Virus responsible for swine flu pandemic becoming increasingly resistant to Tamiflu

2009 outbreak may have caused the deaths of up to 579,000 people

The virus responsible for the “swine flu” pandemic of 2009 is becoming increasingly resistant to the main drug used to treat it, new research has shown.

An increasing number of cases of the virus, H1NI, are being found with developing resistance to oseltamivir – trade name Tamiflu – which was stockpiled in large amounts by Governments, including the British Government, when it was feared the new swine flu mutation would irresistibly sweep the world.

First detected in Mexico, the 2009 virus was a new strain of H1N1 – itself responsible for the disastrous flu pandemic of 1918 – which combined with a Eurasian pig flu virus to become newly potent.

The resultant pandemic struck over 74 countries, and although deaths were initially assessed by the World Health Organisation at 18,500, the WHO later admitted this was probably a gross underestimate.

A 2012 medical study by the journal ITALS Lancet Infectious Diseases OFFITALS suggested that in fact it may have caused the deaths of up to 579,000 people. 

Tamiflu, made by the giant Swiss pharmaceutical company, Hoffman-La Roche, was the main drug against the outbreak – but now Australian scientists are finding that it is encountering increased resistance.

Dr Aeron Hurt, of the WHO Collaborating Centre for Reference and Research on Influenza in Melbourne, analysed with colleagues circulating H1N1 strains, and found that although the overall frequency of Tamiflu resistance was relatively low (approximately two per cent of strains tested) an increasing proportion of these viruses were being detected from patients not being treated with Tamiflu.

This suggests a resistant strain could be emerging since it must be being transmitted to these patients never treated with that drug. 

A widespread cluster of cases of Tamiflu-resistant influenza in Newcastle, New South Wales, in 2011 detected by surveillance conducted by Dr Hurt and colleagues, represents the most widespread outbreak of Tamiflu-resistant H1N, and generated significant concern that these strains may spread outside of Australia.

Similar resistant strains have since been detected in Europe, but at this stage only on an ad hoc basis. “However, the trend observed in Australia of a greater proportion of resistant cases being detected in untreated community patients is also being observed both in the USA and Europe,” says Dr Hurt.

Dr Hurt’s research was presented at the annual scientific meeting of the Australasian Society for Infectious Diseases (ASID) in Canberra.

Voices
There will be a chance to bid for a rare example of the SAS Diary, collated by a former member of the regiment in the aftermath of World War II but only published – in a limited run of just 5,000 – in 2011
charity appealTime is running out to secure your favourite lot as our auction closes at 2pm tomorrow
Arts and Entertainment
Mark Wright and Bianca Miller in the final of The Apprentice
tvMark Wright and Bianca Miller fight for Lord Sugar's investment
Arts and Entertainment
X Factor winner Ben Haenow has scored his first Christmas number one
music
News
news
PROMOTED VIDEO
Life and Style
ebookNow available in paperback
Life and Style
ebooksA superb mix of recipes serving up the freshest of local produce in a delicious range of styles
Arts and Entertainment
James May, Jeremy Clarkson and Richard Hammond in the Top Gear Patagonia Special
tv
News
File: James Woods attends the 52nd New York Film Festival at Walter Reade Theater on September 27, 2014
peopleActor was tweeting in wake of NYPD police shooting
News
Claudia Winkleman and co-host Tess Daly at the Strictly Come Dancing final
people
News
i100
Extras
indybest
News
peopleLiam Williams posted photo of himself dressed as Wilfried Bony
Sport
Martin Skrtel heads in the dramatic equaliser
SPORTLiverpool vs Arsenal match report: Bandaged Martin Skrtel heads home in the 97th-minute
Arts and Entertainment
The Apprentice finalists Mark Wright and Bianca Miller
tvBut who should win The Apprentice?
News
The monkey made several attempts to revive his friend before he regained consciousness
video
Extras
indybest
News
Elton John and David Furnish will marry on 21 December 2014
peopleSinger posts pictures of nuptials throughout the day
Life and Style
A still from the 1939 film version of Margaret Mitchell's 'Gone with the Wind'
life
Latest stories from i100
Have you tried new the Independent Digital Edition apps?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Recruitment Genius: Telesales & Customer Service Executives - Outbound & Inbound

    £7 - £9 per hour: Recruitment Genius: Are you outgoing? Do you want to work in...

    Recruitment Genius: National Account Manager / Key Account Sales

    £30000 - £35000 per annum: Recruitment Genius: An opportunity has arisen for a...

    Recruitment Genius: Operations Manager

    £30000 - £35000 per annum: Recruitment Genius: An exciting opportunity to join...

    Recruitment Genius: Recruitment Consultant

    £30000 - £35000 per annum: Recruitment Genius: We have an excellent role for a...

    Day In a Page

    The week Hollywood got scared and had to grow up a bit

    The week Hollywood got scared and had to grow up a bit

    Sony suffered a chorus of disapproval after it withdrew 'The Interview', but it's not too late for it to take a stand, says Joan Smith
    From Widow Twankey to Mother Goose, how do the men who play panto dames get themselves ready for the performance of a lifetime?

    Panto dames: before and after

    From Widow Twankey to Mother Goose, how do the men who play panto dames get themselves ready for the performance of a lifetime?
    Thirties murder mystery novel is surprise runaway Christmas hit

    Thirties murder mystery novel is surprise runaway Christmas hit

    Booksellers say readers are turning away from dark modern thrillers and back to the golden age of crime writing
    Anne-Marie Huby: 'Charities deserve the best,' says founder of JustGiving

    Anne-Marie Huby: 'Charities deserve the best'

    Ten million of us have used the JustGiving website to donate to good causes. Its co-founder says that being dynamic is as important as being kind
    The botanist who hunts for giant trees at Kew Gardens

    The man who hunts giants

    A Kew Gardens botanist has found 25 new large tree species - and he's sure there are more out there
    The 12 ways of Christmas: Spare a thought for those who will be working to keep others safe during the festive season

    The 12 ways of Christmas

    We speak to a dozen people who will be working to keep others safe, happy and healthy over the holidays
    Birdwatching men have a lot in common with their feathered friends, new study shows

    The male exhibits strange behaviour

    A new study shows that birdwatching men have a lot in common with their feathered friends...
    Diaries of Evelyn Waugh, Virginia Woolf and Noël Coward reveal how they coped with the December blues

    Famous diaries: Christmas week in history

    Noël Coward parties into the night, Alan Clark bemoans the cost of servants, Evelyn Waugh ponders his drinking…
    From noble to narky, the fall of the open letter

    From noble to narky, the fall of the open letter

    The great tradition of St Paul and Zola reached its nadir with a hungry worker's rant to Russell Brand, says DJ Taylor
    A Christmas ghost story by Alison Moore: A prodigal daughter has a breakthrough

    A Christmas ghost story by Alison Moore

    The story was published earlier this month in 'Poor Souls' Light: Seven Curious Tales'
    Marian Keyes: The author on her pre-approved Christmas, true love's parking implications and living in the moment

    Marian Keyes

    The author on her pre-approved Christmas, true love's parking implications and living in the moment
    Bill Granger recipes: Our chef creates an Italian-inspired fish feast for Christmas Eve

    Bill Granger's Christmas Eve fish feast

    Bill's Italian friends introduced him to the Roman Catholic custom of a lavish fish supper on Christmas Eve. Here, he gives the tradition his own spin…
    Liverpool vs Arsenal: Brendan Rodgers is fighting for his reputation

    Rodgers fights for his reputation

    Liverpool manager tries to stay on his feet despite waves of criticism
    Amir Khan: 'The Taliban can threaten me but I must speak out... innocent kids, killed over nothing. It’s sick in the mind'

    Amir Khan attacks the Taliban

    'They can threaten me but I must speak out... innocent kids, killed over nothing. It’s sick in the mind'
    Michael Calvin: Sepp Blatter is my man of the year in sport. Bring on 2015, quick

    Michael Calvin's Last Word

    Sepp Blatter is my man of the year in sport. Bring on 2015, quick