Life and Style

The sight of thousands of people with previously incurable forms of blindness could be saved thanks to a pioneering new gene therapy that requires just one operation.

Letters: Time for a change in drugs policy

'The Wire' comes to the English seaside

The Sonnets: 152

By William Shakespeare

Oops, we did it again - Why we make mistakes

Why do we make stupid mistakes? A new book says people have design faults that inevitably lead to slip-ups – but we can train ourselves to avoid them.

Blindness cure to be trialled in UK



A revolutionary new treatment that could cure certain types of blindness is to be trialled in Britain, it was announced.

Matthew Wadsworth/Carolyn Sampson, Wigmore Hall, London

Reviewed by Michael Church

UK at risk of losing lead in stem cell research

Britain's attempts to take stem cell research from the laboratory to the clinic are being undermined by government red tape and a lack of interest from City investors, according to experts meeting in London today.

Blindness (18)

Dystopian Breakdown, Part I. An epidemic of blindness grips a city population, and its first victims are herded into a ramshackle facility under guard.

Britain in push to bring Syria in from the cold

Foreign Secretary David Miliband accepts invitation to visit Damascus after 'important change in approach'

She supported the NHS – then it let her down

A two-year delay in approving a drug has cost one elderly woman her sight

How to cut the cost of glasses, contacts and laser eye surgery

You can improve your sight without breaking the bank – if you know where to look, says Kate Hughes

The Weasel: A spectacle of myself

The striking depiction of the Weasel by Lucinda Rogers that illuminates this column on a weekly basis is, of course, an impeccably accurate likeness of the author. But if compelled to make a criticism of my likeness I might point out that the specs are wrong. I went through my John Lennon phase over two decades ago. Though fine for the sardonic Scouser's beaky nose, they didn't do much for the Weaselian features, even with the oh-so-cool (or so I thought) amendment of a blue tint to the lenses. After that, I had a brief flirtation with contact lenses. This was even less of a success since the soft lenses failed to correct my astigmatism. "Have you ever considered wearing glasses with your contact lenses?" inquired the ophthalmologist. Whenever I've told the story to opticians they find nothing amusing in it at all.

Trail Of The Unexpected: The game is afoot... Sherlock Holmes and the FA Cup connection

As Portsmouth FC take on Cardiff City in this afternoon's FA Cup final, the players from Pompey (as the team is always known) may find themselves watched over by the spirit of an erstwhile goalkeeper and leading light of Victorian England.

The blind man who was given the gift of sight by gene therapy

A pioneering gene therapy trial has helped a blind man to see in a breakthrough that brings hope to millions affected by eye diseases. British scientists have claimed a world first for the revolutionary treatment, which involved a single injection into the retina at the back of the eye.

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Pompeii, Capri & the Bay of Naples
Seven Cities of Italy
Burgundy, the River Rhone & Provence
Prague, Budapest and Vienna
Lake Garda
Minoan Crete and Santorini
Prices correct as of 1 May 2015
Fishing for votes with Nigel Farage: The Ukip leader shows how he can work an audience as he casts his line to the disaffected of Grimsby

Fishing is on Nigel Farage's mind

Ukip leader casts a line to the disaffected
Who is bombing whom in the Middle East? It's amazing they don't all hit each other

Who is bombing whom in the Middle East?

Robert Fisk untangles the countries and factions
China's influence on fashion: At the top of the game both creatively and commercially

China's influence on fashion

At the top of the game both creatively and commercially
Lord O’Donnell: Former cabinet secretary on the election and life away from the levers of power

The man known as GOD has a reputation for getting the job done

Lord O'Donnell's three principles of rule
Rainbow shades: It's all bright on the night

Rainbow shades

It's all bright on the night
'It was first time I had ever tasted chocolate. I kept a piece, and when Amsterdam was liberated, I gave it to the first Allied soldier I saw'

Bread from heaven

Dutch survivors thank RAF for World War II drop that saved millions
Britain will be 'run for the wealthy and powerful' if Tories retain power - Labour

How 'the Axe' helped Labour

UK will be 'run for the wealthy and powerful' if Tories retain power
Rare and exclusive video shows the horrific price paid by activists for challenging the rule of jihadist extremists in Syria

The price to be paid for challenging the rule of extremists

A revolution now 'consuming its own children'
Welcome to the world of Megagames

Welcome to the world of Megagames

300 players take part in Watch the Skies! board game in London
'Nymphomaniac' actress reveals what it was really like to star in one of the most explicit films ever

Charlotte Gainsbourg on 'Nymphomaniac'

Starring in one of the most explicit films ever
Robert Fisk in Abu Dhabi: The Emirates' out-of-sight migrant workers helping to build the dream projects of its rulers

Robert Fisk in Abu Dhabi

The Emirates' out-of-sight migrant workers helping to build the dream projects of its rulers
Vince Cable interview: Charging fees for employment tribunals was 'a very bad move'

Vince Cable exclusive interview

Charging fees for employment tribunals was 'a very bad move'
Iwan Rheon interview: Game of Thrones star returns to his Welsh roots to record debut album

Iwan Rheon is returning to his Welsh roots

Rheon is best known for his role as the Bastard of Bolton. It's gruelling playing a sadistic torturer, he tells Craig McLean, but it hasn't stopped him recording an album of Welsh psychedelia
Morne Hardenberg interview: Cameraman for BBC's upcoming show Shark on filming the ocean's most dangerous predator

It's time for my close-up

Meet the man who films great whites for a living
Increasing numbers of homeless people in America keep their mobile phones on the streets

Homeless people keep mobile phones

A homeless person with a smartphone is a common sight in the US. And that's creating a network where the 'hobo' community can share information - and fight stigma - like never before