Five people were being questioned on suspicion of murder today after a 19-year-old man was found with fatal injuries.
Three men and two juveniles were arrested by police and remain in custody.
The victim was discovered at 12.30am yesterday by a member of the public in Holgate Avenue, Parson Cross, Sheffield.
He was taken to the Northern General Hospital by ambulance but died of his injuries about an hour later, a spokeswoman for South Yorkshire Police said.
Police would not comment on reports he had been stabbed.
Detectives believe the man, who has not yet been formally identified, may have attended a function at the White Horse pub on Halifax Road on Friday evening before leaving at 11pm.
The victim is thought to have been making his way home towards the Ecclesfield area when he was allegedly attacked.
A post-mortem examination was carried out but detectives are not prepared to release the results at this stage of their investigation, police added.
Formal identification of the victim is expected to take place today.
Police said two men and a juvenile were arrested on suspicion of murder and were being held at police stations in Sheffield.
Later, a spokesman said two further people, a man and a juvenile, were arrested on suspicion of murder in connection with the death.
He said the five people remained in custody assisting detectives with the investigation.