Life and Style

Sleep researchers found that disruption to natural body clock has ‘severe’ impact on finely-tuned DNA

Cycling: Hayles' failed blood test casts shadow over Wiggins win

The first evening session of the world track championships was always likely to end in a celebration of British excellence, but the enforced withdrawal of Rob Hayles after an "anomaly" in a blood test cast a shadow over the performances of Bradley Wiggins and the home sprint team in Manchester last night.

Disappearing tortoises: Playing God in the Galapagos

On one of Darwin's pristine islands, the tortoises are dying out. So should we introduce a similar breed, or simply stop meddling?

Scientists identify genetic cause of prostate cancer

Scientists have made a major advance in understanding the genetic causes of prostate cancer, opening a new front in the battle against the most common malignant disease in men.

Ankylosing Spondylitis: Could my starch intolerance be linked to AS?

"I recently discovered the existence of ankylosing spondylitis (AS) while doing a web search on starch intolerance. Every time I eat starchy food the pain in my lower back, which I have had for more than 20 years, flares up. At the same time I suffer chronic cramping in my intestines. The more I read about AS, the more I am convinced it is the cause of my problems. I've been told the next stage is to see my GP to have a blood test for HLA-B27. Over the years I have often gone to my GP for bowel and back problems and I have been made to feel like a hypochondriac. Twenty years ago I was diagnosed with inflammation of the sacroiliac joint. I don't know what my GP will say if I ask for a blood test, but I imagine it will be dismissive. I've looked into a private test, but it will cost £200 and I can't afford it. What should I do?"

England and Ashton wait on doctor's orders

Brian Ashton never planned to do much in the way of training yesterday ahead of England's opening Six Nations Championship fixture with Wales this weekend, which was probably as well. Seven members of the recently expanded 33-man squad were nursing injuries – some of them of serious concern, others merely irritating – and last night the head coach and his back-room colleagues were awaiting a detailed briefing from the resident medic, Dr Simon Kemp, before settling on their line-up.

Brown pledges more preventative NHS

Gordon Brown promised a more personal and preventative NHS today as a new national health screening programme to provide patients with early warning of some of the biggest killer diseases was announced.

Convulsion terror: Will it happen whenever she has a temperature?

Our 15-month-old daughter has just spent two nights in a children's ward after she had a convulsion, which started when she had a cold and sore throat. She had a high temperature and then started shaking and her breathing because noisy. She was unconscious, or nearly unconscious, for a couple of minutes, before the shaking stopped and she gradually came round. We called an ambulance which arrived quickly, but by then the convulsion had stopped. She was given a blood test, but nothing was found and it was put down to a high fever it was a febrile convulsion. The whole experience was very frightening, but she does not seem to have come to any harm. However, we are now terrified that the same thing will happen the next time she develops a temperature.

Prostate infections: What's the cause?

I have had bouts of pain at the base of my penis for several months, and recently my semen was slightly brown in colour. Ibuprofen takes the pain away, but it comes back in a day or two. After urine tests and a rectal examination, I have been diagnosed with an infection of the prostate gland. The PSA blood test is slightly raised, but I was told this is due to infection, not cancer. What causes prostate infections? I have been put on antibiotics for eight weeks, which seems a long course. I am 38 years old and healthy, and I cycle at least 30 miles a week.

Tiredness: What's the cause?

I have been to two different doctors in the past month complaining of feeling generally run-down. The second doctor listened to my heart and lungs, felt my belly, tested my urine but couldn't find anything wrong. Now I've begun to sweat heavily in bed. I work long days behind a desk, but in the evening I just want to lie down and sleep. Until a few months ago I was full of energy and up for anything. I am 35 years old, a non-smoker, and consider myself to be perfectly healthy.

Beta Thalassaemia: a genetic legacy

"I've been having tests for anaemia, and the laboratory has discovered that I carry beta thalassaemia. I've been told that this won't cause me any problems, but my parents and grandparents were born in the UK and, as far as we know, there is no Mediterranean or Middle Eastern ancestry in our family, so how is it possible that I have this condition, which is supposed to affect only people from other parts of the world?"

ITP: what is it?

I developed a pin-prick rash on my arms and legs, which spread quickly over two days. I was also bleeding from my gums, and had blood in my stools. I had a blood test, which showed that my platelet count was low. I have been told that I have ITP. No one knows the cause. I have been given steroids, which has improved the rash, but I'm told that my blood is still abnormal. Will I need to stay on steroids for ever?

Blurred Vision: Could it be linked to my red blood cell count?

I consulted my GP about my vision blurring and general tiredness. An optician's eye examination had shown no eye defect. Blood tests came back normal except for an excess red cell count. This is the second time in two years this has been picked up. Could this cause my symptoms?

Thyroid: Am I taking too much medication?

I have been diagnosed with an underactive thyroid gland, and now have to take thyroxine tablets every day. I was started on a low dose, and this has gradually been increased because blood tests still show my levels to be low. The starting dose was 50mcg a day, and I am now up to 300mcg a day. Is there a maximum dose that is safe? And could I take a dose as high as 400mcg a day, if it were necessary?

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Independent Travel
Pompeii, Capri & the Bay of Naples
Seven Cities of Italy
Burgundy, the River Rhone & Provence
Prague, Budapest and Vienna
Lake Garda
3.	Provence 6 nights B&B by train from £599pp
Prices correct as of 12 March 2015
Election 2015: How many of the Government's coalition agreement promises have been kept?

Promises, promises

But how many coalition agreement pledges have been kept?
The Gaza fisherman who built his own reef - and was shot dead there by an Israeli gunboat

The death of a Gaza fisherman

He built his own reef, and was fatally shot there by an Israeli gunboat
Saudi Arabia's airstrikes in Yemen are fuelling the Gulf's fire

Saudi airstrikes are fuelling the Gulf's fire

Arab intervention in Yemen risks entrenching Sunni-Shia divide and handing a victory to Isis, says Patrick Cockburn
Zayn Malik's departure from One Direction shows the perils of fame in the age of social media

The only direction Zayn could go

We wince at the anguish of One Direction's fans, but Malik's departure shows the perils of fame in the age of social media
Young Magician of the Year 2015: Meet the schoolgirl from Newcastle who has her heart set on being the competition's first female winner

Spells like teen spirit

A 16-year-old from Newcastle has set her heart on being the first female to win Young Magician of the Year. Jonathan Owen meets her
Jonathan Anderson: If fashion is a cycle, this young man knows just how to ride it

If fashion is a cycle, this young man knows just how to ride it

British designer Jonathan Anderson is putting his stamp on venerable house Loewe
Number plates scheme could provide a licence to offend in the land of the free

Licence to offend in the land of the free

Cash-strapped states have hit on a way of making money out of drivers that may be in collision with the First Amendment, says Rupert Cornwell
From farm to fork: Meet the Cornish fishermen, vegetable-growers and butchers causing a stir in London's top restaurants

From farm to fork in Cornwall

One man is bringing together Cornwall's most accomplished growers, fishermen and butchers with London's best chefs to put the finest, freshest produce on the plates of some of the country’s best restaurants
Robert Parker interview: The world's top wine critic on tasting 10,000 bottles a year, absurd drinking notes and New World wannabes

Robert Parker interview

The world's top wine critic on tasting 10,000 bottles a year, absurd drinking notes and New World wannabes
Don't believe the stereotype - or should you?

Don't believe the stereotype - or should you?

We exaggerate regional traits and turn them into jokes - and those on the receiving end are in on it too, says DJ Taylor
How to make your own Easter egg: Willie Harcourt-Cooze shares his chocolate recipes

How to make your own Easter egg

Willie Harcourt-Cooze talks about his love affair with 'cacao' - and creates an Easter egg especially for The Independent on Sunday
Bill Granger recipes: Our chef declares barbecue season open with his twist on a tradtional Easter Sunday lamb lunch

Bill Granger's twist on Easter Sunday lunch

Next weekend, our chef plans to return to his Aussie roots by firing up the barbecue
Joe Marler: 'It's the way I think the game should be played'

Joe Marler: 'It's the way I think the game should be played'

The England prop relives the highs and lows of last Saturday's remarkable afternoon of Six Nations rugby
Cricket World Cup 2015: Has the success of the tournament spelt the end for Test matches?

Cricket World Cup 2015

Has the success of the tournament spelt the end for Test matches?
The Last Word: Justin Gatlin knows the price of everything, the value of nothing

Michael Calvin's Last Word

Justin Gatlin knows the price of everything, the value of nothing