Liverpool striker Christian Benteke could be in line to feature in the 225th Merseyside derby at Goodison Park if he passes a late fitness test.
The Belgian frontman has missed the last three matches with a hamstring injury sustained during the 1-1 draw with Norwich City but a decision on his return is set to be made within the next 24 hours.
Dejan Lovren and Roberto Firmino will miss the clash with Roberto Martinez's Everton with ankle and back injuries respectively, although both are expected to return later this month.
Captain Jordan Henderson will also be absent with a long-term foot fracture expected to keep him out until mid-November.
Young full-back Jon Flanagan is not expected to have fully recovered from his serious knee injury until December at the earliest.
Manager Brendan Rodgers is expected to name his strongest line-up, having rested seven first-team players for Thursday's Europa League group stage meeting with FC Sion.
Daniel Sturridge, who was left out in mid-week as a precaution, is expected to return up front alongside Danny Ings.
Christian Benteke - hamstring injury - potential return 4th October
Roberto Firmino - back injury - expected back 17 October
Dejan Lovren - ankle/foot injury - expected back 22 October
Jordan Henderson - foot injury - expected back 21 November
Jon Flanagan - knee injury - expected back 15 December
Mignolet, Can, Skrtel, Sakho, Clyne, Milner, Lucas, Moreno, Coutinho, Sturridge, Ings, Bogdan, Toure, Gomez, Allen, Rossiter, Ibe, Lallana, Benteke, OrigiReuse content