Scientists find the origin of 'bad' fat linked to heart disease and cancer

People can still carry visceral fat around their organs without it showing in their weight

Science Editor

Scientists have discovered the origin of the “bad” kind of fat found in the body which is linked with heart disease, cancer and other serious obesity-related illnesses, even though people carrying it can look slim.

The fat that builds up around abdominal organs such as the heart, kidney and intestine – known as visceral fat – is considered a silent killer because it’s possible for people to have a lot of it without looking particularly overweight.

It is more dangerous than the subcutaneous fat layers stored beneath the skin, and now researchers have found that it stems from a different source because it derives from a specific type of cell found in the developing embryo when it is still in the womb.

The discovery could eventually lead to new ways of controlling how this kind of cell contributes to the bad fat surrounding the vital organs so that it becomes possible to lower the chances of developing the kind of obesity that raises the risk of serious disease, they said.

A study on genetically modified mice found that 80 per cent of the visceral fat of the abdomen comes from embryonic cells known from a gene that they express called Wt1, which is linked with kidney tumours. Subcutaneous fat has a different origin and does not express the Wt1 gene, the researchers found.

“Determining the origins of good and bad fat has been one of the big unanswered questions in obesity research. We’ve now shown that most bad fat comes from cells expressing the Wt1 gene in the later stages of pregnancy,” said You-Ying Chau of Edinburgh University.

“We also found that cells expressing Wt1 continue to act as a source of visceral fat into adulthood where they may be influenced by external factors such as diet. If we would find a way to control the regulation of these cells, we might be able to stop the body laying down any more bad fat around the organ,” said Dr Chau, the lead author of the study in Nature Cell Biology.

Professor Nick Hastie of the Medical Research Council’s Human Genetics Unit in Edinburgh said although the visceral fat of the abdomen is formed after birth, it originates from embryonic cells in the womb which are also involved with forming the protective mesothelium membrane around the six visceral fat depots of the abdomen.

“We found strong evidence for the existence of a mesothelium, which was a big surprise because nobody thought this membrane existed in fat. It seems that not only does the mesothelium help to produce the cells that make the fat, it also surrounds the fat, making it into a neat little organ,” Professor Hastie said.

News
A 1930 image of the Karl Albrecht Spiritousen and Lebensmittel shop, Essen. The shop was opened by Karl and Theo Albrecht’s mother; the brothers later founded Aldi
people
Arts and Entertainment
Standing the test of time: Michael J Fox and Christopher Lloyd in 'Back to the Future'
filmA cult movie event aims to immerse audiences of 80,000 in ‘Back to the Future’. But has it lost its magic?
Arts and Entertainment
Flora Spencer-Longhurst as Lavinia, William Houston as Titus Andronicus and Dyfan Dwyfor as Lucius
theatreThe Shakespeare play that proved too much for more than 100 people
News
exclusivePunk icon Viv Albertine on Sid Vicious, complacent white men, and why free love led to rape
PROMOTED VIDEO
Life and Style
ebookA wonderful selection of salads, starters and mains featuring venison, grouse and other game
Arts and Entertainment
Stir crazy: Noel Fielding in 'Luxury Comedy 2: Tales from Painted Hawaii'
comedyAs ‘Luxury Comedy’ returns, Noel Fielding on why mainstream success scares him and what the future holds for 'The Boosh'
Life and Style
Flow chart: Karl Landsteiner discovered blood types in 1900, yet scientists have still not come up with an explanation for their existence
lifeAll of us have one. Yet even now, it’s a matter of debate what they’re for
Arts and Entertainment
'Weird Al' Yankovic, or Alfred Matthew, at the 2014 Los Angeles Film Festival Screening of
musicHis latest video is an ode to good grammar. But what do our experts think he’s missed out?
Sport
New Real Madrid signing James Rodríguez with club president Florentino Perez
sportColombian World Cup star completes £63m move to Spain
Travel
Hotel Tour d’Auvergne in Paris launches pay-what-you-want
travelIt seems fraught with financial risk, but the policy has its benefits
Arts and Entertainment
booksThe best children's books for this summer
Life and Style
News to me: family events were recorded in the personal columns
techFamily events used to be marked in the personal columns. But now Facebook has usurped that
Independent
Travel Shop
the manor
Up to 70% off luxury travel
on city breaks Find out more
santorini
Up to 70% off luxury travel
on chic beach resorts Find out more
sardina foodie
Up to 70% off luxury travel
on country retreats Find out more
Latest stories from i100
Have you tried new the Independent Digital Edition apps?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Sustainability Manager

    Competitive: The Green Recruitment Company: Job Title: Scheme Manager (BREEAM)...

    Graduate Sustainability Professional

    Flexible, depending on experience: The Green Recruitment Company: Job Title: T...

    Programme Director - Conduct Risk - London

    £850 - £950 per day: Orgtel: Programme Director - Conduct Risk - Banking - £85...

    Project Coordinator/Order Entry, SC Clear

    £100 - £110 per day: Orgtel: Project Coordinator/Order Entry Hampshire

    Day In a Page

    Noel Fielding's 'Luxury Comedy': A land of the outright bizarre

    Noel Fielding's 'Luxury Comedy'

    A land of the outright bizarre
    What are the worst 'Word Crimes'?

    What are the worst 'Word Crimes'?

    ‘Weird Al’ Yankovic's latest video is an ode to good grammar. But what do The Independent’s experts think he’s missed out?
    Can Secret Cinema sell 80,000 'Back to the Future' tickets?

    The worst kept secret in cinema

    A cult movie event aims to immerse audiences of 80,000 in ‘Back to the Future’. But has it lost its magic?
    Facebook: The new hatched, matched and dispatched

    The new hatched, matched and dispatched

    Family events used to be marked in the personal columns. But now Facebook has usurped the ‘Births, Deaths and Marriages’ announcements
    Why do we have blood types?

    Are you my type?

    All of us have one but probably never wondered why. Yet even now, a century after blood types were discovered, it’s a matter of debate what they’re for
    Honesty box hotels: You decide how much you pay

    Honesty box hotels

    Five hotels in Paris now allow guests to pay only what they think their stay was worth. It seems fraught with financial risk, but the honesty policy has its benefit
    Commonwealth Games 2014: Why weight of pressure rests easy on Michael Jamieson’s shoulders

    Michael Jamieson: Why weight of pressure rests easy on his shoulders

    The Scottish swimmer is ready for ‘the biggest race of my life’ at the Commonwealth Games
    Some are reformed drug addicts. Some are single mums. All are on benefits. But now these so-called 'scroungers’ are fighting back

    The 'scroungers’ fight back

    The welfare claimants battling to alter stereotypes
    Amazing video shows Nasa 'flame extinguishment experiment' in action

    Fireballs in space

    Amazing video shows Nasa's 'flame extinguishment experiment' in action
    A Bible for billionaires

    A Bible for billionaires

    Find out why America's richest men are reading John Brookes
    Paranoid parenting is on the rise - and our children are suffering because of it

    Paranoid parenting is on the rise

    And our children are suffering because of it
    For sale: Island where the Magna Carta was sealed

    Magna Carta Island goes on sale

    Yours for a cool £4m
    Phone hacking scandal special report: The slide into crime at the 'News of the World'

    The hacker's tale: the slide into crime at the 'News of the World'

    Glenn Mulcaire was jailed for six months for intercepting phone messages. James Hanning tells his story in a new book. This is an extract
    We flinch, but there are degrees of paedophilia

    We flinch, but there are degrees of paedophilia

    Child abusers are not all the same, yet the idea of treating them differently in relation to the severity of their crimes has somehow become controversial
    The truth about conspiracy theories is that some require considering

    The truth about conspiracy theories is that some require considering

    For instance, did Isis kill the Israeli teenagers to trigger a war, asks Patrick Cockburn