News The eye of the storm: Speakes in the White House in 1982

An assassination attempt plunged Larry Speakes into the brightest of national spotlights as chief spokesman for President Ronald Reagan. When Reagan’s press secretary James Brady was severely wounded in the 1981 attempt on the president’s life, Speakes was thrust into the eye of the storm. As White House spokesman for six years, a long tenure in the sensitive post, he was credited with 2,000 news media briefings.

Merrill Lynch delays Manhattan building project

The credit market crisis is forcing Wall Street firms to rip up even some of their best-laid plans, the latest example being Merrill Lynch's decision to postpone the building of a hi-tech skyscraper in midtown Manhattan.

AstraZeneca closes in on £600m deal for CAT

Cambridge Antibody Technology (CAT) is set to become the latest biotech group to lose its independence, selling out to AstraZeneca in a deal worth about £600m.

Boots blames rising interest rates for slowdown in sales

Boots sent the first signal that the retail sector had failed to bounce back after a disappointing Christmas yesterday with a profit warning that knocked 4 per cent off its share price. Just six weeks after reassuring the City that profits to the end of March were on track, the group admitted its sales growth had dried amid a wider slowdown on the high street.

Market Report: Amvescap investors make a dash for the exit

Investors scrambled to exit Amvescap yesterday amid growing worry that next week's third-quarter results from the fund management giant are set to disappoint. The latest anxiety to surround the company was caused by a note from Merrill Lynch in which the broker slashed its earnings forecasts for Amvescap. Merrill cut its estimates by 4 per cent for the current year and 9 per cent for 2005, sending shares in the fund manager tumbling 11p to 280.5p.

Banker in sex-bias case denies she was 'pampered princess'

A senior banker suing Merrill Lynch in a multimillion-pound sex discrimination case denied yesterday that she was "a pampered princess".

Market Report: 'Sell' note puts pressure on Bradford & Bingley

Merrill Lynch certainly did not pull any punches in its investment note on Bradford & Bingleyyesterday. It bluntly told investors to sell the stock and set a fair value target of 254p.

Market Report: Broker soothes fears over Kingfisher's Easter

Worries about trading at Kingfisher during the all-important Easter weekend have been exaggerated. That was the message from Merrill Lynch to its clients yesterday after a meeting with Duncan Tatton-Brown, the retailer's finance director.

Fund managers turn more bullish on shares

Club of Tigers gets ready to roar
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Isis hostage crisis: Militant group stands strong as its numerous enemies fail to find a common plan to defeat it

Isis stands strong as its numerous enemies fail to find a common plan to defeat it

The jihadis are being squeezed militarily and economically, but there is no sign of an implosion, says Patrick Cockburn
Virtual reality thrusts viewers into the frontline of global events - and puts film-goers at the heart of the action

Virtual reality: Seeing is believing

Virtual reality thrusts viewers into the frontline of global events - and puts film-goers at the heart of the action
Homeless Veterans appeal: MP says Coalition ‘not doing enough’

Homeless Veterans appeal

MP says Coalition ‘not doing enough’ to help
Larry David, Steve Coogan and other comedians share stories of depression in new documentary

Comedians share stories of depression

The director of the new documentary, Kevin Pollak, tells Jessica Barrett how he got them to talk
Has The Archers lost the plot with it's spicy storylines?

Has The Archers lost the plot?

A growing number of listeners are voicing their discontent over the rural soap's spicy storylines; so loudly that even the BBC's director-general seems worried, says Simon Kelner
English Heritage adds 14 post-war office buildings to its protected lists

14 office buildings added to protected lists

Christopher Beanland explores the underrated appeal of these palaces of pen-pushing
Human skull discovery in Israel proves humans lived side-by-side with Neanderthals

Human skull discovery in Israel proves humans lived side-by-side with Neanderthals

Scientists unearthed the cranial fragments from Manot Cave in West Galilee
World War Z author Max Brooks honours WW1's Harlem Hellfighters in new graphic novel

Max Brooks honours Harlem Hellfighters

The author talks about race, legacy and his Will Smith film option to Tim Walker
Why the league system no longer measures up

League system no longer measures up

Jon Coles, former head of standards at the Department of Education, used to be in charge of school performance rankings. He explains how he would reform the system
Valentine's Day cards: 5 best online card shops

Don't leave it to the petrol station: The best online card shops for Valentine's Day

Can't find a card you like on the high street? Try one of these sites for individual, personalised options, whatever your taste
Diego Costa: Devil in blue who upsets defences is a reminder of what Liverpool have lost

Devil in blue Costa is a reminder of what Liverpool have lost

The Reds are desperately missing Luis Suarez, says Ian Herbert
Ashley Giles: 'I'll watch England – but not as a fan'

Ashley Giles: 'I'll watch England – but not as a fan'

Former one-day coach says he will ‘observe’ their World Cup games – but ‘won’t be jumping up and down’
Greece elections: In times like these, the EU has far more dangerous adversaries than Syriza

Greece elections

In times like these, the EU has far more dangerous adversaries than Syriza, says Patrick Cockburn
Holocaust Memorial Day: Nazi victims remembered as spectre of prejudice reappears

Holocaust Memorial Day

Nazi victims remembered as spectre of prejudice reappears over Europe
Fortitude and the Arctic attraction: Our fascination with the last great wilderness

Magnetic north

The Arctic has always exerted a pull, from Greek myth to new thriller Fortitude. Gerard Gilbert considers what's behind our fascination with the last great wilderness