Manchester City top scorer Sergio Aguero is expected to be out for a month with a hamstring injury, manager Manuel Pellegrini has announced.
The Argentina striker hobbled off during City's 5-1 Barclays Premier League win at Tottenham on Wednesday.
Pellegrini said: "The doctor is seeing him - maybe one month, but we are not sure absolutely."
The injury will rule Aguero, who has scored 26 goals this season, out of the first leg of City's Champions League last-16 tie against Barcelona as well as Premier League and FA Cup games against Chelsea.
The game at White Hart Lane had been Aguero's fifth since returning from a month-long lay-off with a calf injury.
Yet with City having scored 115 goals in all competitions this term, Pellegrini is confident his team can overcome his absence.
He said: "It is very difficult. Sergio is a top player for us but I think we can replace him.
"As with the other injury, we hope we can continue to do it.
"But, of course, he is a very important player for us.
"Sergio is just coming back from an injury - one month that he couldn't play.
"All the other strikers, Alvaro Negredo, Edin Dzeko and now Stevan Jovetic, replace him."