Tottenham v Wisla Krakow
Luka Modric has a knee injury and will miss Tottenham's Uefa Cup game against Wisla Krakow tonight at White Hart Lane.
Vedran Corluka and Roman Pavlyuchenko are cup-tied, meaning striker Fraizer Campbell, who is on loan from Manchester United, could make his club debut. Alan Hutton (foot) is ruled out but captain Ledley King could return after being rested for the defeat to Aston Villa on Monday.
Manager Juande Ramos said: "It's essential we get that first win. I've every trust in the squad that they will do it but they have to prove it to everyone."
Tottenham (from): Gomes, Sanchez, Zokora, Gunter, Bale, Assou-Ekotto, Gilberto, King, Woodgate, Dawson, Bentley, Jenas, Huddlestone, Taarabt, O'Hara, Lennon, Boateng, Dos Santos, Bent, Campbell.
Everton v Standard Liège
Leon Osman could return for Everton against Belgians Standard Liège. The midfielder has been rated as 50/50 and will undergo a fitness test on his knee injury before the match.
New team-mate Marouane Fellaini is cup-tied for this match after playing for Liège in their Champions League qualifier against Liverpool last month.
Steven Pienaar (ankle), Andy van der Meyde (hamstring), Tony Hibbert (cruciate knee ligament), Joseph Yobo (ankle) and Louis Saha (calf) all still require further treatment and are unavailable.
Everton (from): Howard, Neville, Lescott, Baines, Jagielka, Arteta, Osman, Cahill, Baxter, Yakubu, Turner, Nash, Jutkiewicz, Agard, Kissock, Wallace.
Omonia Nicosia v Manchester City
Martin Petrov has been ruled out of Manchester City's match against Omonia Nicosia. The Bulgarian winger has failed to recover from a knee injury in time for the first leg game and is staying at home to receive further treatment.
Michael Johnson, who has signed a new five-year contract, remains doubtful with a groin problem but travelled to Cyprus with the rest of the squad today.
City's record £32.5m signing Robinho was also in the party after making his debut in the defeat by Chelsea at the weekend.
Manchester City (from): Hart, Richards, Ball, Johnson, Ireland, Wright-Phillips, Robinho, Elano, Jo, Garrido, Schmeichel, Fernandez, Hamann, Dunn, Evans, Ben Haim, Sturridge, Etuhu, Kompany, Zabaleta, Glauber.
Portsmouth v Guimaraes
John Utaka is a fitness doubt to face Portugal's Guimaraes at Fratton Park. Utaka damaged a knee in training yesterday and faces a late fitness test with Glen Little, who has yet to appear in a match since his summer move from Reading, is standing by after coming through a reserve game to test a thigh injury.
Manager Harry Redknapp has excluded striker David Nugent and former Arsenal defender Lauren from his European squad, admitting that when he had to submit his list of names last month he expected the pair to be sold in the transfer window.
Portsmouth (from): James, Johnson, Campbell, Distin, Belhadj, Utaka, Little, Diarra, Davis, A Traoré, Crouch, Defoe, Diop, Kaboul, Kanu, Hughes, Wilson, Ritchie, Pamarot, Hreidarsson, Mvuemba, Ashdown.
Litex Lovech v Aston Villa
Aston Villa will have to make at least one change for their tie against Litex Lovech in Bulgaria. Norway striker John Carew did not travel with the rest of the squad as he recovers from the ankle injury he picked up in Monday's win at Tottenham.
Marlon Harewood will come into contention for the first-leg match, while James Milner could start for the first time since his £12m move from Newcastle.
Manager Martin O'Neill may opt to hand a debut to Spanish defender Carlos Cuellar in what is a busy time for the Midlands club.
Aston Villa (from): Friedel, L Young, Laursen, Davies, Cuellar, Knight, Shorey, Milner, Barry, Reo-Coker, Salifou, A Young, Petrov, Gardner, Osbourne, Routledge, Agbonlahor, Harewood, Delfouneso, Guzan, Taylor.
Nancy v Motherwell
Motherwell will make their first appearance in Europe since 1995 against Nancy with manager Mark McGhee insisting his side will not be overawed by the experience.
"All the boys in the team, whether they've played in Europe or not, are hungry for the experience," McGhee said. "Everyone wants to experience what European football has to offer. We've got an honest bunch here who are anticipating the trip with relish."
McGhee is not expected to make many changes to the side beaten 4-2 by Celtic on Saturday despite admitting his side were outplayed.
Motherwell (from): G Smith,Quinn, Craigan, Reynolds, Hammell, Hughes, Lasley, McGarry, Clarkson, Porter, O'Brien, Murphy, Sutton, Nielsen,Malcolm, D Smith, Fitzpatrick, Connolly.