Tranmere staged a grandstand second half fightback in a game which really came to life with three goals in four minutes but they were left still seeking their first league victory.
Marcus Stewart fired Huddersfield in front in the 20th minute and the visitors increased their lead on the stroke of half-time as Wayne Allison powered home a header from a Rob Edwards' corner.
Tranmere pulled one back through Andy Parkinson, but Edwards again set Allison up for his second goal of the night after 68 minutes. Jason Koumas pulled it back to 3-2 but it was not enough to save the home side.
Wolverhampton Wanderers may have lost their unbeaten record against Port Vale on Tuesday but Mark McGhee, their manager, refuses to give up on the side which has emerged as early promotion contenders.
Wolves entertain their fellow pace-setters Sunderland today with many options available but McGhee is banking on his present selection. "I am still convinced that this is my best team and that there is no-one I can bring in at the moment to improve things," he said.Reuse content