Tottenham can move four points ahead of Arsenal in the Premier League table with a win at Emirates Stadium on Saturday.
Spurs, who have not finished above Arsenal since 1994/95, are seventh on 17 points and lead the eighth-placed Gunners by a point after Arsene Wenger's side were held to a 3-3 draw by Fulham last weekend.
Andre Villas-Boas' squad have lost their past two league matches since beating Southampton 2-1 in October - they went down to Manchester City 2-1 on Sunday and were beaten 1-0 by Wigan on November 3.
Arsenal face Tottenham for the first time since coming from two goals behind to rout Spurs 5-2 in February, but have had their own struggles this season - winning just four games out of 11 in the Premier League.
Oliver Giroud scored twice for Arsenal in their match against Fulham and will be looking to back up his performance in his first North London Derby this weekend.
KICK-OFF: Saturday, 12.45pm
PAST THREE MEETINGS…
Arsenal 5 (Sagna, van Persie, Rosicky, Walcott 2) Tottenham 2 (Saha, Adebayor), Premier League, February 2012
Tottenham 2 (van der Vaart, Walker) Arsenal 1 (Ramsey), Premier League, October 2011
Tottenham 3 (van der Vaart 2, Huddlestone) Arsenal 3 (van Persie, Nasri, Walcott), Premier League, April 2011
A two-goal lead has been squandered in three of the last four games between these two sides.
The last five meetings between the sides at Arsenal's home ground have seen 26 goals scored - 16 by the Gunners and 10 by Spurs.
Tottenham are one win away from 300 in the Premier League.
Arsenal to win: 1.90
Tottenham to win: 3.60
TV: Live on Sky Sports 2 at 12.45 and highlights on BBC1 at 10.30pm