Carlos Tevez faces a race against time to be fit for next weekend's Manchester derby.
The Argentina star tweaked his knee during World Cup duty with his country last weekend and has already been ruled out of Manchester City's clash with Arsenal tomorrow.
Early indications are Tevez will also sit out the Old Trafford encounter with United on September 20.
Tevez is desperate to play against his former club, having assumed cult hero status at City due to his bitter departure from United.
And Hughes will give the South American every opportunity.
"The Argentine medical people said it would be two or three weeks," said the City boss.
"We think it might be less than that but he is a doubt for the derby next week.
"However, we will do everything in our power to get him fit because, for obvious reasons, he would love to play in that match."
Meanwhile, City will wait for the results of scans on Robinho's ankle injury before deciding whether the Brazilian will face the Gunners.
"He had a little bit of swelling on the ankle," confirmed Hughes.
"We do not think there is a significant injury there but it is best to check to make sure there is no stress fracture.
"Once we get the results we can decide whether he plays tomorrow or not."