Arts and Entertainment Jared Leto in 'Dallas Buyers Club'

When will TV and film start opening the door to transgender actors, asks Paris Lees

William Roache, child abuse and past lives

Judging by his comments, I guess my disability is just a punishment for being a total badass in a previous life?

Saul Sanchez, 48: “He is a very simple man. You know it because he liked to come here and just be with us. He is just a normal person who would eat and drink with us”

'The Slum Pope? He is bigger than that – he is for all the poor people'

Before becoming Pope, Jorge Mario Bergoglio won the hearts of the slum people ministering to the poor and sick

Signs of a rethink on America's War on Drugs

Maryland looks likely to follow Washington and decriminalise marijuana

HIV drugs could 'functionally cure' about 10% of early diagnosed patients

Breakthrough follows reports of a baby girl in the US who was 'cured' after very early treatment

Editorial: A baby step forward in the fight against Aids

HIV/Aids has proved a stubborn problem. Thirty years on from the discovery of the virus – after tens of millions of deaths – there is still only one recorded case of an adult sufferer being cured. (The so-called "Berlin patient" had his entire immune system replaced with that from someone resistant to the disease.)

'Cured' baby remains solitary reminder that genuine solution to HIV is still a long way off

This year marks the 30th anniversary of the discovery of the human immunodeficiency virus (HIV), so it is with great excitement that the Aids community has received the news that a baby has been “cured” of the virus.

Doctor C Everett Koop: Surgeon General who angered US conservatives with his stance on abortion and Aids

Doctor C Everett Koop: Surgeon General who angered US conservatives with his stance on abortion and Aids

Dr C Everett Koop, who died on 25 February at the age of 96, was a leading US health official throughout much of the 1980s who spoke frankly about Aids and railed against smoking. An evangelical Christian, Koop shocked his conservative supporters when he endorsed condoms and sex education to stop the spread of Aids. He was surgeon general for seven years during the Ronald Reagan and George HW Bush administrations. He carried out a crusade to end smoking in the US.

Poverty and poor sanitation are key factors in the spread of the disease

Bill Gates: We cannot stand still on polio, but we can push ahead and end it

Through its judicious use of foreign aid, the UK has helped drive this recent progress

Man charged with murder of gay mayoral candidate

A man has been charged with the murder of an openly gay candidate for mayor of a Mississippi town.

Elton John finds second baby 'much easier' than first

David Furnish has told how he and partner Sir Elton John have found parenthood much easier the second time around.

A couple kisses in Times Square, New York

'Severe epidemic' of sexually transmitted diseases sweeping the US, warn health experts in Valentine’s Day announcement

Centers for Disease Control and Prevention says 20 million new STD cases are diagnosed every year

The ‘Love Is In My Blood’ campaign involves Twitter messages and a video in Piccadilly Circus

Elton John and Ai Weiwei join forces to launch Valentine's Day Aids campaign

Sir Elton John and the Chinese artist Ai Weiwei will today join forces to support a Valentine's Day campaign to raise awareness of Aids.

It was not widely known Mike Freer, a Tory MP, was gay

Mike Freer: A gay Tory MP on why he went public

Mike Freer hesitated for a long time over whether to say anything at all when his fellow MPs argued over whether to legalise gay marriage. He is one of the newer MPs and it was not widely known in Parliament that he is gay.

'Unsafe sexual behaviour' leaves HIV levels among gay men unchanged, says report

“Unsafe sexual behaviour” and a lack of testing is being blamed for a failure to cut the number of cases of HIV among gay and bisexual men in the last decade.

Pop star Madonna cuts the ribbon at the ground breaking ceremony for the Raising Malawi Academy for Girls in Malawi in 2009

Madonna's charitable endeavours rubbished by Malawi education authorities

Madonna’s charitable endeavours were dealt another blow when Malawi’s Education Minister flatly denied the pop star’s claims that her charity had built 10 new schools in the country.

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Pompeii, Capri & the Bay of Naples
Seven Cities of Italy
Burgundy, the River Rhone & Provence
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Lake Garda
Minoan Crete and Santorini
Prices correct as of 15 May 2015
How to stop an asteroid hitting Earth: Would people co-operate to face down a global peril?

How to stop an asteroid hitting Earth

Would people cooperate to face a global peril?
Just one day to find €1.6bn: Greece edges nearer euro exit

One day to find €1.6bn

Greece is edging inexorably towards an exit from the euro
New 'Iron Man' augmented reality technology could help surgeons and firefighters, say scientists

'Iron Man' augmented reality technology could become reality

Holographic projections would provide extra information on objects in a person's visual field in real time
Sugary drinks 'are killing 184,000 adults around the world every year'

Sugary drinks are killing 184,000 adults around the world every year

The drinks that should be eliminated from people's diets
Pride of Place: Historians map out untold LGBT histories of locations throughout UK

Historians map out untold LGBT histories

Public are being asked to help improve the map
Lionel, Patti, Burt and The Who rock Glasto

Lionel, Patti, Burt and The Who rock Glasto

This was the year of 24-carat Golden Oldies
Paris Fashion Week

Paris Fashion Week

Thom Browne's scarecrows offer a rare beacon in commercial offerings
A year of the caliphate:

Isis, a year of the caliphate

Who can defeat the so-called 'Islamic State' – and how?
Marks and Spencer: Can a new team of designers put the spark back into the high-street brand?

Marks and Spencer

Can a new team of designers put the spark back into the high-street brand?
'We haven't invaded France': Italy's Prime Minister 'reclaims' Europe's highest peak

'We haven't invaded France'

Italy's Prime Minister 'reclaims' Europe's highest peak
Isis in Kobani: Why we ignore the worst of the massacres

Why do we ignore the worst of the massacres?

The West’s determination not to offend its Sunni allies helps Isis and puts us all at risk, says Patrick Cockburn
7/7 bombings 10 years on: Four emergency workers who saved lives recall the shocking day that 52 people were killed

Remembering 7/7 ten years on

Four emergency workers recall their memories of that day – and reveal how it's affected them ever since
Humans: Are the scientists developing robots in danger of replicating the hit Channel 4 drama?

They’re here to help

We want robots to do our drudge work, and to look enough like us for comfort. But are the scientists developing artificial intelligence in danger of replicating the TV drama Humans?
Time to lay these myths about the Deep South to rest

Time to lay these myths about the Deep South to rest

'Heritage' is a loaded word in the Dixie, but the Charleston killings show how dangerous it is to cling to a deadly past, says Rupert Cornwell
What exactly does 'one' mean? Court of Appeal passes judgement on thorny mathematical issue

What exactly does 'one' mean?

Court of Appeal passes judgement on thorny mathematical issue