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Jose Mourinho's side beat Anderlecht 2-1 in Thursday's second leg at Old Trafford, clinching a 3-2 aggregate victory and book their spot in the last four..
Lyon, Ajax and Celta Vigo join them in the semi-finals, having beated their respective opponents - Besiktas, Genk and Schalke 04 - retain hopes of reaching the final next month.
With a place in next season's Champions League the reward for winning the Europa League, United are determined to win Europe's second-tier competition given they are currently in a fight with Manchester City, Liverpool and Arsenal to finish in the top four.
Follow the draw live below:
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When is the draw?
The draw takes place in Nyon on Friday 21 April, following the completion of the quarter final ties on Thursday.
What time is the draw?
Proceedings will begin at 12.00pm BST, with the draw following shortly after.
Manchester United vs Anderlecht player ratings
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Where can I watch it?
It will be shown live on BT Sport 2.
If, however, you cannot watch the draw, you can bookmark this article which will turn into The Independent’s live blog.
How does it work?
As per usual at this stage of the competition, the draw is unseeded and there will be no ‘country protection’, meaning teams from the same domestic league can be drawn against each other.
The team drawn first will play the first leg at home, with those drawn second away.
Who's in the draw?
Manchester United, Lyon, Celta Vigo and Ajax go into the draw and can all face each other.
When will the Europa League semi-finals take place?
This year’s semi-final first legs will be played on 4 May, with the return legs played the following week on 11 May.
A tough draw for United against the dark horses of the tournament. They'll need to seriously up their game from Thursday night's display if they're to stand any chance of reaching the final.
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