Harry Redknapp returns to White Hart Lane for the first time since he was sacked as manager in 2012 and has opted to start Loic Remy in attack.
The French striker has been linked with an exit all summer, with Spurs among those reportedly interested. Today he'll get a chance to show them what they would be getting.
Rio Ferdinand and Steven Caulker - who started his career at Spurs - start together at the back for the visitors with Joey Barton in midfield. Former Tottenham striker Bobby Zamora has to make do with a place on the bench.
The home side have Erik Lamela in the starting line-up and will be hoping he can follow up his impressive performance in the Europa League in midweek with another.
Eric Dier, who scored the winner against West Ham last weekend is in the starting line-up whilst Emmanuel Adebayor will be the focal point of the attack.
Tottenham Hotspur: Lloris, Dier, Kaboul, Vertonghen, Rose, Capoue, Bentaleb, Lamela, Eriksen, Chadli, Adebayor.
Subs: Lennon, Soldado, Holtby, Kane, Dembele, Friedel, Davies.
QPR: Green, Dunne, Ferdinand, Caulker, Phillips, Isla, Barton, Fer, Traore, Mutch, Remy.
Subs: Simpson, Wright-Phillips, Onuoha, Faurlin, Murphy, Hoilett, Zamora.
Referee: Anthony Taylor (Cheshire)