Chelsea manager Carlo Ancelotti is determined to improve on last season's performance in the Champions League which saw his side go out in the last-16 stage.
However the Italian intends to rest a number of players against a MSK Zilina of Slovakia on Wednesday while Didier Drogba is suspended.
Champions Chelsea go into the match full of confidence after their fourth successive league win - a 3-1 victory over rock-bottom West Ham.
Ancelotti said: "I will change the line-up because I want to rest players. I don't want to think the Champions League is more important than the Premier League.
"The normal step is to want to do better in the Champions League. We went out too early and want to do better this season."
Manchester United face Rangers tomorrow on the back of dropping two points against Everton after conceding two goals in injury time.
Midfielder Darren Fletcher accepts they have lessons to learn following the 3-3 draw at Goodison Park.
The result followed a similar performance at Fulham and Fletcher said: "We really have to learn from this game if we want to take it forward this season and win the league."
Arsene Wenger is in no doubt there will be plenty more goals to come from his Arsenal team, who face Braga in the Champions League on Wednesday.
The Gunners chalked up their 1,000th Premier League goal under Wenger during the 4-1 win over Bolton.
"We know we can score goals and as a team we improve from season to season," said the Arsenal boss. "We are more mature, and of course our challenge will be to be sound at the back."
Tottenham take on Werder Bremen tomorrow with manager Harry Redknapp boosted by the news Luka Modric's injury is not as first feared.
Modric left Spurs' 1-1 draw with West Brom on crutches after a challenge with defender Gonzalo Jara, but scans yesterday cleared the midfielder of a broken leg and he will travel to Germany.
Redknapp said: "Modric makes a difference. In my opinion, he could play in any team, anywhere in the world."
Fulham striker Bobby Zamora has been ruled out for four months after breaking his right ankle in the 2-1 victory over Wolves.
The 29-year-old is having surgery and faces a longer lay-off if further damage is discovered.
Fulham overcame his first-half departure to complete a last-gasp comeback victory sealed by Moussa Dembele's first Barclays Premier League goals.
Two teams with ambitions of breaking into the Champions League had to settle for a point over the weekend.
Manchester City drew 1-1 with Blackburn while Liverpool were held to a goal-less draw by Birmingham.
However Blackpool are flying high after their surprise promotion and chalked up a 2-0 victory against Newcastle while Wigan and Sunderland finished all-square at 1-1.