A Wrinkle in Time trailer: Behold the power of Oprah in Ava DuVernay's Disney adaptation

With Mindy Kaling and Reese Witherspoon by her side, these are some ladies you seriously don't want to mess with

Oprah Winfrey, Mindy Kaling, and Reese Witherspoon.

That's a trio you don't want to mess with. They star as Mrs. Which, Mrs. Who, and Mrs. Whatsit respectively: three mysterious women who aid a young girl, Meg Murry (Storm Reid), in the search for her missing scientist father.

Disney's new film adapts Madeleine L'Engle's 1936 novel of the same name, with a first trailer lavishly unveiled at this year's D23 convention.

What's most exciting, however, is the talent behind the camera on this one. A Wrinkle in Time marks Ava DuVernay's grand return to feature film after Selma, having since created TV's Queen Sugar and directed and written the Oscar-nominated doc 13th.

The film also stars Gugu Mbatha-Raw as Meg's mother, alongside Zach Galifianakis, Levi Miller, Michael Peña, and André Holland.

A Wrinkle in Time hits UK cinemas 23 March 2018.