After returning from a trip to play CSKA Moscow with a win, can Mauricio Pochettino's men pick up another three points against team who have a similar high-intensity style?
Leicester City, meanwhile, will hope to maintain their dream start to life at European football's top table.
The Foxes face Copenhagen, the Danish champions, at the King Power Stadium, having won both their opening group games.
Tuesday's Champions League fixtures
All kick-off times are 7.45pm
- Bayer Leverkusen vs Tottenham Hotspur
- CSKA Moscow vs Monaco
- Real Madrid vs Legia Warsaw
- Sporting Lisbon vs Borussia Dortmund
- Club Brugge vs Porto
- Leicester City vs Copenhagen
- Dinamo Zagreb vs Sevilla
- Lyon vs Juventus
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