Hamilton, a 23-year-old from Nottingham, reached the last 16 of the Regal Welsh Open with a 5-3 victory over the sixth seed, Alan McManus.
It was another accomplished display from Hamilton, who has yet to fulfil his potential despite being a professional since 1991.
Hamilton made a 145 total clearance in the World Championship qualifying rounds at Blackpool last week and, in beating Mark Bennett 5-3 in the first round of the Welsh Open, he fired in breaks of 127 and 134.
Hamilton, the world No 35, took the second frame with a 136 break, the fourth with a 122 and the eighth after runs of 61 and 65.
McManus, who defends his Benson and Hedges Masters title at Wembley early next month, added: "It's one of those matches I just wish I could play again."
Darren Morgan joined the list of unexpected losers when he was beaten 5-3 John Read, the world No 87.
"John didn't beat me, I beat myself," Morgan said. "At the moment you could put Donald Duck up against me and he'd have a good chance."
Willie Thorne, the 15th seed, became the 10th player from the top 16 to be eliminated when he lost 5-4 to Cardiff's Paul Davies.Reuse content