Four glasses of wine is enough to harm your health, scientists say

Researchers at the University of Massachusetts Medical School found that a single alcohol binge can cause lasting damage to the body

Unwinding in the pub on a Friday night could be wrecking your health - just four glasses of wine is enough to cause lasting damage, scientist have found.

A single alcohol binge causes bacteria to leak from the gut, leading to increased levels of toxins in the blood, according to a study carried out the University of Massachusetts Medical School (UMASS).

And the damage could be caused by fewer drinks than you think  – researchers classed a binge as four or more alcoholic drinks for women and five or more for men, consumed over a roughly two-hour period.

Professor Gyongyi Szabo, who led the research, said: “We found that a single alcohol binge can elicit an immune response, potentially impacting the health of an otherwise healthy individual.

 “Our observations suggest that an alcohol binge is more dangerous than previously thought.”

To assess the negative impacts of binge drinking, 11 men and 14 women were given enough alcohol to raise their blood alcohol concentration (BAC) to at least 0.08g/dl in the space of an hour.

Blood samples were then taken for every 30 minutes for four hours after and then again 24 hours later.

The results, published in the journal PLOS ONE, showed that just one alcohol binge led to a rapid increase in endotoxins in the blood - these cause the body to produce immune cells involved in fever, inflammation and tissue destruction.

The researchers also found evidence of bacterial DNA in the bloodstream, showing that bacteria had entered the gut. It is then able to travel through the gut walls to other parts of the body.

Women had higher blood alcohol levels compared to men, as well as higher endotoxin levels.

Greeter gut permeability and increased endotoxin levels have previously been linked to many of the health problems associated with alcohol consumption, including liver disease.

PROMOTED VIDEO
Life and Style
ebookNow available in paperback
Life and Style
ebooksA superb mix of recipes serving up the freshest of local produce in a delicious range of styles
Arts and Entertainment
tvStrictly presenter returns to screens after Halloween accident
News
peopleFormer civil rights activist who was jailed for smoking crack cocaine has died aged 78
News
i100
News
Boxing promoter Kellie Maloney, formerly known as Frank Maloney, entered the 2014 Celebrity Big Brother house
people
Sport
Dwight Gayle (left) celebrates making it 1-1 with Crystal Palace captain Mile Jedinak
premier leagueReds falter to humbling defeat
Latest stories from i100
Have you tried new the Independent Digital Edition apps?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Austen Lloyd: Corporate Solicitor NQ+ Oxford

    Excellent Salary: Austen Lloyd: CORPORATE - Corporate Solicitor NQ+ An excelle...

    Reach Volunteering: Financial Trustee and Company Secretary

    Voluntary Only - Expenses Reimbursed: Reach Volunteering: A trustee (company d...

    Recruitment Genius: Senior Project Manager

    £45000 - £65000 per annum: Recruitment Genius: This is a fantastic opportunity...

    Recruitment Genius: Shopfitter

    Negotiable: Recruitment Genius: This is an opportunity to join a successful an...

    Day In a Page

    Mau Mau uprising: Kenyans still waiting for justice join class action over Britain's role in the emergency

    Kenyans still waiting for justice over Mau Mau uprising

    Thousands join class action over Britain's role in the emergency
    Isis in Iraq: The trauma of the last six months has overwhelmed the remaining Christians in the country

    The last Christians in Iraq

    After 2,000 years, a community will try anything – including pretending to convert to Islam – to avoid losing everything, says Patrick Cockburn
    Black Friday: Helpful discounts for Christmas shoppers, or cynical marketing by desperate retailers?

    Helpful discounts for Christmas shoppers, or cynical marketing by desperate retailers?

    Britain braced for Black Friday
    Bill Cosby's persona goes from America's dad to date-rape drugs

    From America's dad to date-rape drugs

    Stories of Bill Cosby's alleged sexual assaults may have circulated widely in Hollywood, but they came as a shock to fans, says Rupert Cornwell
    Clare Balding: 'Women's sport is kicking off at last'

    Clare Balding: 'Women's sport is kicking off at last'

    As fans flock to see England women's Wembley debut against Germany, the TV presenter on an exciting 'sea change'
    Oh come, all ye multi-faithful: The Christmas jumper is in fashion, but should you wear your religion on your sleeve?

    Oh come, all ye multi-faithful

    The Christmas jumper is in fashion, but should you wear your religion on your sleeve?
    Dr Charles Heatley: The GP off to do battle in the war against Ebola

    The GP off to do battle in the war against Ebola

    Dr Charles Heatley on joining the NHS volunteers' team bound for Sierra Leone
    Flogging vlogging: First video bloggers conquered YouTube. Now they want us to buy their books

    Flogging vlogging

    First video bloggers conquered YouTube. Now they want us to buy their books
    Saturday Night Live vs The Daily Show: US channels wage comedy star wars

    Saturday Night Live vs The Daily Show

    US channels wage comedy star wars
    When is a wine made in Piedmont not a Piemonte wine? When EU rules make Italian vineyards invisible

    When is a wine made in Piedmont not a Piemonte wine?

    When EU rules make Italian vineyards invisible
    Look what's mushrooming now! Meat-free recipes and food scandals help one growing sector

    Look what's mushrooming now!

    Meat-free recipes and food scandals help one growing sector
    Neil Findlay is more a pink shrimp than a red firebrand

    More a pink shrimp than a red firebrand

    The vilification of the potential Scottish Labour leader Neil Findlay shows how one-note politics is today, says DJ Taylor
    Bill Granger recipes: Tenderstem broccoli omelette; Fried eggs with Mexican-style tomato and chilli sauce; Pan-fried cavolo nero with soft-boiled egg

    Oeuf quake

    Bill Granger's cracking egg recipes
    Terry Venables: Wayne Rooney is roaring again and the world knows that England are back

    Terry Venables column

    Wayne Rooney is roaring again and the world knows that England are back
    Michael Calvin: Abject leadership is allowing football’s age-old sores to fester

    Abject leadership is allowing football’s age-old sores to fester

    Those at the top are allowing the same issues to go unchallenged, says Michael Calvin