Hussey struck a career-best unbeaten 232 from 298 balls yesterday with 22 fours and six sixes to help the hosts post 514 all out in their first innings.
The 28-year-old started slowly but accelerated his rate of scoring once he was batting with the tail. It was a remarkable recovery as Nottinghamshire had been 75 for 4 at one stage, but they finished day two with a 358-run lead - taking three Warwickshire second-innings wickets in the final session.
Warwickshire, who were skittled out for 156 in their first innings, lost Ian Westwood, Jonathan Trott and Luke Parker before they close. They will resume today on 107 for 3, still 251 runs behind.
Dinesh Mongia's brilliant 164 was the highlight as Leicestershire and Durham settled for a draw in their Second Division match at the Riverside.
The Indian left-hander built on his overnight 77 and had hit 26 fours and three sixes in his innings before being stumped in the over before lunch.
Leicestershire batted on until they were all out for 443, a first-innings lead of 128, but with 43 overs to survive on a placid pitch, Durham reached 103 for 2 before a halt was called at 5.30pm.Reuse content