Life and Style Last.fm users can now stream music from Spotify's catalogue

Last.fm users will now have access to the 20 million songs available on Spotify

Modern approaches to cancer therapy are based on diagnosing the disease at the level of the DNA. Drugs, such as Herceptin, can then be targeted at those patients with a particular genetic profile. This can produce better results as well as eliminating unnecessary therapy in patients who would otherwise not respond to treatment

Forensic cancer treatment: Personalised drugs therapy becoming a reality with hopes for improvement in survival rates

A decade ago it took tens of millions of pounds and many years to sequence the compete genome of one individual. Now it takes a few hundred pounds and a couple of days to decode the entire DNA of a cancer cell.

Childminders and nurseries can now look after more children - this means the quality of care will diminish

It doesn’t take a child care expert to know this will have a devastating impact - poorer parents will also be forced to pay for lower quality care

Ni no Kuni: Wrath of the White Witch – Review

Studio Ghibli and Level-5 combine to create a beautiful gaming experience designed for you to spend hours exploring.

20 ways to be really annoying in the library

The library is a vital place for students. It is the sanctuary where our most innovative thinking is produced and our most significant work completed, and it is a haven from the distractions of the outside world. Well that may all be exaggerating slightly, but it is a place you go to when an important deadline is looming and you really need to concentrate.

The Surface: Microsoft is hoping to own the ‘tablets for typists’ market

The 10 Best fitness gadgets

You know the drill: new year means new plans to get fit. Make life easy with these clever and funky bits of kit...

Editorial: The Prince and the commoner's Christmas

What, one wonders, did Prince William make of Christmas chez the Middletons? A bit on the cramped side, accommodation-wise, perhaps, compared with Sandringham, but less draughty, too. Do they have a real tree or an artificial one? Lights flashing or not? And without staff – we may be wrong, but we assume the Middletons do their own cooking and serving – there may have been a bit more, how shall we put it, jostling and banter at table, if only to get another helping of cranberry sauce.

Grace Dent on TV: Inside Claridge's, BBC2

I love Claridge's, but I do wish these cosseted toffs didn't have it quite so easy

‘Club to Catwalk: London Fashion in the 1980s’ opens at the V&A on 10 July 2013, vam.ac.uk

Goths and fetishwear: V&A celebrates club scene of 1980s

The hedonistic partying ways of young starlets like Rihanna have nothing on the club kids of the Eighties – as the Victoria & Albert Museum's summer exhibition will attest.

Private quarters: Four luxury family and VIP suites and a prayer room that generates virtual prayer mats facing Mecca

Doors to manual, taps off in the Turkish spa... the Saudi prince whose flying palace has it all

Saudi investor’s £300m super-jumbo also has room for a concert hall, a garage for his Rolls and four luxury suites

Sussex-based Nessie Maclay designs beautiful handmade greeting cards and stationery for her company Thisisnessie
Sussex-based Nessie Maclay designs beautiful handmade greeting cards and stationery for her company Thisisnessie
Santi Cazorla is accused of diving

PFA chief: Technology can be used to tackle diving

Santi Cazorla won a penalty with a blatant dive at the weekend

£100m DNA mapping project for cancer patients announced

Cameron said he wanted to "push the boundaries" by introducing genetic sequencing to a mainstream health service for the first time

Arts and Entertainment
Sir Bruce Forsyth with Tess Daly in the BBC's Strictly Come Dancing Christmas Special
tvLouis Smith wins with 'Jingle Bells' quickstep on Strictly Come Dancing's Christmas Special
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peopleIt seems you can't silence Katie Hopkins, even on Christmas Day...
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Wolf (Nathan McMullen), Ian (Dan Starky), The Doctor (Peter Capaldi), Clara (Jenna Coleman), Santa Claus (Nick Frost) in the Doctor Who Christmas Special (BBC/Photographer: David Venni)
tvOur review of the Doctor Who Christmas Special
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Left to right: Stanley Tucci, Sophie Grabol and Christopher Eccleston in ‘Fortitude’
tvSo Sky Atlantic arrived in Iceland to film their new and supposedly snow-bound series 'Fortitude'...
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Jenna Coleman as Clara Oswald in the Doctor Who Christmas special
tvForget the rumours that Clara Oswald would be quitting the Tardis
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Japanese artist Megumi Igarashi showing a small mascot shaped like a vagina
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The Queen delivers her Christmas message
newsTwitter reacts to Her Majesty's Christmas Message
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Burgundy, the River Rhone & Provence – Five-star MS Swiss Corona 7 nights from £999pp
Lake Como St Moritz & the Bernina Express 7 nights from £809pp
Vietnam
Lake Maggiore, Orta & the Matterhorn 7 nights from £939pp
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Prices correct as of 19 December 2014
Isis in Iraq: Yazidi girls killing themselves to escape rape and imprisonment by militants

'Jilan killed herself in the bathroom. She cut her wrists and hanged herself'

Yazidi girls killing themselves to escape rape and imprisonment
Ed Balls interview: 'If I think about the deficit when I'm playing the piano, it all goes wrong'

Ed Balls interview

'If I think about the deficit when I'm playing the piano, it all goes wrong'
He's behind you, dude!

US stars in UK panto

From David Hasselhoff to Jerry Hall
Grace Dent's Christmas Quiz: What are you – a festive curmudgeon or top of the tree?

Grace Dent's Christmas Quiz

What are you – a festive curmudgeon or top of the tree?
Nasa planning to build cloud cities in airships above Venus

Nasa planning to build cloud cities in airships above Venus

Planet’s surface is inhospitable to humans but 30 miles above it is almost perfect
Surrounded by high-rise flats is a little house filled with Lebanon’s history - clocks, rifles, frogmen’s uniforms and colonial helmets

Clocks, rifles, swords, frogmen’s uniforms

Surrounded by high-rise flats is a little house filled with Lebanon’s history
Return to Gaza: Four months on, the wounds left by Israel's bombardment have not yet healed

Four months after the bombardment, Gaza’s wounds are yet to heal

Kim Sengupta is reunited with a man whose plight mirrors the suffering of the Palestinian people
Gastric surgery: Is it really the answer to the UK's obesity epidemic?

Is gastric surgery really the answer to the UK's obesity epidemic?

Critics argue that it’s crazy to operate on healthy people just to stop them eating
Homeless Veterans appeal: Christmas charity auction Part 2 - now LIVE

Homeless Veterans appeal: Christmas charity auction

Bid on original art, or trips of a lifetime to Africa or the 'Corrie' set, and help Homeless Veterans
Pantomime rings the changes to welcome autistic theatre-goers

Autism-friendly theatre

Pantomime leads the pack in quest to welcome all
The week Hollywood got scared and had to grow up a bit

The week Hollywood got scared and had to grow up a bit

Sony suffered a chorus of disapproval after it withdrew 'The Interview', but it's not too late for it to take a stand, says Joan Smith
From Widow Twankey to Mother Goose, how do the men who play panto dames get themselves ready for the performance of a lifetime?

Panto dames: before and after

From Widow Twankey to Mother Goose, how do the men who play panto dames get themselves ready for the performance of a lifetime?
Thirties murder mystery novel is surprise runaway Christmas hit

Thirties murder mystery novel is surprise runaway Christmas hit

Booksellers say readers are turning away from dark modern thrillers and back to the golden age of crime writing
Anne-Marie Huby: 'Charities deserve the best,' says founder of JustGiving

Anne-Marie Huby: 'Charities deserve the best'

Ten million of us have used the JustGiving website to donate to good causes. Its co-founder says that being dynamic is as important as being kind
The botanist who hunts for giant trees at Kew Gardens

The man who hunts giants

A Kew Gardens botanist has found 25 new large tree species - and he's sure there are more out there