Desperately ill toddler Tia Pugh needs bone marrow transplant to save her life

Tia Pugh is believed to be the only person in the world suffering from a unique combination of illnesses

A "darling" three-year-old girl suffering from a rare combination of illnesses is in desperate need of a bone marrow transplant to save her life, doctors have said.

Tia Pugh, who suffers from an extremely rare form of immune deficiency - STAT1 deficiency - is believed to be the only person in the world to have a tuberculosis-like illness called mycobacteriym malmoense at the same time.

Despite months of hospital treatment and tests, medics have said that her only chance of a cure is a bone marrow transplant.

But her unique background - her father, Nick, is from Worcester, and her mother, Yupa, is Thai with Cambodian heritage - may make finding a genetic match extremely difficult.

Her parents have called for people to sign up to the bone marrow register to help Tia - who loves Peppa Pig and the Muppets - experience a childhood "full of fun and joy".

"Tia is our darling little daughter and it is heartbreaking to watch her suffer like this," Mr Pugh said.

"Now that the doctors have identified what's wrong we can at last get moving on finding a cure.

"But we have to be quick, and that cure is out of our hands until we can find a match."

He added: "All I can say to the people out there is please help us however you can, by signing up to the register or setting up a recruitment event in your area.

"Think how you would feel if it was your daughter, or your son, and you needed a stranger to help them survive. Childhood is supposed to be full of fun and joy, and that's all we want for our Tia.

"Please help us help her, by signing up to the bone marrow register."

Yupa and Nick Pugh with their three-year old daughter, Tia Doctors have tried different combinations of drugs to help Tia, who had a blood transfusion before she was two.

For months, she had to go to the hospital at 7am and 11pm every day to receive vital medicines.

Nurses visit her home daily at 11am and 3pm to help care for her, and Tia's mother has been trained to administer her antibiotics at home.

Tia, who "loves singing and dancing to Peppa Pig, the Muppets' Mahna-Mahna song and Fatboy Slim's Eat, Sleep, Rave, Repeat when she has the energy", is also fed through an intravenous tube each night.

Anthony Nolan, the UK charity which manages the bone marrow register, has urged people to sign up as donors, especially those of South East Asian and mixed-Asian heritage.

Henny Braund, Anthony Nolan chief executive, said: "Tia's situation is so difficult that it's hard to hear about.

"But it is precisely this kind of circumstance that Anthony Nolan was set up to help with. Over the last 40 years we have seen thousands of caring, selfless people put their names on the register and thousands of lives have been saved as a result.

"Now it is vital that we get the message out, especially to the South East Asian community, so that we can find a match for Tia as soon as possible. Please help however you can."

Every year in the UK, around 1,800 people in the UK need a bone marrow or stem cell transplant - usually their last chance of survival.

People from black, Asian, and ethnic minority backgrounds have a 40% chance of finding a suitable bone marrow donor, compared with White northern Europeans, who have a 90% chance.

Donations usually take place during an outpatient appointment, in a procedure that is similar to donating blood.

You can join the bone marrow register here

Visit Tia's dedicated Facebook page here

Additional reporting by PA

PROMOTED VIDEO
Have you tried new the Independent Digital Edition apps?
News
ebookA unique anthology of reporting and analysis of a crucial period of history
News
peopleThe Game of Thrones author said speculation about his health and death was 'offensive'
News
Justin Bieber performing in Paris earlier this year
people
Arts and Entertainment
Martin Freeman and Lauren O'Neil in Jamie Lloyd's Richard III
theatreReview: The monarch's malign magnetism and diabolic effrontery aren’t felt
Arts and Entertainment
'Molecular Man +1+1+1' by Jonathan Borofsky at Yorkshire Sculpture park
tv
News
Glamour magazine hosts a yoga class with Yogalosophy author Mandy Ingber on June 10, 2013 in New York City.
newsFather Padraig O'Baoill said the exercise was 'unsavoury' in a weekly parish newsletter
Extras
indybest
News
people'She is unstoppable', says Jean Paul Gaultier at Paris show
Sport
Alexis Sanchez and apparently his barber Carlos Moles in Barcelona today
football
Arts and Entertainment
Miley Cyrus has her magic LSD brain stolen in this crazy video produced with The Flaming Lips
video
Arts and Entertainment
In his own words: Oscar Wilde in 1882
theatreNew play by the Oscar Wilde's grandson reveals what the Irish wit said at his trials - and what they reveal about the man
News
people
Arts and Entertainment
Unless films such as Guardians of the Galaxy, pictured, can buck the trend, this summer could be the first in 13 years that not a single Hollywood blockbuster takes $300m
filmWith US films earning record-breaking amounts at the Chinese box office, Hollywood is more than happy to take its lead from its new-found Asian audience
Independent
Travel Shop
the manor
Up to 70% off luxury travel
on city breaks Find out more
santorini
Up to 70% off luxury travel
on chic beach resorts Find out more
sardina foodie
Up to 70% off luxury travel
on country retreats Find out more
Have you tried new the Independent Digital Edition apps?
Independent Dating
and  

By clicking 'Search' you
are agreeing to our
Terms of Use.

iJobs Job Widget
iJobs General

Project Support Assistant - Hampshire - up to 40K

£25000 - £40000 per annum + 23 days holiday Pension Scheme: Deerfoot IT Resour...

Foundation / Year 1 Teacher - Long Term - Salford

£90 - £130 per day + competitive rates, pension scheme: Randstad Education Man...

.Net Developer -London - up to 55K

£45000 - £55000 per annum + Excellent benefits : Deerfoot IT Resources Limited...

Long Term Primary Teacher - Oldham - Start September 2014

£100 - £140 per day: Randstad Education Manchester Primary: Key Stage 1 Teache...

Day In a Page

The true Gaza back-story that the Israelis aren’t telling this week

The true Gaza back-story that the Israelis aren’t telling this week

A future Palestine state will have no borders and be an enclave within Israel, surrounded on all sides by Israeli-held territory, says Robert Fisk
A History of the First World War in 100 Moments: The German people demand an end to the fighting

A History of the First World War in 100 Moments

The German people demand an end to the fighting
New play by Oscar Wilde's grandson reveals what the Irish wit said at his trials

New play reveals what Oscar Wilde said at trials

For a century, what Wilde actually said at his trials was a mystery. But the recent discovery of shorthand notes changed that. Now his grandson Merlin Holland has turned them into a play
Can scientists save the world's sea life from

Can scientists save our sea life?

By the end of the century, the only living things left in our oceans could be plankton and jellyfish. Alex Renton meets the scientists who are trying to turn the tide
Richard III, Trafalgar Studios, review: Martin Freeman gives highly intelligent performance

Richard III review

Martin Freeman’s psychotic monarch is big on mockery but wanting in malice
Hollywood targets Asian audiences as US films enjoy record-breaking run at Chinese box office

Hollywood targets Asian audiences

The world's second biggest movie market is fast becoming the Hollywood studios' most crucial
Grindr founder Joel Simkhai: 'I've found love on my dating app - and my mum keeps trying to hook me up!'

Grindr founder Joel Simkhai: 'I've found love on my dating app'

Five years on from its launch and Grindr is the world's most popular dating app for gay men. Its founder Joel Simkhai answers his critics, describes his isolation as a child
Autocorrect has its uses but it can go rogue with embarrassing results - so is it time to ditch it?

Is it time to ditch autocorrect?

Matthew J X Malady persuaded friends to message manually instead, but failed to factor in fat fingers and drunk texting
10 best girls' summer dresses

Frock chick: 10 best girls' summer dresses

Get them ready for the holidays with these cool and pretty options 
Westminster’s dark secret: Adultery, homosexuality, sadomasochism and abuse of children were all seemingly lumped together

Westminster’s dark secret

Adultery, homosexuality, sadomasochism and abuse of children were all seemingly lumped together
A History of the First World War in 100 Moments: Dulce et decorum est - a life cut short for a poet whose work achieved immortality

A History of the First World War in 100 Moments

Dulce et decorum est: a life cut short for a poet whose work achieved immortality
Google tells popular music website to censor album cover art in 'sexually explicit content' ban

Naked censorship?

The strange case of Google, the music website and the nudity take-down requests
Howzat! 8 best cricket bats

Howzat! 8 best cricket bats

As England take on India at Trent Bridge, here is our pick of the high-performing bats to help you up your run-count this summer 
Brazil vs Germany World Cup 2014 comment: David Luiz falls from leader figure to symbol of national humiliation

David Luiz falls from leader figure to symbol of national humiliation

Captain appears to give up as shocking 7-1 World Cup semi-final defeat threatens ramifications in Brazil