Wolves were pushed closer to relegation from the Championship when Danny Ings' left-foot strike and Martin Paterson's close-range goal saw Burnley win 2-1 at Molineux despite the dismissal of Clarets' Michael Duff just after the hour.
Defeat sparked a pitch invasion by Wolves fans, who seemed to jostle defender Roger Johnson, and a protest outside the ground calling for owner, Steve Morgan, and chief executive, Jez Moxey, to go.
"I am devastated," Wolves manager, Dean Saunders, said. "We should never be in the position we are in. We are not dead yet. Obviously it is stacked up against us but stranger things have happened. It was in our own hands before this game but we let in two terrible goals."
Saunders's side, who will pass his former club, League One champions Doncaster, now face a double-dip relegation having dropped out of the Premier last May. They will become the first club to have fallen twice from the top flight to the third tier in two seasons, having done likewise in the mid 1980s. Next Saturday Wolves go to play-off bound Brighton, who won a feisty match 2-1 at Elland Road where Leeds ended with nine men (Rodolph Austin and El Hadji Diouf saw straight reds) and Brighton with 10 (Will Buckley).
The win sealed Seagulls' play-off place, but Crystal Palace and Bolton, who drew 1-1 at Blackburn and Champions Cardiff respectively, can be caught by Nottingham Forest, who won 1-0 at Millwall, and Leicester.
A David Vaughan hat-trick saw Huddersfield win 3-1 at Bristol City all but seal their survival.
In League One, despite beating Swindon Town 3-1, Scunthorpe United were relegated because Colchester won 2-0 at Carlisle.
Passing the Iron in the opposite direction will be Rotherham, who beat relegated Aldershot 2-0, and Port Vale, who earned the point needed for promotion with a 1-1 draw at Wycombe.
Where they stand
League One Doncaster Rovers and Bournemouth are promoted. Play-off semi-final first legs: Sheffield Utd v Yeovil (Fri 3 May), Swindon v Brentford (Sat 4 May). Second legs: Brentford v Swindon, Yeovil v Sheffield Utd (Mon 6 May).
League Two Gillingham, Port Vale and Rotherham are promoted. Play-off semi-final first legs: Bradford v Burton, Northampton v Cheltenham (Thurs 2 May). Second legs: Burton v Bradford, Cheltenham v Northampton (Sun 5 May)
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