professor Martin Watterson, from Northwestern University in Chicago, US.
"It's possible someday this class of drugs could be given early on to people to arrest certain aspects of Alzheimer's.
"I'm not aware of any other drug that has this effect on the central nervous system."
Changes in the brain start to occur 10 to 15 years before an Alzheimer's patient starts to suffer serious memory problems.
The findings are published in the online journal Public Library of Science ONE.
US co-author Dr Linda Van Eldik, from the University of Kentucky, said: "This class of drugs could be beneficial when the nerve cells are just beginning to become impaired."
The team now plans to refine the drug so it is stable and safe enough to be given to patients in a clinical trial.
Life & Style blogs
Direct from the trenches: The objects that defined the First World War
Amputee drummer gains 'superhuman' skills with robotic arm
Fenwicks department store withdraws Boy London clothing over 'Nazi' eagle logo complaints
Stevia wonder: The plant that's a super sugar alternative – and free from calories and carbs
International Women's Day 2014: Google makes 80 second video of inspirational women from across the world for animated Doodle
- 1 International Women's Day 2014: The shocking statistics that show why it is still so important
- 2 Orgasm machine to deliver climax at the push of a button
- 3 Dear 'The Sun', breast cancer isn't sexy
- 4 Teacher shows sex tape featuring herself to pupils during class by mistake
- 5 Singapore sting: Sky-high prices are pushing locals to the edge of affordability
£12000 per annum: Inspiring Interns: A small but growing chain of boutique hot...
£12000 per annum: Inspiring Interns: The company works with Tier 1 FTSE 100 Ba...
£45 - 60k Per Annum: Charter Selection: Highly profitable leisure brand, marke...
£30000 - £50000 per annum + Highly Competitive Salary: Austen Lloyd: Residenti...