"I think for both teams, after losing the opening game, you have to show that you can come back immediately and win the next fixture," Rangers' manager, Walter Smith, said. "Psychologically a win would work wonders for us."
Juventus are odds-on favourites to head Group C, having already won 3- 1 in Dortmund, leaving the Germans, Rangers and Romania's Steaua Bucharest to chase the other quarter-final place.
Smith has a problem in defence with centre-back Alan McLaren suspended after being sent off during the 1-0 defeat by Steaua in Bucharest, and Richard Gough and David Robertson are doubtful. Rangers do have Stuart McCall and Ian Ferguson available again after lengthy absences.
Standing by for defensive places are Alex Cleland, Gary Bollan and Brian Reid while McCall - out for five games - might be a candidate for right- back or midfield.
The fitness of Gough and Robertson will determine whether Rangers stick with 5-3-2 or revert to 4-3-3, although the three foreigners look certain to be Paul Gascoigne, Brian Laudrup and Gordan Petric.
Dortmund, without strikers Stephane Chapuisat and Karlheinz Riedle, have doubts over the German international Matthias Sammer. They will lean heavily on Andreas Moller, with the Uruguayan Ruben Sosa likely to be left out.