British Airways will open a daily, non-stop route from London's Heathrow Airport to Las Vegas beginning October 25.
Prices will begin at around £550 (€601) for a round trip, depending on day of travel.
Despite its popularity with British gamblers, Las Vegas has very few direct flights from the UK even though the UK is the number-one international market overseas for visitors to Las Vegas, according to UK website Weak Holidays. British travellers looking to go to "Sin City" usually have to transfer in Frankfurt, it added.
Virgin Atlantic currently offers daily non-stop flights between London's smaller Gatwick International and Las Vegas, beginning at around £510 (€560).