Nick Conway played an influential role scoring twice in the first 12 minutes, winning a tackle to set up Phil McGuire for a superb third and then releasing Jon Hauck, whose progress was stopped at the expense of a stroke which was converted by McGuire.
Danny Hall pulled one back in a rare second-half Guildford attack, but Andrew Billson replied immediately.
Cannock slipped off the top as a result of their 2-1 defeat by Hounslow, whose goals came from a penalty stroke by Mike Williamson and a sweetly dragged penalty corner by Will Nurse.
Paul Edwards hit the post from a penalty stroke before Simon Organ created the opening for Ben Sharpe to pull one back in the penultimate minute.
There was a hat-trick for Rowan Davis in Southgate's 4-4 draw with Canterbury and for Richard Gibson, of East Grinstead, which were not enough to stop Havant winning 4-3.
In the first division, Beeston increased their lead to nine points by beating nearest rivals Doncaster 4-2.Reuse content