The pop star, who is currently working on the music video for her hit single "thank u, next", posted a photo of herself with her ex-boyfriend on Thanksgiving, writing "you're v missed".
While most of the replies were positive and full of support, one troll wrote: "She milkin [sic] this sh*t bruh".
Grande replied: "I pray you never have to deal with anything like this ever and I'm sending you peace and love."
Clearly affected by cruel comments on social media, she then tweeted: "Some of the sh*t I read on here makes me sick to my stomach. It scares me the way some people think and I don't like this world a lot of the time. If only we could be more compassionate and gentle with one another. That'd be sick."
She added: "Everything I feel is valid and safe. Everything I do is genuine and honest. There is no right or wrong during this period."
Grande's friend and fellow artist Halsey then replied to her tweet and said: "The world could only dream of being as compassionate and gentle as you. And since ur being [sic], as always, so classy and nice, allow me the honour of telling them to shut the f*** up."
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