Waste substance found in blood can protect against effects of Parkinson’s disease

 

A waste substance found in the blood that is linked with gout and diabetes has been found to protect against the effects of Parkinson’s disease, a study has found.

High levels of urate, which is produced as a waste by-product of normal metabolism, can actually protect the brain against the degeneration of key nerve cells seen in Parkinson’s patients, scientists said.

A study involving genetically modified laboratory mice found that higher-than-usual amounts of urate in the bloodstream appear to reduce the loss of cells that produce dopamine, a neuro-transmitter that is lacking in Parkinson’s patients.

Mice with abnormally low urate levels suffered a significantly greater loss of dopamine cells in the brain. Scientists believe the results suggest that urate, an anti-oxidant, could protect Parkinson’s patients from further neuro-degeneration.

“Our study is the first demonstration in an animal model that genetic elevation of urate can protect dopamine neurons from degeneration and that lowering urate can conversely exacerbate neuro-degeneration,” said Xiqun Chen of the Massachusetts General Hospital in Boston.

The study, published in the Proceedings of the National Academy of Sciences, follows earlier research showing that people with high levels of urate in their blood are less likely than other individuals to develop Parkinson’s disease.

Michael Schwarzschild, director of the hospital’s Molecular Neurobiology Laboratory, said: “The biology of urate in the brain is largely unexplored. Understanding both urate’s mechanisms of protection and the way its levels are regulated in the body will help us to determine how to better harness its protective effects, if they are substantiated.”

Life and Style
ebookNow available in paperback
ebooks
ebookPart of The Independent’s new eBook series The Great Composers
  • Get to the point
Latest stories from i100
Have you tried new the Independent Digital Edition apps?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Recruitment Genius: In House Counsel - Contracts

    Negotiable: Recruitment Genius: This leading supplier of compliance software a...

    Recruitment Genius: Associate System Engineer

    £24000 - £30000 per annum: Recruitment Genius: The Associate System Engineer r...

    Recruitment Genius: Executive Assistant

    Negotiable: Recruitment Genius: An Executive Assistant is required to join a l...

    Ashdown Group: Marketing Manager - B2B, Corporate - City, London

    £45000 - £50000 per annum + benefits : Ashdown Group: A highly successful, glo...

    Day In a Page

    General Election 2015: The masterminds behind the scenes

    The masterminds behind the election

    How do you get your party leader to embrace a message and then stick to it? By employing these people
    Machine Gun America: The amusement park where teenagers go to shoot a huge range of automatic weapons

    Machine Gun America

    The amusement park where teenagers go to shoot a huge range of automatic weapons
    The ethics of pet food: Why are we are so selective in how we show animals our love?

    The ethics of pet food

    Why are we are so selective in how we show animals our love?
    How Tansy Davies turned 9/11 into her opera 'Between Worlds'

    How a composer turned 9/11 into her opera 'Between Worlds'

    Tansy Davies makes her operatic debut with a work about the attack on the Twin Towers. Despite the topic, she says it is a life-affirming piece
    11 best bedside tables

    11 best bedside tables

    It could be the first thing you see in the morning, so make it work for you. We find night stands, tables and cabinets to wake up to
    Italy vs England player ratings: Did Andros Townsend's goal see him beat Harry Kane and Wayne Rooney to top marks?

    Italy vs England player ratings

    Did Townsend's goal see him beat Kane and Rooney to top marks?
    Danny Higginbotham: An underdog's tale of making the most of it

    An underdog's tale of making the most of it

    Danny Higginbotham on being let go by Manchester United, annoying Gordon Strachan, utilising his talents to the full at Stoke and plunging into the world of analysis
    Audley Harrison's abusers forget the debt he's due, but Errol Christie will always remember what he owes the police

    Steve Bunce: Inside Boxing

    Audley Harrison's abusers forget the debt he's due, but Errol Christie will always remember what he owes the police
    No postcode? No vote

    Floating voters

    How living on a houseboat meant I didn't officially 'exist'
    Louis Theroux's affable Englishman routine begins to wear thin

    By Reason of Insanity

    Louis Theroux's affable Englishman routine begins to wear thin
    Power dressing is back – but no shoulderpads!

    Power dressing is back

    But banish all thoughts of Eighties shoulderpads
    Spanish stone-age cave paintings 'under threat' after being re-opened to the public

    Spanish stone-age cave paintings in Altamira 'under threat'

    Caves were re-opened to the public
    'I was the bookies’ favourite to be first to leave the Cabinet'

    Vince Cable interview

    'I was the bookies’ favourite to be first to leave the Cabinet'
    Election 2015: How many of the Government's coalition agreement promises have been kept?

    Promises, promises

    But how many coalition agreement pledges have been kept?
    The Gaza fisherman who built his own reef - and was shot dead there by an Israeli gunboat

    The death of a Gaza fisherman

    He built his own reef, and was fatally shot there by an Israeli gunboat