The pop singer saw her fourth full-length studio album sell 231,000 equivalent units, including 127,000 traditional copies, to secure the top spot. Her 2013 album Yours Truly and 2014's My Everything also reached No.1, while her 2016 record Dangerous Woman peaked at No.2.
Sweetener also achieved the second best sales week for a female artist this year, behind Cardi B's hit debut Invasion of Privacy. It bumped Travis Scott's album Astroworld to No.2 after two weeks on top, while Nicki Minaj's new record Queen moved to No.3 with 95,000 total copies sold.
Rounding off the top five this week are Drake with Scorpion and Post Malone with Beerbongs & Bentleys, at No.4 and No.5 respectively.
In the UK, Grande knocked the Mamma Mia! soundtrack off the top spot. She told OfficialCharts.com she was "so grateful" and couldn't wait to see her UK fans in September.
"The emotional highlight is 'Breathin'... a mental health bop over a good, solid pop beat," the review said. "By contrast, Missy Elliott's guest bars are a disaster. She phones in a verse so devoid of personality that it barely sounds like her on a dated, shambles of a song ('Borderline') that should have been cut."
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