Losing weight at all costs can come at great expense
Wednesday 14 July 2010
From slimming supplements to prescription drugs, pharmacies are full of products destined to help lose weight, but their use can come at great expense, both financially and health-wise.
At the 11th International Congress on Obesity hosted in Stockholm, experts were clear when it came to over-the-counter slimming supplements: "save your money, the only thing you are going to lose is your money," said Judith Stern, a professor in the Departments of Nutrition and Internal Medicine at the University of California Davis.
Two studies presented at the congress showed supplements were ineffective.
Thomas Ellrott, a professor at the university of Goettingen in Germany, presented a study in which nine popular supplements, proposing nine different weight loss solutions, were tested against placebo pills in a controlled trial.
"There are scores of slimming supplements out there claiming weight-loss effects through all sorts of mechanisms of action... the market for these is huge, but unlike for regulated drugs, effectiveness does not have to be proven for these to be sold," he said.
The participants in his study that took weight loss supplements lost between one and two kilograms, while those taking the placebo lost 1.2 kg on average.
"Not a single product was any more effective than placebo pills in producing weight loss over the two months of the study, regardless of how it claims to work," he said.
Despite their proven lack of effectiveness, the market for supplements ranging from cabbage powder to fibre pills to plant extracts generates a whopping 13 billion dollars (10 billion euros) per year, said Igho Onakpoya of the Universities of Exeter and Plymouth in Britain.
"People think these supplements are a short cut to weight loss and may spend huge sums of money on them, but they may end up disappointed, frustrated and depressed," he said.
For a more effective chance at tackling weight loss, experts recommend turning to prescription drugs, but these are not free from side effects.
An anti-obesity drug that targeted the cannabinoid receptor CB1 had received all regulatory approvals but was then withdrawn from the European market after widespread use showed it carried a risk of psychiatric side effects.
"Depression is not an acceptable trade-off for weight loss," said Christian Elling, vice president of the Danish pharmaceutical laboratory 7TM Pharma.
His team is currently working to develop a new drug based on a molecule that acts the same way on organs and muscles linked to metabolism as the withdrawn drug, with the important difference that it does not penetrate the brain.
"The lack of significant exposure in the brain seen in our pre-clinical experiments provides optimism that blockade of the CB1 receptor may still be an effective and safe approach to treat obesity and related diseases," he said when presenting his laboratory's findings at the conference, adding more trials were still needed before commercialising the drug.
Other prescription drugs have been proven effective, allowing to shed up to 10 percent of total body weight, or eight to nine kilos (18 to 20 pounds) per year.
And even these are not health risk free, because of the psychological aspect of fighting against a weight surplus.
"Patients are often victims of their expectations," said Luc van Gaal, of the University of Antwerp in Belgium.
"If the patient is not happy because he's not losing weight fast enough or he wants to lose more, he starts experimenting, doubling doses... and then, (prescription drugs) become a health risk," he said, hinting that patients blinded by an obsession to slim down could manage to get their hands on medicine illegally.
Life & Style blogs
Airline food across the classes: Ever wondered what the other half are eating?
Coachella Festival 2015: from Kendall Jenner to Alexa Chung, stars and festival-goers parade their boho best
The onesie is so last year... meet the Sleepwalker
What do the emoji on Snapchat mean?
A bottle of wine a day is not bad for you and abstaining is worse than drinking, scientist claims
- 1 BBC election debate: The one photo that summed up the whole 90-minute leaders debate
- 2 18th century sex toy found in 'toilet of sword fighting school' in Poland
- 3 US? China? India? The 10 biggest economies in 2030 will be...
- 4 'I wish my teacher knew...': Young students share their 'heartbreaking' worries in notes
- 5 Rebecca Francis accuses Ricky Gervais of using 'influence' to target female hunters after receiving barrage of death threats
£30000 - £40000 per annum + Benefits: Ashdown Group: Front-End UI Application ...
£18000 - £26000 per annum: Recruitment Genius: They work with major vehicle ma...
£27000 per annum: Recruitment Genius: Domestic Service Only Engineers are requ...
£23600 - £27500 per annum: Recruitment Genius: The Employability Service withi...