Autism begins 'long before birth', claim scientists

The study further de-bunks the discredited theory that vaccines can cause autism

Autism may develop in the womb during pregnancy, researchers claim.

In a study that examined brain tissue samples donated by children who had died, scientists discovered clusters of disorganised cells in regions important for regulating social functioning, emotions and communication - activities that can be difficult for children with autism.

The abnormalities were found in 10 of 11 children with autism, but in only one of 11 children without the disease.

Using sophisticated testing techniques, the authors of the study published in the New England Journal of Medicine detected defects that they claim form during the second or third trimesterns of pregnancy.

The authors said the clusters were probably defects that occurred during the second or third trimesters of pregnancy.

While the cause of the clusters had not yet been determined, lead author Professor Eric Courchesne and autism researcher at the University of California, San Diego explained that the findings “call sharply into questions other popular notions about autism.”

This includes the scientifically debunked theory that childhood vaccines could cause autism.

“It could be [caused by] gene mutations and environmental factors together,” said Professor Courchesne.

However, experts not involved in the study called the results preliminary and said larger studies were needed to determine if the unusual brain development found in the study caused problems and if it was truly common in autism, or even in people without the disorder. 

Scientists have been working for decades to find the cause of autism and increasingly believe its origins begin before birth.

The study follows Courchesne-led research that suggest abnormal gene activity leads to an excessive number of brain cells in the brain's pre-frontal cortex, located behind the forehead.

The same region and adjacent areas of the brain were implicated in the new study.

"These abnormalities are not trivial," Prof Courchesne said. "These are fundamental to developing a human brain."

The new study also involved children aged 2 to 15, while most previous autism brain studies involved samples taken from autopsies of adults.

Dr Thomas Insel, director of the National Institute of Mental Health, said the authors used advanced methods to examine cellular and molecular markers in more detail than previous research. But he said the study "highlights the critical need" for autopsy brain tissue to gain a better understanding of autism.

Additional reporting by PA

Read more: Stressed women ‘30% less likely to become pregnant’
Children of older dads face more health problems
Children with autism are illegally excluded from school activities study finds
News
Sir David Attenborough
people
Life and Style
Young girl and bowl of cereal
food + drink
News
Comic miserablist Larry David in 'Curb Your Enthusiasm'
peopleDirector of new documentary Misery Loves Comedy reveals how he got them to open up
Arts and Entertainment
Henry VIII played by Damien Lewis
tvReview: Scheming queens-in-waiting, tangled lines of succession and men of lowly birth rising to power – sound familiar?
PROMOTED VIDEO
Life and Style
ebookNow available in paperback
ebooks
ebookPart of The Independent’s new eBook series The Great Composers
Sport
football
Arts and Entertainment
'The Archers' has an audience of about five million
radioA growing number of listeners are voicing their discontent; so loudly that even the BBC's director-general seems worried
News
i100
Arts and Entertainment
Ready to open the Baftas, rockers Kasabian are also ‘great film fans’
musicExclusive: Rockers promise an explosive opening to the evening
Life and Style
David Bowie by Duffy
fashion
Arts and Entertainment
Hell, yeah: members of the 369th Infantry arrive back in New York
booksWorld War Z author Max Brooks honours WW1's Harlem Hellfighters in new graphic novel
News
advertisingVideo: The company that brought you the 'Bud' 'Weis' 'Er' frogs and 'Wasssssup' ads, has something up its sleeve for Sunday's big match
Arts and Entertainment
tv
News
i100
Environment
Dame Vivienne Westwood speaking at a fracking protest outside Parliament on Monday (AP)
environment
Life and Style
tech
Latest stories from i100
Have you tried new the Independent Digital Edition apps?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Tradewind Recruitment: English Teacher

    Negotiable: Tradewind Recruitment: This post arises as a result of the need to...

    Tradewind Recruitment: Class Teacher Required ASAP In Uminster

    £120 - £150 per annum: Tradewind Recruitment: I am recruiting on instruction o...

    Ashdown Group: Head of Finance - Financial Director - London - £70,000

    £70000 per annum: Ashdown Group: Head of Finance - Financial Controller - Fina...

    Ashdown Group: Marketing Executive - Wimbledon, SW London

    £24000 - £28000 per annum + benefits: Ashdown Group: Marketing Executive - Wim...

    Day In a Page

    Isis hostage crisis: Militant group stands strong as its numerous enemies fail to find a common plan to defeat it

    Isis stands strong as its numerous enemies fail to find a common plan to defeat it

    The jihadis are being squeezed militarily and economically, but there is no sign of an implosion, says Patrick Cockburn
    Virtual reality thrusts viewers into the frontline of global events - and puts film-goers at the heart of the action

    Virtual reality: Seeing is believing

    Virtual reality thrusts viewers into the frontline of global events - and puts film-goers at the heart of the action
    Homeless Veterans appeal: MP says Coalition ‘not doing enough’

    Homeless Veterans appeal

    MP says Coalition ‘not doing enough’ to help
    Larry David, Steve Coogan and other comedians share stories of depression in new documentary

    Comedians share stories of depression

    The director of the new documentary, Kevin Pollak, tells Jessica Barrett how he got them to talk
    Has The Archers lost the plot with it's spicy storylines?

    Has The Archers lost the plot?

    A growing number of listeners are voicing their discontent over the rural soap's spicy storylines; so loudly that even the BBC's director-general seems worried, says Simon Kelner
    Human skull discovery in Israel proves humans lived side-by-side with Neanderthals

    Human skull discovery in Israel proves humans lived side-by-side with Neanderthals

    Scientists unearthed the cranial fragments from Manot Cave in West Galilee
    World War Z author Max Brooks honours WW1's Harlem Hellfighters in new graphic novel

    Max Brooks honours Harlem Hellfighters

    The author talks about race, legacy and his Will Smith film option to Tim Walker
    Why the league system no longer measures up

    League system no longer measures up

    Jon Coles, former head of standards at the Department of Education, used to be in charge of school performance rankings. He explains how he would reform the system
    Valentine's Day cards: 5 best online card shops

    Don't leave it to the petrol station: The best online card shops for Valentine's Day

    Can't find a card you like on the high street? Try one of these sites for individual, personalised options, whatever your taste
    Greece elections: In times like these, the EU has far more dangerous adversaries than Syriza

    Greece elections

    In times like these, the EU has far more dangerous adversaries than Syriza, says Patrick Cockburn
    Holocaust Memorial Day: Nazi victims remembered as spectre of prejudice reappears

    Holocaust Memorial Day

    Nazi victims remembered as spectre of prejudice reappears over Europe
    Fortitude and the Arctic attraction: Our fascination with the last great wilderness

    Magnetic north

    The Arctic has always exerted a pull, from Greek myth to new thriller Fortitude. Gerard Gilbert considers what's behind our fascination with the last great wilderness
    Homeless Veterans appeal: Homeless in Wales can find inspiration from Daniel’s story

    Homeless Veterans appeal

    Homeless in Wales can find inspiration from Daniel’s story
    Front National family feud? Marine Le Pen and her relatives clash over French far-right party's response to Paris terror attacks

    Front National family feud?

    Marine Le Pen and her relatives clash over French far-right party's response to Paris terror attacks
    Pot of gold: tasting the world’s most expensive tea

    Pot of gold

    Tasting the world’s most expensive tea