Breakthrough could lead to cure for chronic liver disease

Medical scientists have taken an important step towards understanding how the diseased liver can repair itself in a breakthrough that could eventually lead to the development of new treatments for chronic liver illnesses, which at present can only be cured by organ transplants.

Winning ways: the chef Wolfgang Puck shows the foods on offer at the Oscars

Served with ceremony: The culinary trends at this year's awards parties

Tim Walker gets to sample delicacies including edible gold flakes and mojito mousse

Doctors warn on alcohol deaths

More than 200,000 people could die early from alcohol over the next 20 years, leading doctors have warned.

James Moore: Bolland's bacon saved as M&S counts the cost of Christmas flop

If Marks & Spencer's Christmas figures are anything to go by, the pixie dust Marc Bolland sprinkled on Morrisons to make it fly has been in short supply. Yesterday's trading statement was no Christmas cracker and the shares would have taken a beating had it not been for a bravura performance by the retailer's food halls. That saved Mr Bolland's bacon, at least for now.

James Moore: Food saves Bolland's bacon as M&S counts the cost of a Christmas flop

Outlook If Marks & Spencer's Christmas figures are anything to go by, the pixie dust Marc Bolland sprinkled on Morrisons to make it fly has been in short supply. Yesterday's trading statement was no Christmas cracker and the shares would have taken a beating had it not been for a bravura performance from the retailer's food offering. That saved Mr Bolland's bacon. At least for now.

The Government is under growing pressure to rethink its imminent alcohol strategy and its guidelines for sensible drinking

Alcohol: keep a clear head

A new government report on drinking alcohol aims to give us easy to understand, no-nonsense advice. But are we ready to listen?

The Commons' Science and Technology Committee believed abstaining from alcohol at least twice a week would help people's health

Drinkers should have two alcohol-free days a week

Drinkers should give themselves two alcohol-free days a week, a committee of MPs said today.

Roberto Bolaño: 'The Spanish language is my homeland'

The Third Reich, By Roberto Bolaño (trs Natasha Wimmer)

A newly translated novel, written in the 1980s, reveals the preoccupations of a Chilean master as well has his trademark sarcasm and dark humour

January liver detoxes are 'futile' say hepatologist

Going on a New Year detox to cleanse your liver is "medically futile", health experts warned yesterday.

Joe Tizzard clears the water jump on Cue Card at Newbury

Cut in distance leaves Cue Card holding all the aces

The last day of an old year is as good a time as any to look to the future. Racing is unusual among sports that callow young beginners regularly compete on the same programmes as seasoned veterans, rather than being tucked away at junior meets or youth squad matches. And their presence in the public eye from the start makes the tracing of real talent all the more absorbing, though it's spotting not necessarily easier.

Twins born with one body and two heads

Hospital officials in northern Brazil say a woman have given birth to conjoined twin boys with one body and two heads.

Alcohol diseases double in 7 years

The Health Minister Andrew Lansley was forced to defend his controversial "hands off" approach to public health yesterday as new figures revealed hospital admissions for alcohol-related diseases have doubled in the past seven years.

Right-to-die suicide letter angry at MP's 'cowardice'

A British woman who travelled to Switzerland to die has condemned the "cowardice of politicians" which forced her to spend her last hours away from home.

Pledge over drink advertising aimed at young

Ministers charged with delivering the Olympic Games have vowed to protect young people from binge drinking.

Ali and Frazier fought some of the greatest heavy-weight bouts of all time

Muhammad Ali praying for Joe Frazier

Former world heavyweight champion Muhammad Ali today said he was praying for Joe Frazier following the news of his great rival's battle against cancer.

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Fans line up at the AVNs, straining to capture a photo of their favourite star
life Tim Walker asks how much longer it can flesh out an existence
Life and Style
Every minute of every day, Twitter is awash with anger as we seek to let these organisations know precisely what we think of them
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Norway’s ‘The Nordland Line – Minute by Minute, Season by Season’ continues the trend of slow TV
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Jonny Evans has pleaded not guilty to an FA charge for spitting at Papiss Cisse
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Kate Moss will make a cameo appearance in David Walliams' The Boy in the Dress
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The image released by the Salvation Army, using 'The Dress'
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Liverpool defender Kolo Toure
football Defender could make history in the FA Cup, but African Cup of Nations win means he's already content
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Independent Travel
Pompeii, Capri & the Bay of Naples
Seven Cities of Italy
Burgundy, the River Rhone & Provence
Prague, Budapest and Vienna
Lake Garda
3.	Provence 6 nights B&B by train from £599pp
Prices correct as of 20 February 2015
Homeless Veterans campaign: Donations hit record-breaking £1m target after £300,000 gift from Lloyds Bank

Homeless Veterans campaign

Donations hit record-breaking £1m target after huge gift from Lloyds Bank
Flight MH370 a year on: Lost without a trace – but the search goes on

Lost without a trace

But, a year on, the search continues for Flight MH370
Germany's spymasters left red-faced after thieves break into brand new secret service HQ and steal taps

Germany's spy HQ springs a leak

Thieves break into new €1.5bn complex... to steal taps
International Women's Day 2015: Celebrating the whirlwind wit of Simone de Beauvoir

Whirlwind wit of Simone de Beauvoir

Simone de Beauvoir's seminal feminist polemic, 'The Second Sex', has been published in short-form for International Women's Day
Mark Zuckerberg’s hiring policy might suit him – but it wouldn’t work for me

Mark Zuckerberg’s hiring policy might suit him – but it wouldn’t work for me

Why would I want to employ someone I’d be happy to have as my boss, asks Simon Kelner
Confessions of a planespotter: With three Britons under arrest in the UAE, the perils have never been more apparent

Confessions of a planespotter

With three Britons under arrest in the UAE, the perils have never been more apparent. Sam Masters explains the appeal
Russia's gulag museum 'makes no mention' of Stalin's atrocities

Russia's gulag museum

Ministry of Culture-run site 'makes no mention' of Stalin's atrocities
The big fresh food con: Alarming truth behind the chocolate muffin that won't decay

The big fresh food con

Joanna Blythman reveals the alarming truth behind the chocolate muffin that won't decay
Virginia Ironside was my landlady: What is it like to live with an agony aunt on call 24/7?

Virginia Ironside was my landlady

Tim Willis reveals what it's like to live with an agony aunt on call 24/7
Paris Fashion Week 2015: The wit and wisdom of Manish Arora's exercise in high camp

Paris Fashion Week 2015

The wit and wisdom of Manish Arora's exercise in high camp
8 best workout DVDs

8 best workout DVDs

If your 'New Year new you' regime hasn’t lasted beyond February, why not try working out from home?
Paul Scholes column: I don't believe Jonny Evans was spitting at Papiss Cissé. It was a reflex. But what the Newcastle striker did next was horrible

Paul Scholes column

I don't believe Evans was spitting at Cissé. It was a reflex. But what the Newcastle striker did next was horrible
Miguel Layun interview: From the Azteca to Vicarage Road with a million followers

From the Azteca to Vicarage Road with a million followers

Miguel Layun is a star in Mexico where he was criticised for leaving to join Watford. But he says he sees the bigger picture
Frank Warren column: Amir Khan ready to meet winner of Floyd Mayweather v Manny Pacquiao

Khan ready to meet winner of Mayweather v Pacquiao

The Bolton fighter is unlikely to take on Kell Brook with two superstar opponents on the horizon, says Frank Warren
War with Isis: Iraq's government fights to win back Tikrit from militants - but then what?

Baghdad fights to win back Tikrit from Isis – but then what?

Patrick Cockburn reports from Kirkuk on a conflict which sectarianism has made intractable