The bus was ambushed in Dayrut, 170 miles south of Cairo and a group stronghold. Police said a boy in the road whistled on seeing the bus, and gunmen opened fire from fields.
Hospital sources said the dead tourist was Sharon Hill, 28, and those injured were David Wilson and Mike Smith, both 24.
The ambush is the second attack on foreign tourists in Egypt in less than a month. Seventy-two people have died and 93 been wounded this year in violence
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