“The idea that this xenophobic, fascist theory that we are going to ban Muslims from our country or we are going to kick 12 million Mexicans back down to the border and build a wall they are going to pay for - none of that is ever going to happen”.
Instead, Clooney said the hysteria surrounding the billionaire property mogul will die down.
“This country isn't going to do that. All this chatter is going to be going around for another two or three months but eventually all the insanity will stop and we will start to talk about issues that really matter.”
Trump remains the Republican favourite and is leading in the latest polls in eight of the 11 states that will vote on Super Tuesday - the round of primaries that will give a strong indication as to who will emerge as the most likely Republican candidate for November's election.
Donald Trump's most controversial quotes
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But Clooney, who is an ardent Democrat and human rights advocate, remains confident that Trump will not be triumphant.
“I feel very confident that, in the end, the issues will matter,” he said.
This is not the first time the Kentucky-born actor has been outspoken about Trump – in September last year he said Trump’s description of Mexican immigrants as “rapists” and “criminals” was “idiotic”.
Speaking at the Toronto Film Festival press conference Clooney said: “Clearly, what he said is idiotic, of course it’s idiotic.”
“Anybody who says as intolerant words as those should be laughed at and that’s pretty much what history will do”.
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