Most of the focus is on Anfield where Brendan Rodgers' side must beat Basel if they are to progress to the knock-out phase of the competition. A draw or defeat is not an option.
Arsenal have already qualified, but Arsene Wenger's stuttering team can still top their group with victory.
Click here for an explainer to all tonight's groups and what each team must do to progress.
Other teams in action this evening include Atletico Madrid, Juventus, Real Madrid, Monaco and Borussia Dortmund. You can follow live scores from all the matches below.
We'll also be bringing you Twitter updates on the key events of the evening...
Tweets by @IndyFootball
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