MHRA to investigate how healthcare products are repackaged

The regulator of medicines is investigating whether there has been a systemic failure in the way healthcare products are repackaged as the Nurofen Plus recall widened to a police investigation into sabotage.

The Medicines and Healthcare products Regulatory Agency (MHRA) has highlighted concerns over the way in which left over packs of pills are recycled at pharmacies and wholesalers.

The manufacturer Reckitt Benckiser suspected foul play as it began working with police yesterday to establish how pain killing tablets were replaced by the anti-psychotic drug Seroquel XL.

The firm issued the recall of an estimated 250,000 packets in UK homes on Friday and stopped distribution after boxes were found containing other drugs.

There have been five reports of different batches of 32 tablet packets where blister strips were replaced with other manufacturer's medicines.

Four foil packs containing Seroquel XL 50mg were found in three Boots stores and an independent pharmacy in South London, while Pfizer's anti-epileptic drug Neurontin was found in 100mg capsules at an independent pharmacist in Northern Ireland.

Seroquel XL is a prescription-only drug used to treat disorders such as schizophrenia, mania and bipolar depression.

People who take Seroquel may experience sleepiness and are advised not to drive or operate any tools or machinery.

Two people are known to have taken Seroquel XL in error, but have not been adversely affected. No one has been recorded taking Neurontin from the packs. The drug may cause dizziness.

Medicines are routinely put into new packets when blister packs do not exactly match a GP's prescription, where a course requires a smaller number of pills than is used in standard boxes.

Last night the Department of Health confirmed three South London pharmacists involved were part of the Boots Group in Bromley, Beckenham and Victoria while a fourth was at an independent Pharmacist in Beckenham.

Reckitt Benckiser said Nurofen is manufactured in Nottingham where tablets are automatically packed into boxes on pallets and sent to distribution centres for despatch.

MRHA has not ruled out criminal tampering, but is also investigating whether pills could have been incorrectly repacked as part of "consolidation", where left over medicines are put in new boxes by pharmacies, or where pharmaceuticals are returned to wholesalers.

"Medicine consolidation [occurs] if you go to your pharmacist and you have a prescription for, say, six tablets and box might contain, for example, eight tablets. In that case the pharmacist might give you six and cut a blister down and take two tablets back," an MRHA spokesman said.

"The pharmacist can hold those tablets and reconsolidate them, and make them up into other packets and use them. That certainly has potential for a blister of Seroquel to get mixed in with Nurofen Plus tablets.

"We haven't ruled out tampering just as we have not ruled out consolidation or returns errors."

The MHRA is working with Reckitt Benckiser in the investigation and stressed returns and consolidation were two further lines of inquiry alongside sabotage.

In a briefing with The Independent on Sunday, the regulator advised it was unlikely that medicines could have been sent back to the factory where they were manufactured, adding that the mix of packets could have occurred in error at a wholesalers.

The investigation has almost entirely ruled out a manufacturing error as it was "not really feasible" there was a mix up at the factory because Seroquel maker AstraZenca uses a different manufacturing site.

A Reckitt Benckiser spokeswoman refused to be drawn on accusations of systemic failure involving consolidation or returns of medicines, adding that no lines of inquiry have yet been eliminated. "We are investigating fully and it's too early to speculate," she said last night.

The police said the Specialist Crime Directorate is now conducting an investigation after the incidents were referred to the Metropolitan Police Service on Friday.Boots UK said last night the firm "would not re-consolidate over the counter or prescription based medicines".

"As the UK's leading pharmacy-led health and beauty retailer, our customers' health and safety is of the utmost importance. If you are concerned about your Nurofen Plus, please return them to the pharmacy where they were purchased," a spokeswoman said.

Life and Style
ebookNow available in paperback
ebooks
ebookPart of The Independent’s new eBook series The Great Composers
  • Get to the point
Latest stories from i100
Have you tried new the Independent Digital Edition apps?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Recruitment Genius: Sales Executive - OTE £25,000

    £15000 - £25000 per annum: Recruitment Genius: This is an exciting opportunity...

    Recruitment Genius: SEO Account Manager

    £22000 - £28000 per annum: Recruitment Genius: An SEO Account Manager is requi...

    Guru Careers: .NET Developer / Web Developer

    £35-45K (DOE) + Benefits: Guru Careers: We are seeking a .NET Developer / Web ...

    Recruitment Genius: Commercial Manager - Plasma Processing

    Negotiable: Recruitment Genius: A Commercial Manager is required to join a lea...

    Day In a Page

    Revealed: Why Mohammed Emwazi chose the 'safe option' of fighting for Isis, rather than following his friends to al-Shabaab in Somalia

    Why Mohammed Emwazi chose Isis

    His friends were betrayed and killed by al-Shabaab
    'The solution can never be to impassively watch on while desperate people drown'
An open letter to David Cameron: Building fortress Europe has had deadly results

    Open letter to David Cameron

    Building the walls of fortress Europe has had deadly results
    Tory candidates' tweets not as 'spontaneous' as they seem - you don't say!

    You don't say!

    Tory candidates' election tweets not as 'spontaneous' as they appear
    Mubi: Netflix for people who want to stop just watching trash

    So what is Mubi?

    Netflix for people who want to stop just watching trash all the time
    The impossible job: how to follow Kevin Spacey?

    The hardest job in theatre?

    How to follow Kevin Spacey
    Armenian genocide: To continue to deny the truth of this mass human cruelty is close to a criminal lie

    Armenian genocide and the 'good Turks'

    To continue to deny the truth of this mass human cruelty is close to a criminal lie
    Lou Reed: The truth about the singer's upbringing beyond the biographers' and memoirists' myths

    'Lou needed care, but what he got was ECT'

    The truth about the singer's upbringing beyond
    Migrant boat disaster: This human tragedy has been brewing for four years and EU states can't say they were not warned

    This human tragedy has been brewing for years

    EU states can't say they were not warned
    Women's sportswear: From tackling a marathon to a jog in the park, the right kit can help

    Women's sportswear

    From tackling a marathon to a jog in the park, the right kit can help
    Hillary Clinton's outfits will be as important as her policies in her presidential bid

    Clinton's clothes

    Like it or not, her outfits will be as important as her policies
    NHS struggling to monitor the safety and efficacy of its services outsourced to private providers

    Who's monitoring the outsourced NHS services?

    A report finds that private firms are not being properly assessed for their quality of care
    Zac Goldsmith: 'I'll trigger a by-election over Heathrow'

    Zac Goldsmith: 'I'll trigger a by-election over Heathrow'

    The Tory MP said he did not want to stand again unless his party's manifesto ruled out a third runway. But he's doing so. Watch this space
    How do Greek voters feel about Syriza's backtracking on its anti-austerity pledge?

    How do Greeks feel about Syriza?

    Five voters from different backgrounds tell us what they expect from Syriza's charismatic leader Alexis Tsipras
    From Iraq to Libya and Syria: The wars that come back to haunt us

    The wars that come back to haunt us

    David Cameron should not escape blame for his role in conflicts that are still raging, argues Patrick Cockburn
    Sam Baker and Lauren Laverne: Too busy to surf? Head to The Pool

    Too busy to surf? Head to The Pool

    A new website is trying to declutter the internet to help busy women. Holly Williams meets the founders