The former Florida Governor has been doing the rounds in recent weeks, trying to get over his message on a variety of issues.
Ahead of the debate, the 62-year--old suggested he wanted to cut funding for women's health services and a group that found itself at the centre of controversy over a 'sting' video.
Speaking to 13,000 pastors at the Southern Baptist Forum in Nashville, Tennessee, Mr Bush said he supported cutting federal funds for Planned Parenthood, the largest women's health service provider in the US.
"The next president should defund Planned Parenthood," he said. "You could take dollar for dollar - although I'm not sure we need a half-billion dollars for women's health issues - but if you took dollar for dollar, there are many extraordinary fine community health organizations that exist to provide quality care for women on a wide variety of health issues."
Mr Bush supports the Pain-Capable Unborn Child Protection Act which would ban abortion after 20 weeks, making exceptions for the life of the mother, rape or incest. During the same speech to the Southern Baptist Forum he said: "Abortion should not be funded by the government."
Mr Bush support creating a legal status - but not a path to citizenship - for undocumented residents. He wants to limit family-related legal immigration but increase the number of migrants who have specific skills. Mr Bush, whose wife is a naturalised immigrant, told the Club for Growth in February that to gain legal status, undocumented immigrants should pay fines, file taxes and learn English.