Russell Wilson will attempt to guide the Seattle Seahawks to Super Bowl success

NFL: Seattle Seahawks to face Denver Broncos in Super Bowl

Seattle holds on to beat the San Francisco 49ers while the Broncos beat the New England Patriots to set up Super Bowl XLVIII

Tom Brady will go up against arch-rival Peyton Manning on Saturday

American Football: Cream rises to top as final battle for Super Bowl begins

It's Conference Championship weekend, and the four best teams in the NFL lock horns for a shot at the sport's ultimate prize

Sam Berns with his parents in March 2009, when he was 12 years old

Sam Berns: Teenager whose struggle with disease became the subject of an acclaimed HBO documentary

Sam Berns, who has died at the age of 17, was a teenager whose struggle with a rare genetic condition that accelerates the aging process became the subject of a television documentary. He died from complications of Hutchinson-Gilford progeria syndrome, commonly known as progeria. The Progeria Research Foundation was founded by his parents.

Anquan Boldin, right, and Quintin Mikel collide in last night’s NFC Divisional play-off

American Football: Colin Kaepernick guides wild cards San Francisco to a showdown in Seattle with top-seeded Seahawks

Niners quarterback completed 15 of 28 passes for 196 yards

Seattle, led by Russell Wilson, are favourites to win next month's Super Bowl

American Football: All eyes on rising star Russell Wilson as Seattle aim to end 35 years of hurt

For devotees of the NFL, this is as good as it gets – the divisional round of the play-offs, four games pitting the regular season’s finest against four challengers already battle-hardened by victory in last weekend’s ever-treacherous wild-card round. And in 2014 there’s an extra twist: the prospect that one of the longest, most painful droughts in US sport might be near an end.

New England Patriots quarterback Tom Brady

NFL Divisional Playoff: Indianapolis Colts v New England Patriots match preview

A look ahead to this weekend’s Divisional Playoff match at Gillette Stadium in New England

Mind games: San Diego’s quarterback Philip Rivers (centre) says his team have the right mentality to succeed

American Football: San Diego Chargers gather pace at right time for title tilt

Momentum, if not logic, favour Mike McCoy's men in Super Bowl race

Peyton Manning broke Tom Brady's record for touchdown passes in a season

NFL: Indianapolis Colts must beware a (Peyton) Manning scorned

Devastated by injury and dumped by his beloved team, one of the NFL’s all-time great quarterbacks is back in business and breaking records

Pittsburgh Steelers head coach Mike Tomlin was left to reflect on what could have been after his side missed out on the play-offs

NFL: It could have been so different for Pittsburgh had luck not played such a huge part

A round-up of the final week's NFL regular season action as the play-off berth's get locked down

Quarterback Peyton Manning #18 of the Denver Broncos and quarterback Tom Brady #12 of the New England Patriots

NFL: Tom Brady v Peyton Manning is a rivalry for the ages, and Sunday proved it

A round-up of the latest events and talking points from the world of NFL

Tom Brady of the Patriots was furious after the defeat to the Panthers

NFL round-up: Regardless of the non-call, the Carolina Panthers deserved to beat the New England Patriots

A debatable non-call on Monday night will steal the headlines, but week 11 saw the gap between the haves and have-nots increase further

Head coach Joe Philbin of the Miami Dolphins
Richie Incognito has given an interview to Fox Sports

NFL: Suspended Richie Incognito explains he is ‘not a racist’ whilst fellow Miami Dolphin team-mates defend him

Offensive Linesman has given first interview since being suspended

LeGarrette Blount #29 of the New England Patriots reacts after he scored a touchdown in the second half against the Pittsburgh Steelers

NFL round-up: Hazing and health concerns aside, week nine was a watershed moment for Pittsburgh Steelers

A look at the major talking points from week nine in the NFL

Peyton Manning

NFL: Winless and undefeated - the Manning's are worlds apart

A weekly look at the biggest talking points in the NFL

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General Election 2015: Ed Miliband's unlikely journey from hapless geek to heart-throb

Miliband's unlikely journey from hapless geek to heart-throb

He was meant to be Labour's biggest handicap - but has become almost an asset
General Election 2015: A guide to the smaller parties, from the the National Health Action Party to the Church of the Militant Elvis Party

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From Militant Elvis to Women's Equality: a guide to the underdogs standing in the election
Amr Darrag: Ex-Muslim Brotherhood minister in exile still believes Egypt's military regime can be replaced with 'moderate' Islamic rule

'This is the battle of young Egypt for the future of our country'

Ex-Muslim Brotherhood minister Amr Darrag still believes the opposition can rid Egypt of its military regime and replace it with 'moderate' Islamic rule, he tells Robert Fisk
Why patients must rely less on doctors: Improving our own health is the 'blockbuster drug of the century'

Why patients must rely less on doctors

Improving our own health is the 'blockbuster drug of the century'
Sarah Lucas is the perfect artist to represent Britain at the Venice Biennale

Flesh in Venice

Sarah Lucas has filled the British pavilion at the Venice Biennale with slinky cats and casts of her female friends' private parts. It makes you proud to be a woman, says Karen Wright
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11 best anti-ageing day creams

Slow down the ageing process with one of these high-performance, hardworking anti-agers
Juventus 2 Real Madrid 1: Five things we learnt, including Iker Casillas is past it and Carlos Tevez remains effective

Juventus vs Real Madrid

Five things we learnt from the Italian's Champions League first leg win over the Spanish giants
Ashes 2015: Test series looks a lost cause for England... whoever takes over as ECB director of cricket

Ashes series looks a lost cause for England...

Whoever takes over as ECB director of cricket, says Stephen Brenkley
Fishing for votes with Nigel Farage: The Ukip leader shows how he can work an audience as he casts his line to the disaffected of Grimsby

Fishing is on Nigel Farage's mind

Ukip leader casts a line to the disaffected
Who is bombing whom in the Middle East? It's amazing they don't all hit each other

Who is bombing whom in the Middle East?

Robert Fisk untangles the countries and factions
China's influence on fashion: At the top of the game both creatively and commercially

China's influence on fashion

At the top of the game both creatively and commercially
Lord O’Donnell: Former cabinet secretary on the election and life away from the levers of power

The man known as GOD has a reputation for getting the job done

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Rainbow shades

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'It was first time I had ever tasted chocolate. I kept a piece, and when Amsterdam was liberated, I gave it to the first Allied soldier I saw'

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