Arts and Entertainment Jared Leto in 'Dallas Buyers Club'

When will TV and film start opening the door to transgender actors, asks Paris Lees

The moai, giant stone statues that line the Easter Island coast

This week's big questions: Can ancient tribes teach us anything? Are we doomed, like Easter Islanders, to extinction?

This week's questions are answered by Jared Diamond, an American scientist and the author of the bestselling ‘Guns, Germs, and Steel

Spencer Cox: Activist who helped bring an anti-Aids drug on to the market

Spencer Cox, who died in New York of Aids-related causes on 18 December aged 44, was an Aids activist who helped form an organisation to boost treatment research and recently appeared in a documentary about an Aids coalition.

Kenneth Kendall: Much-loved newsreader who became the first to be seen on screen

When, on 4 September 1955, Kenneth Kendall became the first newscaster to appear on a British television screen in the flesh, it was the culmination of years of debate at the BBC – at first over whether it was right to broadcast news on television at all, and then whether images of any kind might distort the message.

Martin Richards: Producer

Martin Richards, who died of cancer on 26 November at the age of 80, was the producer of the original Chicago on Broadway and went on to win an Academy Award for producing the film version. He was also the Tony Award-winning producer behind such Broadway hits as Sweeney Todd and The Will Rogers Follies. His other films included The Shining, Boys From Brazil and Fort Apache, The Bronx.

Anne Hathaway has tried extreme – and extremely unpleasant – eating regimes to lose weight for a part

Hollywood roles to diet for

If you find it hard to lose weight, be glad you're not an actor. Playing an emaciated waif can mean mad, bad and dangerous eating plans, says Gillian Orr

Books of the Year 2012: Celebrity

From art to sport, poetry to nature, travel to food, history to music: our writers select the best of the year’s books in a comprehensive guide to the highlights in every shade of the literary spectrum – except grey

World AIDS Day: Health problems do not discriminate based on where people live

It's not just low income countries that have a problem.

Editorial: Aids treatment is a success story, but more must be done

In 2000, a year's course of anti-retroviral drugs cost $10,000 and projections caused consternation even in Western countries coping with a few thousand cases of HIV. The idea that treatment might be rolled out to millions in the developing world seemed a pipe dream.

Elderly women in Kasarika, a village with one of the highest rates of HIV in Malawi

World Aids Day: The curse of being one of the witches of Malawi

An Aids awareness scheme is teaching villagers HIV is an illness, and not caused by witchcraft. By Hazel Southam in Kasarika

A torch light rally is held in Kolkata yesterday ahead of World Aids Day

World Aids Day: ‘Turning the tide will fail if funding is not increased’

Three decades on from the start of the Aids pandemic, the main global agencies are uncertain whether to be cheerful or gloomy about prospects for the worst disease of modern times .

Patient co-ordinator Chris is one of the longest living survivors of HIV in Britain

World Aids Day: Suddenly I had a future, the relief was immense

Patient co-ordinator Chris is one of the longest living survivors of HIV in Britain. He speaks to Patrick Strudwick

World AIDS Day: A race against time as HIV treatment is cut

Anti-retrovirals are vital in improving and saving the lives of children with HIV.

The Vivisector: Group show curated by Todd Levin, Sprüth Magers, London

A naked doll with long synthetic hair greets the visitor to this inspired exhibition, which explores "the idea of opening up and exposing a living body".

HIV is still a red-hot issue in the UK

The red ribbon is the universal symbol of awareness and support for those living with HIV. This year marks the 25th anniversary of the National Aids Trust (NAT), the UK's leading charity dedicated to transforming society's response to HIV. In honour of the occasion, a number of NAT's high-profile supporters have created exclusive pieces of red-ribbon art.

Inquires into Yasser Arafat's death will lead to the exhumation of his body on late November

Arafat's remains to be exhumed in Ramallah on Tuesday

The remains of former Palestinian leader Yasser Arafat will be exhumed on Tuesday as part of a renewed investigation into his death, a Palestinian investigator said.

Life and Style
A monstrous idea? Body transplants might no longer be science fiction
Science An Italian neurosurgeon believes so - and it's not quite as implausible as it sounds, says Steve Connor
Demba Ba (right) celebrates after Besiktas win on penalties
footballThere was no happy return to the Ataturk Stadium, where the Reds famously won Champions League
Arts and Entertainment
Natural beauty: Aidan Turner stars in the new series of Poldark
arts + ents
Mia Freedman, editorial director of the Mamamia website, reads out a tweet she was sent.
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The write stuff: masters of story-telling James Joyce, left, and Thomas Hardy
arts + ents...begging to differ, John Walsh can't even begin to number the ways
Jose Mourinho on Sky Sports
footballEXCLUSIVE COLUMN Paul Scholes: It was not a leg-breaking tackle, as the Chelsea manager had claimed
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Day In a Page

Independent Travel
Pompeii, Capri & the Bay of Naples
Seven Cities of Italy
Burgundy, the River Rhone & Provence
Prague, Budapest and Vienna
Lake Garda
3.	Provence 6 nights B&B by train from £599pp
Prices correct as of 20 February 2015
HIV pill: Scientists hail discovery of 'game-changer' that cuts the risk of infection among gay men by 86%

Scientists hail daily pill that protects against HIV infection

Breakthrough in battle against global scourge – but will the NHS pay for it?
How we must adjust our lifestyles to nature: Welcome to the 'Anthropocene', the human epoch

Time to play God

Welcome to the 'Anthropocene', the human epoch where we may need to redefine nature itself
MacGyver returns, but with a difference: Handyman hero of classic 1980s TV series to be recast as a woman

MacGyver returns, but with a difference

Handyman hero of classic 1980s TV series to be recast as a woman
Tunnel renaissance: Why cities are hiding roads down in the ground

Tunnel renaissance

Why cities are hiding roads underground
'Backstreet Boys - Show 'Em What You're Made Of': An affectionate look at five middle-aged men

Boys to men

The Backstreet Boys might be middle-aged, married and have dodgy knees, but a heartfelt documentary reveals they’re not going gently into pop’s good night
Crufts 2015: Should foreign dogs be allowed to compete?

Crufts 2015

Should foreign dogs be allowed to compete?
10 best projectors

How to make your home cinema more cinematic: 10 best projectors

Want to recreate the big-screen experience in your sitting room? IndyBest sizes up gadgets to form your film-watching
Manchester City 1 Barcelona 2 player ratings: Luis Suarez? Lionel Messi? Joe Hart? Who was the star man?

Manchester City vs Barcelona player ratings

Luis Suarez? Lionel Messi? Joe Hart? Who was the star man at the Etihad?
Arsenal vs Monaco: Monaco - the making of Gunners' manager Arsene Wenger

Monaco: the making of Wenger

Jack Pitt-Brooke speaks to former players and learns the Frenchman’s man-management has always been one of his best skills
Cricket World Cup 2015: Chris Gayle - the West Indies' enigma lives up to his reputation

Chris Gayle: The West Indies' enigma

Some said the game's eternal rebel was washed up. As ever, he proved he writes the scripts by producing a blistering World Cup innings
In Ukraine a dark world of hybrid warfare and murky loyalties prevails

In Ukraine a dark world of hybrid warfare

This war in the shadows has been going on since the fall of Mr Yanukovych
'Birdman' and 'Bullets Over Broadway': Homage or plagiarism?

Homage or plagiarism?

'Birdman' shares much DNA with Woody Allen's 'Bullets Over Broadway'
Broadchurch ends as damp squib not even David Tennant can revive

A damp squib not even David Tennant can revive

Broadchurch, Series 2 finale, review
A Koi carp breeding pond, wall-mounted iPads and a bathroom with a 'wellness' shower: inside the mansion of Germany's 'Bishop of Bling'

Inside the mansion of Germany's 'Bishop of Bling'

A Koi carp breeding pond, wall-mounted iPads and a bathroom with a 'wellness' shower