Virus responsible for swine flu pandemic becoming increasingly resistant to Tamiflu

2009 outbreak may have caused the deaths of up to 579,000 people

The virus responsible for the “swine flu” pandemic of 2009 is becoming increasingly resistant to the main drug used to treat it, new research has shown.

An increasing number of cases of the virus, H1NI, are being found with developing resistance to oseltamivir – trade name Tamiflu – which was stockpiled in large amounts by Governments, including the British Government, when it was feared the new swine flu mutation would irresistibly sweep the world.

First detected in Mexico, the 2009 virus was a new strain of H1N1 – itself responsible for the disastrous flu pandemic of 1918 – which combined with a Eurasian pig flu virus to become newly potent.

The resultant pandemic struck over 74 countries, and although deaths were initially assessed by the World Health Organisation at 18,500, the WHO later admitted this was probably a gross underestimate.

A 2012 medical study by the journal ITALS Lancet Infectious Diseases OFFITALS suggested that in fact it may have caused the deaths of up to 579,000 people. 

Tamiflu, made by the giant Swiss pharmaceutical company, Hoffman-La Roche, was the main drug against the outbreak – but now Australian scientists are finding that it is encountering increased resistance.

Dr Aeron Hurt, of the WHO Collaborating Centre for Reference and Research on Influenza in Melbourne, analysed with colleagues circulating H1N1 strains, and found that although the overall frequency of Tamiflu resistance was relatively low (approximately two per cent of strains tested) an increasing proportion of these viruses were being detected from patients not being treated with Tamiflu.

This suggests a resistant strain could be emerging since it must be being transmitted to these patients never treated with that drug. 

A widespread cluster of cases of Tamiflu-resistant influenza in Newcastle, New South Wales, in 2011 detected by surveillance conducted by Dr Hurt and colleagues, represents the most widespread outbreak of Tamiflu-resistant H1N, and generated significant concern that these strains may spread outside of Australia.

Similar resistant strains have since been detected in Europe, but at this stage only on an ad hoc basis. “However, the trend observed in Australia of a greater proportion of resistant cases being detected in untreated community patients is also being observed both in the USA and Europe,” says Dr Hurt.

Dr Hurt’s research was presented at the annual scientific meeting of the Australasian Society for Infectious Diseases (ASID) in Canberra.

PROMOTED VIDEO
Life and Style
ebookNow available in paperback
Life and Style
ebooksA superb mix of recipes serving up the freshest of local produce in a delicious range of styles
Arts and Entertainment
John Hurt will voice Prince Bolkonsky in Radio 4's War and Peace
radioRadio 4 to broadcast 10-hour adaptation of War and Peace on first day of 2015
News
people
Arts and Entertainment
Avatar grossed $2.8bn at the box office after its release in 2009
filmJames Cameron is excited
News
news

Lincoln MP Karl McCartney 'denied all knowledge' of the Twitter activity

Arts and Entertainment
Joel Edgerton, John Turturro and Christian Bale in Exodus: Gods and Kings
filmDirector said film would 'never have been financed' with ethnic minority actors in key roles
Arts and Entertainment
Stik on the crane as he completed the mural
art
News
The author PD James, who died on 27 November 2014
people

Detective novelist who wrote Death comes to Pemberley passed away peacefully at her home, aged 94

Arts and Entertainment
Jennifer Lawrence as Katniss Everdeen in The Hunger Games: Mockingjay Part 1
arts + ents
Life and Style
tech

Sites using the popular Gigya comment platform were attacked by the Syrian Electronic Army (SEA)

Extras
indybest
News
people
Latest stories from i100
Have you tried new the Independent Digital Edition apps?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Argyll Scott International: Service Desk Analyst

    £20000 - £22000 per annum: Argyll Scott International: Service Desk Analyst Re...

    h2 Recruit Ltd: Business Development Executive - Software

    £20000 - £25000 per annum + 55,000 OTE + benifits: h2 Recruit Ltd: Software Sa...

    Argyll Scott International: 2x Service Desk Analyst

    £20000 - £22000 per annum: Argyll Scott International: Service Desk Analyst Re...

    Langley James : IT Project Manager; 6 month FTC; Brighton; £400p/d

    £400 - £420 per day: Langley James : IT Project Manager; 6 month FTC; Brighton...

    Day In a Page

    Cameron, Miliband and Clegg join forces for Homeless Veterans campaign

    Cameron, Miliband and Clegg join forces for Homeless Veterans campaign

    It's in all our interests to look after servicemen and women who fall on hard times, say party leaders
    Millionaire Sol Campbell wades into wealthy backlash against Labour's mansion tax

    Sol Campbell cries foul at Labour's mansion tax

    The former England defender joins Myleene Klass, Griff Rhys Jones and Melvyn Bragg in criticising proposals
    Nicolas Sarkozy returns: The ex-President is preparing to fight for the leadership of France's main opposition party – but will he win big enough?

    Sarkozy returns

    The ex-President is preparing to fight for the leadership of France's main opposition party – but will he win big enough?
    Is the criticism of Ed Miliband a coded form of anti-Semitism?

    Is the criticism of Miliband anti-Semitic?

    Attacks on the Labour leader have coalesced around a sense that he is different, weird, a man apart. But is the criticism more sinister?
    Ouija boards are the must-have gift this Christmas, fuelled by a schlock horror film

    Ouija boards are the must-have festive gift

    Simon Usborne explores the appeal - and mysteries - of a century-old parlour game
    There's a Good Girl exhibition: How female creatives are changing the way women are portrayed in advertising

    In pictures: There's a Good Girl exhibition

    The new exhibition reveals how female creatives are changing the way women are portrayed in advertising
    UK firm Biscuiteers is giving cookies a makeover - from advent calendars to doll's houses

    UK firm Biscuiteers is giving cookies a makeover

    It worked with cupcakes, doughnuts and macarons so no wonder someone decided to revamp the humble biscuit
    Can SkySaga capture the Minecraft magic?

    Can SkySaga capture the Minecraft magic?

    It's no surprise that the building game born in Sweden in 2009 and now played by millions, has imitators keen to construct their own mega money-spinner
    The King's School is way ahead of the pack when it comes to using the latest classroom technology

    Staying connected: The King's School

    The school in Cambridgeshire is ahead of the pack when it comes to using the latest classroom technology. Richard Garner discovers how teachers and pupils stay connected
    Christmas 2014: 23 best women's perfumes

    Festively fragrant: the best women's perfumes

    Give a loved one a luxe fragrance this year or treat yourself to a sensual pick-me-up
    Arsenal vs Borussia Dortmund: Alex Oxlade-Chamberlain celebrates century with trademark display of speed and intuition

    Arsenal vs Borussia Dortmund

    The Ox celebrates century with trademark display of speed and intuition
    Billy Joe Saunders vs Chris Eubank Jnr: When two worlds collide

    When two worlds collide

    Traveller Billy Joe Saunders did not have a pampered public-school upbringing - unlike Saturday’s opponent Chris Eubank Jnr
    Homeless Veterans Christmas Appeal: Drifting and forgotten - turning lives around for ex-soldiers

    Homeless Veterans Christmas Appeal: Turning lives around for ex-soldiers

    Our partner charities help veterans on the brink – and get them back on their feet
    Putin’s far-right ambition: Think-tank reveals how Russian President is wooing – and funding – populist parties across Europe to gain influence in the EU

    Putin’s far-right ambition

    Think-tank reveals how Russian President is wooing – and funding – populist parties across Europe to gain influence in the EU
    Tove Jansson's Moominland: What was the inspiration for Finland's most famous family?

    Escape to Moominland

    What was the inspiration for Finland's most famous family?